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日用化学工业（中英文）

日用化学工业 ›› 2014, Vol. 44 ›› Issue (5): 278-281.doi: 10.13218/j.cnki.csdc.2014.05.062

• 开发与应用 • 上一篇    下一篇

救必应提取物安全性研究

徐春生, 徐文霞   

  1. 广州市牙博士口腔护理研究院,广东 广州 510897
  • 收稿日期:2013-11-13 发布日期:2019-04-10
  • 作者简介:徐春生(1966-),男,安徽人,高级工程师,硕士,电话:13866151208,E-mail:xcs6603@163.com。

Study on safety of extract of Ovateleaf Holly Bark

XU Chun-sheng, XU Wen-xia   

  1. Guangzhou Qiancai Dental Doctor Oral Care Research Institute,Guangzhou,Guangdong 510897,China
  • Received:2013-11-13 Published:2019-04-10

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摘要： 通过急性毒性试验、亚慢性毒性试验、沙门氏菌/回复突变试验、细胞微核试验、口腔黏膜影响试验和牙龈黏膜影响试验等,对救必应提取物在牙膏中使用的安全性进行了评价。结果表明,救必应提取物属于实际无毒级物质,无基因突变和染色体畸变的危险,对口腔黏膜和牙龈黏膜无刺激,可安全应用于牙膏等口腔护理产品之中。

关键词: 牙膏, 救必应, 安全性评价

Abstract: For evaluating the safety of the extract of Ovateleaf Holly Bark that adopted in toothpaste,the acute toxicity test,sub-chronic toxicity test,salmonella typhimurium/reverse mutation assay,mammalian erythrocyte micronucleus test,oral mucosa impact test and gingival mucosa impact test were conducted.Test results showed that the extract of Ovateleaf Holly Bark belongs to practically non-toxic grade material,and there is no danger of gene mutation and chromosome aberration,no stimulation to mouth mucosa and gingiva.So it can be safely applied to oral care product.

Key words: toothpaste, Ovateleaf Holly Bark, safety evaluation

中图分类号: 

  • TQ658.4