生物润滑用聚合物材料研究进展

doi:10.3969/j.issn.2097-2806.2025.01.002

摘要/Abstract

摘要：

生物体不同组织维系正常的生理功能离不开天然润滑剂对组织摩擦界面的润滑作用。当组织界面因各种因素导致润滑功能丧失时，即需要依靠功能性外源润滑材料提供润滑功能。本研究在详细介绍天然润滑剂的种类及生物界面润滑机制的基础上，综述了近年来国内外对于不同组织摩擦界面的润滑策略和聚合物润滑材料构建方面的研究进展。重点总结了用于皮肤保湿润滑、关节软骨润滑、黏膜润滑、抗组织粘连和医用导管润滑等聚合物材料的作用机理、润滑性能和兼具的生物学功能，强调了这些聚合物材料在降低组织摩损和促进受损组织修复方面的独特贡献。此外，还对聚合物润滑材料的功能性优化和应用开发进行了前瞻性展望，希望为聚合物材料在生物组织界面润滑领域的未来发展提供一定的指导作用。

关键词: 生物润滑剂, 润滑机制, 聚合物, 仿生润滑

Abstract:

Natural lubricants play an important role in the functions of living organisms. When the lubrication for tissue interface were lost due to various factors, exogenous lubricant material would be necessary to provide lubrication property. In this review, the types of natural lubricants and the lubrication mechanism at biological interfaces are introduced in detail. The recent research progress on the lubrication strategies for different tissue friction interfaces and on the construction of polymeric lubrication materials are reviewed. Specifically, the conformational relationships, lubrication properties, and additional biological functions of the polymeric materials used for skin moisturizing and lubrication, articular cartilage lubrication, mucosal lubrication, anti-tissue adhesion, as well as medical catheter lubrication are summarized. The unique contributions of these polymeric materials in reducing tissue friction and promoting repair of damaged tissues are emphasized. In addition, the optimization of functionality, and the practical applications of polymeric lubricant materials are prospected, which might provide guidance for the future development of polymeric materials in the field of lubrication at biological tissue interfaces.

Key words: biolubricant, lubrication mechanism, polymer, biomimetic lubrication

中图分类号:

TQ423

侯仕达, 彭平, 刘远康, 颜静, 闫毅. 生物润滑用聚合物材料研究进展[J]. 日用化学工业（中英文）, 2025, 55(1): 12-25.

Shida Hou, Ping Peng, Yuankang Liu, Jing Yan, Yi Yan. Advances in polymeric materials for bio-lubrication[J]. China Surfactant Detergent & Cosmetics, 2025, 55(1): 12-25.

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