双重响应性纳米凝胶的制备及其结构色调控

doi:10.3969/j.issn.1001-1803.2021.09.007

Abstract

Abstract:

A weakly acidic monomer L-N-acryloyl phenylalanine （APhe） was synthesized. Poly（NIPA-co-APhe） copolymer nanogels were synthesized by emulsion precipitation copolymerization of the monomer Aphe with the thermosensitive monomer N-isopropylacrylamide （NIPA）. The structure and morphology of the nanogels prepared were characterized by IR and TEM, respectively. The results show that the particles of nanogels are spherical and monodispersed. The nanogels were also analyzed by particle size analyzer. It is found that the nanogels have good temperature/pH sensitivities. That is, the particle size is gradually decreased with the increase of temperature, and the particle size is first increased and then decreased with the increase of pH. The structural color was characterized by optical fiber spectrometer. It is found that the structural color of the nanogels can be adjusted by varying the monomer ratio and pH value. That is, the particle size is gradually increased with the increase of molar fraction of monomer APhe, and the color is gradually changed from green to blue as the compression degree of the particles is increased. Furthermore, it is important to observe that the Poly（NIPA-co-APhe） nanogels even keep the structural color in the case of undergoing a temperature-induced phase transition.

Key words: nanogel, thermosensitive, pH sensitive, structural color

CLC Number:

TQ427.2

Ding Hanxue,Li Xueting,Lu Xihua. Preparation and tunable structural color of dual-responsive nanogels[J].China Surfactant Detergent & Cosmetics, 2021, 51(9): 852-858.

Figures/Tables 13

Fig. 1

Tab. 1

Fig. 2

Fig. 3

Fig. 4

Fig. 5

Fig. 6

Fig. 7

Fig. 8

Fig. 9

Fig. 10

Fig. 11

Fig. 12

References 14

[1]	Kanazawa R, A Sasaki, H Tokuyama. Preparation of dual temperature/pH-sensitive polyampholyte gels and investigation of their protein adsorption behaviors[J]. Separation and Purification Technology, 2012, 96:26-32. doi: 10.1016/j.seppur.2012.05.016
[2]	Xiong W. Dual temperature/pH-sensitive drug delivery of poly(N-isopropylacrylamide-co-acrylic acid) nanogels conjugated with doxorubicin for potential application in tumor hyperthermia therapy[J]. Colloids Surf B Biointerfaces, 2011, 84(2): 447-453. doi: 10.1016/j.colsurfb.2011.01.040
[3]	Luo C H. Utilization of L-serinyl derivate to preparing triple stimuli-responsive hydrogels for controlled drug delivery[J]. Journal of Polymer Research, 2019, 26(12).
[4]	Pilipenko I M. Thermo- and pH-sensitive glycosaminoglycans derivatives obtained by controlled grafting of poly(N-isopropylacrylamide)[J]. Carbohydrate Polymers, 2020, 248(9): 116764. doi: 10.1016/j.carbpol.2020.116764
[5]	Pavan Rudhrabatla V S A. Fabrication and characterisation of curcumin loaded pH dependent sodium alginate-g-poly(acryloyl phenylalanine)-cl-ethylene glycol vinyl ether-co- hydroxyethyl acrylate hydrogels and their in-vitro, in-vivo and toxicological evaluation studies[J]. Journal of Drug Delivery Science and Technology, 2019, 51:438-453. doi: 10.1016/j.jddst.2019.03.020
[6]	Such G K. Interfacing materials science and biology for drug carrier design[J]. Adv Mater, 2015, 27(14): 2278-2297. doi: 10.1002/adma.v27.14
[7]	Wu M. Injectable and self-healing nanocomposite hydrogels with ultrasensitive pH-responsiveness and tunable mechanical properties: implications for controlled drug delivery[J]. Biomacromolecules, 2020, 21(6): 2409-2420. doi: 10.1021/acs.biomac.0c00347
[8]	Dehghan-Baniani D. Injectable in situ forming kartogenin-loaded chitosan hydrogel with tunable rheological properties for cartilage tissue engineering[J]. Colloids Surf B Biointerfaces, 2020, 192:111059. doi: 10.1016/j.colsurfb.2020.111059
[9]	Bordat A. Thermoresponsive polymer nanocarriers for biomedical applications[J]. Advanced Drug Delivery Reviews, 2019, 138:167-192. doi: 10.1016/j.addr.2018.10.005
[10]	Li X. Redox/temperature responsive nonionic nanogel and photonic crystal hydrogel: Comparison between N, N′-Bis(acryloyl)cystamine and N, N′-methylenebisacrylamide[J]. Polymer, 2018, 137:112-121. doi: 10.1016/j.polymer.2017.12.066
[11]	Radecki M. Temperature-induced phase transition in hydrogels of interpenetrating networks of poly(N-isopropylacrylamide) and polyacrylamide[J]. European Polymer Journal, 2015, 68:68-79. doi: 10.1016/j.eurpolymj.2015.04.019
[12]	Sun S T. Chain collapse and revival thermodynamics of poly(n-isopropylacrylamide) hydrogel[J]. Journal of Physical Chemistry B, 2010, 114(30): 9761-9770. doi: 10.1021/jp103818c
[13]	Huynh C T. pH/temperature-sensitive 4-arm poly(ethylene glycol)-poly(amino urethane) copolymer hydrogels[J]. Polymer, 2010, 51(17): 3843-3850. doi: 10.1016/j.polymer.2010.06.042
[14]	G Fundueanu, M Constantin, P Ascenzi. Preparation and characterization of pH- and temperature-sensitive pullulan microspheres for controlled release of drugs[J]. Biomaterials, 2008, 29(18): 2767-2775. doi: 10.1016/j.biomaterials.2008.03.025 pmid: 18396330

样品	NIPA		APhe		BIS		SDS	APS	H₂O
样品	摩尔比/%	m/g	摩尔比/%	m/g	摩尔比/%	m/g	m/g	m/g	m/g
PNA2	96	1.084 8	2	0.043 8	2	0.02	0.05	0.05	100
PNA6	92	1.039 6	6	0.131 4	2	0.02	0.05	0.05	100
PNA8	90	1.017 0	8	0.175 2	2	0.02	0.05	0.05	100
PNA10	88	0.994 4	10	0.219 0	2	0.02	0.05	0.05	100
PNA15	83	0.937 9	15	0.328 5	2	0.02	0.05	0.05	100
PNA23	75	0.847 5	23	0.503 7	2	0.02	0.05	0.05	100

Preparation and tunable structural color of dual-responsive nanogels

RichHTML

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 13

References 14

Related Articles 1

Metrics

Comments

Recommended 10