十二烷基硫酸钠对角质细胞基因表达的影响及作用通路研究

doi:10.13218/j.cnki.csdc.2016.06.007

Abstract

Abstract: Detection of total RNA of keratinocytes after irritation of sodium dodecyl sulfate (SDS) was conducted utilizing human mRNA micro array to study the effect of SDS on gene expression of keratinocytes and its signaling pathway,as well as to predict the possibility of inducing disease by the SDS.Results showed that expression of 605 genes are significantly up regulated and 368 genes are significantly down regulated after exposing to SDS.The signals are transformed mainly by TNF signaling pathway.Ten critical genes (IL-6,TNF,CCL5,CCL20,CXCL8,CXCL3,CSF2,CSF1,TNFAIP3 and NLRC4) are screened by the pathways.Abnormal expression of these genes will affect the development of inflammation and activation of immunity.Possibly,irritation of SDS may cause atopic dermatitis as well as promotion of allergies and autoimmune disease.

Key words: sodium dodecyl sulfate, keratinocyte, irritation, micro array, inflammation

CLC Number:

TQ423.11

ZHAO Dan,SU Ning,ZHANG Jia-chan,LI Meng,HUO Tong,WANG Chang-tao. Study with respect to effect of sodium dodecyl sulfate on gene expression of keratinocytes and its signaling pathway[J].China Surfactant Detergent & Cosmetics, 2016, 46(6): 334-338.

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Study with respect to effect of sodium dodecyl sulfate on gene expression of keratinocytes and its signaling pathway

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