薰衣草精油和亚洲薄荷精油促毛发生长作用的研究

doi:10.3969/j.issn.1001-1803.2020.08.005

Abstract

Abstract:

The effects of lavender （Lavandula angustifolia） essential oil and Asian mint （Mentha asiatica） essential oil on hair growth were studied by cell experiment in vitro and hair loss mouse model. The effects of two essential oils on the secretion of vascular endothelial growth factor （VEGF） and keratinocyte growth factor （KGF） of human immortalized keratinocytes were detected by cell experiment. The effects of two essential oils on hair regrowth length, histological changes of skin in depilated area, number of hair follicles, thickness of dermis, and expressions of skin VEGF and KGF were studied by mouse model. The results show that both lavender essential oil and Asian mint essential oil can promote hair elongation, increase the number of hair follicles and dermal thickness in the depilated area, and prolong the anagen hair cycle in mice. However, their mechanisms might be different. Lavender essential oil promotes the secretion of KGF, while Asian mint essential oil increases the secretion of VEGF. The results of animal experiments are consistent with those of cell experiments. It demonstrates that both lavender essential oil and Asian mint essential oil have hair-promoting effects.

Key words: lavender essential oil, Asian mint essential oil, hair growth, human immortalized keratinocytes, hair loss mouse model

CLC Number:

TQ658

LI Rui,ZHANG Nan,YAO Lei,LI Yu-hong. Study on the hair growth promotion effect of lavender essential oil and Asian mint essential oil[J].China Surfactant Detergent & Cosmetics, 2020, 50(8): 536-541.

Figures/Tables 7

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References 24

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ρ （精油） / （mg·L^-1）	薰衣草精油		亚洲薄荷精油
ρ （精油） / （mg·L^-1）	RGR/%	毒性分级	RGR/%	毒性分级
0	100.00± 7.40	0	100.00±12.49	0
0.01	88.98± 8.10	1	113.41±19.52	0
0.1	84.71±10.66	1	115.60± 4.85	0
1	86.23± 8.41	1	96.52± 8.69	1
10	95.18±12.77	1	106.96± 2.08	0
50	80.58± 1.19	1	98.97±13.75	1
100	91.87± 3.26	1	100.26±11.72	0
500	76.31± 5.64^*	2	89.04± 7.59	1

	ρ （VEGF） / （μg·L^-1）
	0 mg/L	0.01 mg/L	0.1 mg/L	1 mg/L	10 mg/L	100 mg/L
薰衣草精油	3.70±0.11	3.97±0.08	4.21±0.47	4.02±0.15	3.95±0.15	4.14±0.47
亚洲薄荷精油	2.66±1.14	4.74±1.77^*	4.54±1.47	3.35±0.54	4.97±1.02^*	3.67±1.04

	ρ （KGF） / （μg·L^-1）
	0 mg/L	0.01 mg/L	0.1 mg/L	1 mg/L	10 mg/L	100 mg/L
薰衣草精油	2.84±0.20	3.60±0.56^**	3.39±0.22^*	3.41±0.26^*	3.62±0.21^**	3.73±0.25^**
亚洲薄荷精油	2.57±0.51	2.59±0.60	2.52±0.62	2.76±0.13	3.12±0.77	2.57±0.58

组别	毛发长度/mm
组别	12 d	15 d	18 d	21 d
对照组	1.79±0.19	2.88±0.35	4.91±0.49	5.75±0.51
阳性对照组	2.09±0.30^**	3.37±0.58^**	5.11±0.49	5.83±0.56
1%薰衣草精油组	1.96±0.25^*	3.50±0.93^**	5.22±0.69^*	6.08±0.52^*
5%薰衣草精油组	1.94±0.31^*	2.78±0.56	4.48±0.80^**	5.34±0.76^**
10%薰衣草精油组	1.89±0.27	2.94±0.38	4.84±0.72	5.56±0.76
1%亚洲薄荷精油组	2.09±0.27^**	3.06±0.37	4.77±0.60	5.63±0.48
5%亚洲薄荷精油组	1.94±0.51^*	3.01±0.28	4.66±0.47	5.70±0.37
10%亚洲薄荷精油组	1.77±0.17	3.15±0.61^*	4.55±0.62^*	5.30±0.78^**

组别	毛囊数量/（个/视野）	真皮厚度/μm
对照组	10.60± 2.51	246.19± 20.02
阳性对照组	28.20±11.30^*	336.91± 39.68^*
1%薰衣草精油组	35.80±16.81^**	352.38± 41.41^*
5%薰衣草精油组	24.00± 6.53	331.99± 39.85^*
10%薰衣草精油组	29.67±11.43^*	300.70± 50.90
1%亚洲薄荷精油组	31.00±11.92^*	366.67± 53.98^**
5%亚洲薄荷精油组	30.50±20.14^*	390.48±110.77^**
10%亚洲薄荷精油组	15.80± 5.22	302.38± 48.42

Study on the hair growth promotion effect of lavender essential oil and Asian mint essential oil

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组别	ρ （VEGF） / （μg·L^-1）	ρ （KGF） / （μg·L^-1）
对照组	0.74±0.13	0.34±0.05
阳性对照组	0.91±0.08	0.22±0.07
1%薰衣草精油组	1.06±0.14	0.59±0.13^*
1%亚洲薄荷精油组	1.36±0.50^*	0.43±0.13

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