含茶皂素洗发水的安全性及头皮护理功效评价

doi:10.3969/j.issn.1001-1803.2021.04.011

Abstract

Abstract:

In this study, the skin irritation and eye irritation of tea saponin were studied by using alternative models （including Episkin^TM reconstructed human epidermal model and chicken embryo chorioallantoic membrane test）. The results show that 2%-10% tea saponin solution shows no skin irritation, and tea saponin solution less than 2% （mass fraction） does not exhibit eye irritation. Then, a shampoo containing 5.0% （mass fraction） tea saponin was prepared. By combined sensory evaluation, microscopic scalp observation and instrument test, the efficacy of tea saponin shampoo on scalp care was evaluated. The results show that the shampoo containing tea saponin shows good efficacy in removing dandruff, controlling sebum, relieving itching, lowering scalp sensitivity and improving barrier function. The above effects may be related to the biological activities of tea saponin, such as antibacterial, anti-inflammatory and anti-oxidation. This study can provide basic data for the safety and scalp care efficacy of tea saponin in shampoo.

Key words: tea saponin, shampoo, skin/eye irritation, scalp care efficacy

CLC Number:

TQ658

YANG Jing-guo,SHEN Hu-chi,CHEN Dian-song,ZHAO E,CAI Zhen-zi,WANG Jing. Safety and scalp care efficacy evaluation of shampoos containing tea saponins[J].China Surfactant Detergent & Cosmetics, 2021, 51(4): 331-337.

Figures/Tables 7

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References 14

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	w（空白对照组）/%	w（茶皂素组）/%
水	至100	至100
月桂醇聚醚硫酸酯钠（2EO,70%）	20.00	13.00
茶皂素	—	5.00
月桂酰肌氨酸钠	5.00	5.00
椰油酰胺丙基甜菜碱	4.00	4.00
椰油基葡糖苷（C₁₂-C₁₄）	2.00	2.00
季戊四醇四硬脂酸酯	0.20	1.75
香精	0.80	0.80
苯甲酸钠	0.30	0.30
聚季铵盐-10	0.60	0.60
CE-1391（陶氏）	2.00	2.00
CE-1874（陶氏）	2.00	2.00
柠檬酸	0.95	0.90
乙二胺四乙酸二钠	0.10	0.10

样品名称	secH/s	secL/s	secC/s	IS	刺激程度
0.9% NaCl（阴性对照）	301	301	301	0	无眼刺激
1% SLS（阳性对照）	30	66	125	15.28	重度眼刺激
2% AES（对照组）	60	90	150	13.47	重度眼刺激
0.5%茶皂素	301	301	301	0	无眼刺激
1.0%茶皂素	301	301	301	0	无眼刺激
2.0%茶皂素	180	270	301	2.74	轻度眼刺激

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Safety and scalp care efficacy evaluation of shampoos containing tea saponins

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