油茶籽油-神经酰胺纳米乳液制备及研究

doi:10.3969/j.issn.2097-2806.2025.06.008

摘要/Abstract

摘要： 为提高油茶籽油（Camellia oleifera seed oil，CSO）在化妆品领域的开发和应用，以CSO为化妆品基质油，并配伍神经酰胺（Ceramide，Cer），采用高压均质法制备并优化了CSO-Cer纳米乳液的最佳配方和条件。结果显示：在均质压力100 MPa，循环次数为7次，CSO质量分数为15%，Cer添加量为1%，氢化卵磷脂质量分数为4%，胆固醇质量分数为0.2%，甘油质量分数为25%的条件下，得到具有最优粒径和稳定性的纳米乳液。此乳液粒径为124.7 nm、多分散指数为0.108，Zeta电位为-55.7 mV。进一步测试发现，该CSO-Cer纳米乳液展现出良好的保湿特性和透皮性能。因此，基于CSO的CSO-Cer纳米乳液是一种潜在的新型功能性化妆品乳液，为后续CSO在化妆品领域的应用提供了重要的技术参考。

关键词: 油茶籽油, 神经酰胺, 纳米乳液, 保湿性, 透皮性

Abstract:

In order to enhance the development and application of Camellia oleifera seed oil （CSO） in the field of cosmetics, the study utilizes CSO as the cosmetic base oil and combines it with ceramide （Cer）. High-pressure homogenization was employed to prepare and optimize the best formula and conditions for the CSO-Cer nanoemulsion. The results show that under the conditions of homogenization pressure at 100 MPa, 7 cycles, a CSO mass fraction of 15%, a Cer addition of 1%, a hydrogenated lecithin mass fraction of 4%, a cholesterol mass fraction of 0.2%, and a glycerol mass fraction of 25%, a nanoemulsion with optimal particle size and stability is obtained. This emulsion has a particle size of 124.7 nm, a polydispersity index of 0.108, and a Zeta potential of -55.7 mV. Further testing reveals that the CSO-Cer nano-emulsion exhibits excellent moisturizing and transdermal properties. Consequently, the CSO-based CSO-Cer nanoemulsion is a potential new type of functional cosmetic emulsion, providing significant technical reference for the subsequent application of CSO in the field of cosmetics.

Key words: Camellia oleifera seed oil, ceramide, nanoemulsion, moisturizing, transdermal

中图分类号:

TQ658

王兴婷, 施兆娟, 吴军, 袁传勋, 金日生. 油茶籽油-神经酰胺纳米乳液制备及研究[J]. 日用化学工业（中英文）, 2025, 55(6): 739-746.

Xingting Wang, Zhaojuan Shi, Jun Wu, Chuanxun Yuan, Risheng Jin. Preparation and study of Camellia oleifera seed oil-ceramide nanoemulsion[J]. China Surfactant Detergent & Cosmetics, 2025, 55(6): 739-746.

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试验号	A	B	C	粒径/nm
1	1	1	1	163.9
2	1	2	2	161.8
3	1	3	3	178.7
4	2	1	2	132.8
5	2	2	3	144.6
6	2	3	1	126.2
7	3	1	3	191.3
8	3	2	1	166.9
9	3	3	2	172.8
R₁	168.133	162.667	152.233
R₂	134.533	157.767	155.588
R₃	177.000	159.233	171.533
R	42.467	4.900	19.300

方差来源	离差平方和	自由度	均方	F值	P值	显著性
A	3 011.00	2	1 505.50	2 049.85	0.000 5	**
B	37.95	2	18.97	25.84	0.037 3	*
C	628.20	2	314.10	427.67	0.002 3	**
误差	1.47	2	0.734 4