复配植物防脱生发原料的制备与功效评价研究

doi:10.13218/j.cnki.csdc.2018.09.008

日用化学工业 ›› 2018, Vol. 48 ›› Issue (9): 521-526.doi: 10.13218/j.cnki.csdc.2018.09.008

复配植物防脱生发原料的制备与功效评价研究

高合意¹,黄健聪²,雷登凤¹,陈志杰²,梁钦智¹,曾飒¹

1.广州栋方生物科技股份有限公司,广东广州 510800;
2.广州市华代生物科技有限公司,广东广州 510053

出版日期:2018-09-20 发布日期:2019-03-19
通讯作者: 曾飒,博士,主要研究方向为绿色化妆品的研制,E-mail:shirly9769@gmail.com。
作者简介:高合意(1982-),男,湖北黄冈人,硕士,主要研究方向为植物活性原料制备及机理研究,E-mail:heygao@163.com。
基金资助:
广州市重大科技专项资助(201605131253060)

Study on preperation and efficacyevaluation of herbal compound material for promoting hair growth

GAO He-yi¹,HUANG Jian-cong²,LEI Deng-feng¹,CHEN Zhi-jie²,LIANG Qin-zhi¹,ZENG Sa¹

1.Guangzhou Ridgepole Biological Technology Co.,Ltd.,Guangzhou,Guangdong 510800,China;
2.Guangzhou Chn-Alternative Biotechnology Co.,Ltd.,Guangzhou,Guangdong 510053,China

Online:2018-09-20 Published:2019-03-19

摘要/Abstract

摘要： 制备生姜汁和何首乌、当归提取液,按特定比例复配为新原料,采用5α-还原酶抑制模型、抗氧化法和动物模型对其进行测试评价。结果表明该新原料可以体外抑制5α-还原酶的活性,且对DPPH自由基具有一定的清除能力;动物模型实验结果表明,样品在体积分数10%和30%下,对毛发生长表现出较明显的促进作用。初步证明了该复配的新原料具有防脱发、促进生发的功效,可用于生发产品的开发。

关键词: 毛发用品, 植物原料, 生发功效, 5α-还原酶, 体外试验

Abstract: The fresh ginger,polygonum multiflorumthunb and angelica sinensis were prepared and formulated into a new raw material according to a specific ratio.The model of 5α-reductase inhibition,anti-oxidant property and animal test were conducted for its promoting hair growth and reducing hair loss efficacy.The results show that this material can inhibit the activity of 5α-reductase in vitro and have a certain ability to scavenge DPPH free radical.It can obviously promote hair growth at volume fractions of 10% and 30% in animal study.In conclusion,it is preliminarily proved that the new raw material can prevent hair loss and promote hair growth,and can be used for the development of hair growth products.

Key words: hair product, herbal material, hair grow efficacy, 5α-reductase, in vitro test

中图分类号:

TQ658.3

高合意, 黄健聪, 雷登凤, 陈志杰, 梁钦智, 曾飒. 复配植物防脱生发原料的制备与功效评价研究[J]. 日用化学工业, 2018, 48(9): 521-526.

GAO He-yi, HUANG Jian-cong, LEI Deng-feng, CHEN Zhi-jie, LIANG Qin-zhi, ZENG Sa. Study on preperation and efficacyevaluation of herbal compound material for promoting hair growth[J]. China Surfactant Detergent & Cosmetics, 2018, 48(9): 521-526.

参考文献

[1] Chen Deqing,Qiu Zijin.Pathogeny and treatment progress of androgenic alopecia [J].Practical Journal of Clinical Medicine,2006,3(5):95-96.
[2] Song Jiquan,Liu Jing,Liu Shengwu,et al.Effect of angelica polysaccharide on human scalp hair growth in vitro [J].China Journal of Leprosy and Skin Diseases,2007(11):960-962.
[3] Liu Li,Zhu Hongxia,Chen Yuyao,et al.Influence of rhizoma zingiberis recens on hair growth of C57BL/6J [J].Journal of Liaoning University of Traditional Chinese Medicine,2013,15(7):42-44.
[4] Zheng Gang,Wang Yichen,Lu Hui,et al.Effects of 30 Chinese herbal medicines on human hair follicle culture in vitro[J].World Latest Medicine Information,2013,13(20):15-18.
[5] Yi Xingping,Xia Longqing.The role of 5α-reductase in androgen metabolism and its application in dermatology [J].Foreign Medical Sciences Section of Dermatology and Venereology,2004(6):375-377.
[6] Kim E J,Kim M K,Jeon Y J,et al.The promoting effect of Ishige sinicola on hair growth [J].Marine Drugs,2013,11(6):1783-1799.
[7] Tang Qingtao.Progress of 5α-reductase inhibitors derived from herbal medicine [J].West China Journal of Pharmaceutical Sciences,2016,31(5):544-547.
[8] Kong Deyun,Li Yonghui,Yang Yifang,et al.Advance in studies on active components for 5α-reductase inhibitors isolated from plants [J].Chinese Traditional and Herbal Drugs,2006,37(11):1740-1744.
[9] Chen Yuxia,Liu Jianhua,Lin Feng,et al.Determination of antioxidant activity of 41 kinds of Chinese herbal medicines by using DPPH and FRAP methods [J].Research and Exploration in Laboratory,2011,30(6):11-14.
[10] Ma Lihua,Qin Weidong.Study on the antioxidant and monosaccharide composition of zingiber officinal roscoe polysaccharide [J].Science and Technology of Food Industry,2010(7):113-118.
[11] Carrasco E,Calvo M I,Blázquez-Castro A,et al.Photoactivation of ROS production in situ transiently activatescell proliferation in mouse skin and in the hair follicle stem cellniche promoting hair growth and wound healing [J].J Invest Dermatol,2015,135(11):2611-2622.
[12] Liu N,Wang L H,Guo L L,et al.Chronic restraint stress inhibits hair growth via substance P mediated by reactive oxygen species in mice [J].Plos One,2013,8(4):e61574.
[13] Yu Rutong.Oxidative stress and apoptosis [J].Chinese Journal of Postgraduates of Medicine,2000,23(9):47-50.
[14] Cheng Shujun.Guides of alternative methods stangards for cosmetics assessment [M].Beijing:China Zhijian Publishing House,2017:297-299.
[15] Boisvert W A,Yu M,Choi Y,et al.Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice [J].Bmc Complementary & Alternative Medicine,2017,17(1):109.
[16] MadaanA,Joshi V,Kishore A,et al.In vitro hair growth promoting effects of naringenin and hesperetin on human dermal papilla cells and keratinocytes [J].American Journal of Dermatology and Venereology,2017,6(3):51-57.
[17] Orasan M S,Bolfa P,Coneac A,et al.Topical products for human hair regeneration:A comparative study on an animal model [J].Annals of Dermatology,2016,28(1):65-73.
[18] He Hongmei,Zhu Hongxia,Liu Qiang,et al.Influence of the extract of polygoni multiflori radix on follicle growth and hair growth of C57BL/6J [J].Chinese Journal of Experimental Traditional Medical Formulae,2012,18(23):216-219.
[19] Kang Jung Il,Kim Sang Cheol,Kim Min Kyoung,et al.Effect of dieckol,a component of ecklonia cava,on the promotion of hair growth [J].International Journal of Molecular Sciences,2012,13(5):6407-6423.

复配植物防脱生发原料的制备与功效评价研究

Study on preperation and efficacyevaluation of herbal compound material for promoting hair growth

PDF (PC)

赞

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 8

Metrics

本文评价

推荐阅读 10

[1]	马铃, 沈胡驰, 陈殿松, 杨井国, 王靖. 超声辅助酶法提取茶麸黄酮及其对Ⅱ型5α-还原酶抑制活性[J]. 日用化学工业（中英文）, 2023, 53(3): 308-315.
[2]	林铌,罗飞亚,曹春然,胡宇驰. 基于in vitro和in silico技术的化学品眼刺激性评价替代方法研究[J]. 日用化学工业, 2022, 52(9): 1016-1022.
[3]	李雪,王燕萍,杨兆均,韩佳冰,李文,胡芳弟. 2014—2021年含植物原料的国产普通化妆品现状分析[J]. 日用化学工业, 2022, 52(8): 875-881.
[4]	赵大敏,王学东,翟春涛. 祛痘中草药的筛选及其在治疗痤疮中的应用[J]. 日用化学工业, 2021, 51(6): 522-527.
[5]	高合意,雷登凤,程树军,陈志杰,刘仁龙. 当归提取物对毛发生长作用的体外与体内研究[J]. 日用化学工业, 2020, 50(12): 867-874.
[6]	赵斯琪,孟宏,易帆. 计算机辅助药物设计用于化妆品植物源功效原料筛选的建议[J]. 日用化学工业, 2019, 49(4): 253-258.
[7]	何文丹,刘磊,杨舒颜,唐颖. 化妆品功效评价（XI）——体外试验技术在发用化妆品功效评价中的应用[J]. 日用化学工业, 2019, 49(1): 5-7.
[8]	邓小锋, 孟宏, 李丽, 刘有停, 董银卯. 炮制技术在化妆品植物原料开发中的应用[J]. 日用化学工业, 2015, 45(4): 226-229.