Abstract: Preparation of liposome for encapsulating V_E was conducted under assistance of ultrasonic wave.Extent of encapsulation and particle size were taken as evaluation criteria.Via single factor experiments,relatively better conditions were identified.Mass ratio of the ingredients is:m(soybean lecithin):m(V_E):m(cholesterol):m(polyvinyl alcohol)=6:3:3:2.Volume ratio of solvents is:V(chloroform):V(water)=1:3.The mass fraction of V_E is 8.8% in system.Ultrasonic treatment time is 2 min.Extent of encapsulation achieves 86.8% with particle size of 62.9 nm under above conditions,and the shape of the liposome product is round balls.Suitable temperature for storing the liposome product is recommended as 4 ℃.

Key words: additive of cosmetics, vitamin E, liposome, encapsulation extent, particle size