高效液相色谱-串联质谱法测定香水中24种香料类过敏原物质残留量

doi:10.13218/j.cnki.csdc.2018.08.010

Abstract

Abstract: A method of simultaneous determination of 24 allergens in perfume was established with high performance liquid chromatography tandem mass spectrometry.The target compounds were extracted with acetonitrile and determined with HPLC-MS/MS (MRM mode,ESI) with external standard method.The results show that,good linear relationship between concentration and peak area ratio is obtained in the range of 1.0~5.0 mg/L for the 24 allergens.The instrument detection limit is 1.0 mg/L and the method detection limit is 5.0 mg/kg.The limit of quantitation (LOQ) is 15.0 mg/kg.The average recoveries of 24 allergens are 85.9%~110.0% at spiked levels of 5,10 and 20 mg/kg with relative standard derivations (RSDs) of 5.5%~12.0% (n=10).

Key words: perfume, allergen, flavor, high performance liquid chromatography tandem mass spectrometry

CLC Number:

TQ658

WANG Yu-jian,LIANG Zhen-gang,FU Ling-mei,DONG Cun-zhu. Determination of 24 allergens in perfume with high performance liquid chromatography tandem mass spectrometry[J].China Surfactant Detergent & Cosmetics, 2018, 48(8): 472-477.

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Determination of 24 allergens in perfume with high performance liquid chromatography tandem mass spectrometry

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