生育酚纳米乳液的制备及性能研究

doi:10.3969/j.issn.2097-2806.2023.12.007

摘要/Abstract

摘要：

为提高α-生育酚（α-Toc）的稳定性和活性，利用超分子包合机理制备纳米乳液，得到了一种稳定性好、透皮效果佳、抗氧化性能优异的α-Toc纳米传递载体。考察了聚山梨醇酯（Tween）的种类、羟丙基-β-环糊精（HP-β-CD）的添加量和α-Toc溶液的添加量对纳米乳液粒径的影响，并借助傅里叶红外光谱、透射电子显微镜、纳米粒度分析仪、热重分析仪和Franz扩散池研究了α-Toc纳米乳液的包埋情况和性能评价。结果表明，所制备的α-Toc超分子纳米乳液的粒径小且分布均匀，在0 ℃和室温条件下具有良好的储藏稳定性。纳米乳液可以显著增强α-Toc的热稳定性，比未经过包裹的α-Toc具有更优异的抗氧化能力，纳米乳液在化妆品配方中可有效促进α-Toc的透皮吸收。

关键词: α-生育酚, 纳米乳液, 超分子, 性能研究

Abstract:

To improve the stability and activity of α-tocopherol （α-Toc）, a nanoemulsion was prepared by supramolecular inclusion method, which was a kind of nanocarrier for α-Toc with good stability, good transdermal effect and excellent anti-oxidation. The effects of the types of polysorbates （Tweens）, the amount of hydroxypropyl β-cyclodextrin （HP-β-CD） and the amount of α-Toc solution on the particle size of the nanoemulsion were investigated. The encapsulation condition and performance evaluation of α-Toc nanoemulsion were studied by Fourier infrared spectroscopy, transmission electron microscopy, nanoparticle size analysis, thermogravimetric analysis and Franz diffusion cell method. The results showed that the obtained α-Toc supramolecular nanoemulsion had small particle size and uniform distribution and had good storage stability both at 0 ℃ and room temperature. This nanoemulsion could significantly enhance the thermal stability of α-Toc, and it showed better antioxidant capacity than the nonencapsulated α-Toc. The nanoemulsion could also effectively promote the transdermal absorption of α-Toc in cosmetic formula. This work could provide research basis for the application of nanocarriers in the field of daily-use chemical industry.

Key words: α-tocopherol, nano-emulsion, supramolecule, performance study

中图分类号:

TQ658

蔡国强, 徐雯雯, 权琰, 潘卫, 张蕾, 何一波. 生育酚纳米乳液的制备及性能研究[J]. 日用化学工业（中英文）, 2023, 53(12): 1405-1411.

Guoqiang Cai, Wenwen Xu, Yan Quan, Wei Pan, Lei Zhang, Yibo He. Preparation and properties of α-tocopherol nanoemulsions[J]. China Surfactant Detergent & Cosmetics, 2023, 53(12): 1405-1411.

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组分名称	V/μL
组分名称	试剂1	试剂2	试剂3
待测样品	100	—	100
DPPH溶液	100	100	—
无水乙醇	—	100	100

试剂名称	分子式	HLB值	疏水基团	cmc值/（mmol/L）
T20	C₅₈H₁₁₄O₂₆	16.7	C12	0.049 9
T40	C₆₂H₁₂₂O₂₆	15.6	C16	0.033 3
T60	C₆₄H₁₂₆O₂₆	14.9	C18	0.016 7
T80	C₅₈H₁₂₄O₂₆	15.0	C18	0.015 0

组分名称	w/%
组分名称	含包封α-Toc的纳米乳液	含未包封的α-Toc纯品
去离子水	To 100	To 100
卡波姆	0.3	0.3
甘油	3	3
矿油	8	8
硬脂酸甘油酯，PEG-100硬脂酸酯	2	2
鲸蜡硬脂醇	1	1
α-Toc溶液	－	0.5
α-Toc纳米乳液	12.5	－
NaOH	0.08	0.08
苯氧乙醇	1.5	1.5