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日用化学工业（中英文）

日用化学工业 ›› 2020, Vol. 50 ›› Issue (4): 255-262.doi: 10.3969/j.issn.1001-1803.2020.04.008

• 开发与应用 • 上一篇    下一篇

女性早白发与生理性白发毛囊脂质多态性研究

马宇晨1,2,王贺聪1,2,李汇柯1,2,何聪芬1,2()   

  1. 1. 北京工商大学 理学院 化妆品系,北京 100048
    2. 北京工商大学 中国化妆品研究中心,北京 100048
  • 收稿日期:2019-08-22 修回日期:2020-03-29 出版日期:2020-04-22 发布日期:2020-04-24
  • 通讯作者: 何聪芬
  • 作者简介:马宇晨（1996-）,女,硕士研究生,电话：18811359316,E-mai：18811359316@163.com。

Study on lipid polymorphism in hair follicles of early white hair and physiological white hair in women

MA Yu-chen1,2,WANG He-cong1,2,LI Hui-ke1,2,HE Cong-fen1,2()   

  1. 1. Department of Cosmetics, School of Science, Beijing Technology and Business University, Beijing 100048, China
    2. China Cosmetics Research Center, Beijing Technology and Business University, Beijing 100048, China
  • Received:2019-08-22 Revised:2020-03-29 Online:2020-04-22 Published:2020-04-24
  • Contact: Cong-fen HE

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摘要：

运用脂质组学方法,系统分析了早白发与生理性白发女性黑白发脂质成分差异以及女性白发毛囊脂质组成和年龄的关系,为不同年龄阶段女性白发的预防以及脂质添加的发用产品研发提供新思路。实验采用UPLC-QTOF-MS（超高效液相色谱-串联飞行时间质谱）结合OPLS-DA（正交偏最小二乘判别分析）模式对不同样本毛囊脂质进行差异性分析,发现早白发中,其黑发（Y-B）与白发（Y-W）中甘油二酯（DG）和磷脂酰丝氨酸（PS）含量差异显著,其中PS含量为Y-W高于Y-B,DG相反;在生理性白发中,其黑发（O-B）与白发（O-W）中PS差异最显著,其次为甘油三酯（TG）,且二者含量均为O-W高于O-B;在生理性白发（O-W）与早白发（Y-W）中,PS含量差异最显著,且O-W高于Y-W。结果显示,PS含量均为白发高于黑发,且生理性白发高于早白发,推测PS增加可能与白发产生相关;DG对早白发的影响更大,而TG对生理性白发的影响更大,这一点对于研发有针对性的脂质添加发用产品具有一定的借鉴意义。

关键词: 女性, 多态性脂质, 早白发, 生理性白发, 超高效液相色谱-串联飞行时间质谱, 发用产品

Abstract:

The lipidomics method was used to systematically analyze the difference in lipid composition of black and white hair between early white hair and physiological white hair females, and the relationship between lipid composition and age of female white hair follicle. The aim of the study was to prevent female white hair in different age stages, and to provide new ideas of the research and development of lipid added hair product. UPLC-QTOF-MS combined with OPLS-DA （orthogonal partial least squares discriminant analysis） model was used to analyze the difference of hair follicle lipids in different samples. There were significant differences in the contents of glycerol diester （DG） and phosphatidylserine （PS） between black hair （Y-B） and white hair （Y-W）. The content of PS in Y-W was higher than that in Y-B, while that in DG was on the contrary. In physiological white hair, the difference of PS between black hair （O-B） and white hair （O-W） was the most significant, followed by triglyceride （TG）, and the content of O-W was higher than that of O-B. In physiological white hair （O-W） and early white hair （Y-W）, the difference of PS content was the most significant, and the content of O-W was higher than that of Y-W. The results showed that the content of PS in white hair was higher than that in black hair, and the content of physiological white hair was higher than that in early white hair. It was speculated that the increase of PS may be related to the occurrence of white hair; DG had a greater impact on early gray hair, while TG had a greater impact on physiological white hair, which had certain reference significance for the research and development of targeted lipid-added hair products.

Key words: female, polymeric lipid, early white hair, physiological white hair, ultra high performance liquid chromatography-tandem time-of-flight mass spectrometry, hair product

中图分类号: 

  • TQ658.3