三羟基硬脂精在二合一香波中的应用

doi:10.3969/j.issn.1001-1803.2022.05.009

Abstract

Abstract:

Trihydroxystearin is a kind of food additive which is safe and inexpensive. It has been widely used as an anti-crystallizer for many types of oils, such as vegetable oil and edible salad oil. In daily chemical products, trihydroxystearin can effectively provide thixotropy and prevent the occurrence of sedimentation. Recent research has shown that it can be used as a suspending agent in wash and protect, two-in-one shampoos. As a suspending agent, trihydroxystearin is effective to suspend silicone oil, pearlescent agents, anti-dandruff agents and other shampoo components. Compared with other commonly used suspending agents for shampoos, trihydroxystearin is more convenient and has less influence on the physical and chemical properties of the shampoos. Herein, a comparative study for the application of trihydroxystearin and other suspending agents, such as carbomer （Carbomer 940）, acrylate/C_10~30 alkyl acrylate cross-linked polymer （Ultrez 21）, acrylate copolymer （Aqua SF-1） and dihydrogenated tallow phthalic acid amide （TAB-Ⅱ）, in 2-in-1 shampoo was made. Carbomer 940 and Ultrez 21 tend to absorb moisture and agglomerate. For Aqua SF-1, it is difficult to eliminate the foam produced by shearing and stirring in large-scale production, which leads to long de-foaming time and high energy consumption. TAB-Ⅱ can reduce the foaming properties and cleaning ability of shampoos. Therefore, trihydroxystearin is more suitable for use as a suspending agent in a lotion, and as a stabilizer in a two-in-one shampoo compared with the chemicals mentioned above. The results show that, stable two-in-one shampoo can be made by adding 0.2% trihydroxystearin as the suspending agent, the amount of which is less than other suspending agents. The safety of trihydroxystearin was studied by using the red blood cell hemolysis test and the human safety patch test. The results show that trihydroxystearin can decrease the irritation of surfactants in the red blood cell hemolysis test, and it has not irritation to the skin in the human safety patch test, indicating that it is safe. Finally, the sensory evaluation of the shampoo with trihydroxystearin was carried out. It is found that there is no significant difference in the feeling of washing in the sensory evaluation test versus other products. In conclusion, trihydroxystearin is more convenient and effective as a suspending agent in the shampoo, and it is safe and has less impact to the physical and chemical properties of the shampoo than other chemicals.

Key words: trihydroxystearin, shampoo, suspension, mildness

CLC Number:

TQ658

Zhong Huanhuan,Chen Yeting,Chen Youting,Yu Tian,Li Ru,Gong Shengzhao. Research on application of trihydroxystearin in 2-in-1 shampoo[J].China Surfactant Detergent & Cosmetics, 2022, 52(5): 521-528.

Figures/Tables 11

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References 8

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相	原料商品名	原料INCI名称	w/%
A相	JK-140K	瓜儿胶羟丙基三甲基氯化铵	0.30
A相	去离子水	水	至100.00
B相	AES	月桂醇聚醚硫酸酯钠	20.00
C相	EDTA二钠	EDTA二钠	0.15
	C-11S	椰油酰胺甲基MEA	1.50
	LANETTEO	鲸蜡硬脂醇	0.50
	TEGIN EGS	乙二醇二硬脂酸酯	1.50
D相	ZPT	吡硫鎓锌	1.00
	CAB	椰油酰胺丙基甜菜碱	5.00
	MEM-7137	聚二甲基硅氧烷	2.00
	MEM-1785	聚二甲基硅氧烷醇	2.50
	柠檬酸	柠檬酸	适量
	柠檬酸钠	柠檬酸钠	适量
	DMDMH	DMDM乙内酰脲	0.20
	氯化钠	氯化钠	适量
	GGC-55712	香精	0.70
E相	悬浮剂	三羟基硬脂精/二（氢化牛脂基）邻苯二甲酸酰胺/卡波姆/丙烯酸（酯）类共聚物/丙烯酸（酯）类/C_10~30烷醇丙烯酸酯交联聚合物	0.10~2.00

相	原料商品名	原料INCI名称	w/%
A相	JK-140K	瓜儿胶羟丙基三甲基氯化铵	0.30
A相	去离子水	水	至100.00
B相	AES	月桂醇聚醚硫酸酯钠	20.00
C相	EDTA二钠	EDTA二钠	0.15
	C-11S	椰油酰胺甲基MEA	1.50
	LANETTEO	鲸蜡硬脂醇	0.50
	TEGIN EGS	乙二醇二硬脂酸酯	1.50
D相	ZPT	吡硫鎓锌	1.00
	CAB	椰油酰胺丙基甜菜碱	5.00
	MEM-7137	聚二甲基硅氧烷	2.00
	MEM-1785	聚二甲基硅氧烷醇	2.50
	柠檬酸	柠檬酸	适量
	柠檬酸钠	柠檬酸钠	适量
	DMDMH	DMDM 乙内酰脲	0.20
	氯化钠	氯化钠	0.10
	GGC-55712	香精	0.70
E相	悬浮剂	三羟基硬脂精	0.10~0.50

评分等级	皮肤反应
0	阴性反应
1	可疑反应,仅有微弱红斑
2	弱阳性反应（红斑反应）：红斑、浸润、水肿、可有丘疹
3	强阳性反应（疱疹反应）：红斑、浸润、水肿、丘疹;反应可超出受试区
4	极强阳性反应（融合性疱疹反应）：明显红斑、严重浸润、水肿、融合性疱疹;反应超出受试区

悬浮剂	固含量（w） /%
	0.5			0.4			0.3			0.2			0.1
	-15℃	48℃	循环	-15℃	48℃	循环	-15℃	48℃	循环	-15℃	48℃	循环	-15℃	48℃	循环
三羟基硬脂精	√	√	√	√	√	√	√	√	√	√	√	√	√	╳	╳
SF-1	√	√	╳	√	√	╳	√	╳	╳	√	╳	╳	√	╳	╳
Carbomer 940	√	√	√	√	√	╳	√	╳	╳	√	╳	╳	√	╳	╳
U-21	√	√	√	√	√	╳	√	╳	╳	√	╳	╳	√	╳	╳
TAB-Ⅱ	√	╳	╳	√	╳	╳	√	╳	╳	√	╳	╳	√	╳	╳

悬浮剂	泡沫高度/mm
悬浮剂	初始	1 min	5 min	10 min
空白样	164.00±3.61 ^{b c}	162.00±4.00^b	159.67±4.04^b	155.00±4.58^b
三羟基硬脂精	162.00±2.65^b	161.67±2.31^b	161.00±2.65^{b c}	158.00±2.00^{b c}
Aqua SF-1	167.00±3.00^{b c d}	167.00±3.00^{b c}	166.00±3.00 ^{c d}	163.00±2.00^c
Carbomer 940	168.00±1.73^{c d}	166.33±1.53^{b c}	165.00±1.00^{c d}	163.00±1.00^c
Ultrez 21	170.00±2.00^d	169.50±0.71 ^c	167.00±3.00^d	163.00±3.00^c
TAB-Ⅱ	150.00±4.00 ^a	146.33±3.21^a	143.00±2.00 ^a	135.33±1.53^a

Research on application of trihydroxystearin in 2-in-1 shampoo

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	HC₅₀/（mg/L）	DI/%	L/D	刺激分级	刺激分级标准
空白组	1 147	96.37	11.91	微刺激性	L/D>100：无刺激性; 10<L/D≤100：微刺激性; 1<L/D≤10：轻度刺激性; 0.1<L/D≤1：中度刺激性; L/D≤0.1：重度刺激性
三羟基硬脂精	1 479.05	95.98	15.41	微刺激性
Aqua SF-1	598	96.02	6.22	轻度刺激性
Carbomer 940	990	96.42	10.27	微刺激性
Ultrez 21	1 102	95.22	11.58	微刺激性
TAB-Ⅱ	1 167	95.88	12.17	微刺激性

三羟硬脂精质量分数/%	HC₅₀/（mg/L）	DI/%	L/D	刺激分级	刺激分级标准
0	1 337.76	104.76	12.77	微刺激性	L/D>100：无刺激性; 10<L/D≤100：微刺激性; 1<L/D≤10：轻度刺激性; 0.1<L/D≤1：中度刺激性; L/D≤0.1：重度刺激性
0.1	2 625.54	104.63	25.09	微刺激性
0.2	2 781.99	104.79	26.55	微刺激性
0.3	2 912.78	106.48	27.36	微刺激性
0.4	2 924.78	103.25	28.33	微刺激性

	空白组		含0.2%三羟基硬脂精的香波		含0.4%三羟基硬脂精的香波
	24 h	48 h	24 h	48 h	24 h	48 h
皮肤出现可疑斑点人数	0	0	0	0	0	0
皮肤未出现可疑斑点人数	30	30	30	30	30	30

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