三皮素对抗痤疮的功效研究

doi:10.3969/j.issn.1001-1803.2019.01.007

Abstract

Abstract:

The solution of antisebum GMP which consists of the extracts from the peels of Garcinia Mangostana, Magnolia Officinalis, and Punica Granatum has been used to study its efficacy in anti-lipid peroxidation, oil control, anti-bacteria and anti-inflammation. The results show that GMP has significant inhibitory effect on lipid peroxidation at the mass concentration of 1%. After the treatment of sebaceous gland cells with GMP （0.1%） for 24 h, the mRNA expression levels of insulin like receptor （IGF1R） and peroxisome proliferator activated receptor （PPARγ） can be remarkably down-regulated to reduce the intracellular lipid synthesis in the cells. The minimum inhibitory concentration （MIC） of GMP on Propionibacterium acnes is 0.03%. On the model of macrophage inflammation induced by Propionibacterium acnes, GMP can also inhibit the expression of interleukin 6 （IL6）, prostaglandin E2 （PGE2） and nitric oxide （NO） in a dose-dependent manner. Therefore, as a natural active ingredient, GMP can play a role in anti-acne aiming at the various factors in the pathogenesis of acne vulgaris.

Key words: cosmetic additive, GMP, acne, anti-inflammatory

CLC Number:

TQ658.2

Yi-na LU,Guang-yin WANG,Hong XIE,Zhi-yong XIE. Efficacy study of antisebum GMP in the treatment of acne vulgaris[J].China Surfactant Detergent & Cosmetics, 2019, 49(1): 29-33.

Figures/Tables 6

Tab. 1

Fig. 1

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Tab. 2

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References 17

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	w（三皮素）/%						w（Vc）/%
	0	0.1	0.3	1	3	10	1
A	1.108	0.967	0.622	0.583	0.387	0.365	0.194
抑制率/%	0.00	11.24^**	42.84^**	46.44^**	64.42^**	66.53^**	82.45^**

痤疮丙酸杆菌浓度× 10^-8/（CFU·mL^-1）	c（NO）/（μmol·L^-1）	ρ（IL6）/（ng·L^-1）	ρ（PGE2）/（ng·L^-1）
0	0.06	181.56	263.3
0.5	9.58^**	2 419.24^**	3 476.3^**

Efficacy study of antisebum GMP in the treatment of acne vulgaris

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