表皮葡萄球菌应用于化妆品的研究进展

doi:10.3969/j.issn.2097-2806.2025.01.011

摘要/Abstract

摘要：

皮肤微生态系统最大的特点是看似无序实则有条不紊的自我调节功能，为皮肤构筑了内生的免疫系统和外部的战略防线，表皮葡萄球菌是皮肤表面最常见的定殖菌之一，其具有极强的环境适应性和表型多样性，能长期存活于皮肤表面，同时表皮葡萄球菌在改善皮肤状态中具有重要功能如延缓皮肤衰老、保湿、抗紫外线、皮肤屏障修复等。文章介绍了表皮葡萄球菌在皮肤微生物中的角色，以及在功效护肤中的作用，并对表皮葡萄球菌在化妆品中的应用前景进行了分析展望，以期为功效护肤品的开发和应用提供有价值的参考。

关键词: 表皮葡萄球菌, 化妆品, 功效, 共生菌

Abstract:

The skin serves as a multifaceted barrier with numerous biological functions, and the presence of skin microbiota is integral to its overall functionality. Increasingly, the bacteria residing on the skin are acknowledged for their positive impact on human health. Staphylococcus epidermidis, the predominant colonizing bacteria on human skin, demonstrates remarkable resilience on normal skin surfaces due to its adept environmental adaptation, surface adhesion capabilities, and its role in maintaining cutaneous homeostasis and immune function. When skin health is compromised, Staphylococcus epidermidis demonstrates beneficial effects by exhibiting anti-inflammatory properties, promoting collagen synthesis, replenishing ceramide levels in the skin through sphingosphydase secretion, enhancing the tight junctions of keratinocytes to maintain skin barrier homeostasis, and interacting with host cells to preserve skin integrity. Furthermore, Staphylococcus epidermidis mitigates UV radiation damage by producing cytokines such as lipoteichoic acid or 6-HAP. Staphylococcus epidermidis and its metabolites have the potential to be utilized topically for skin improvement, either in their natural form or through genetic manipulation to enhance their beneficial properties. Cosmetic companies may explore the integration of these bacteria and their metabolites into skincare formulations to enhance skin health and preserve the skin’s microecological equilibrium, potentially offering personalized skincare solutions utilizing the consumers’ own Staphylococcus epidermidis.

Key words: Staphylococcus epidermidis, cosmetics, efficacy, symbiotic strains

中图分类号:

TQ658

文霞, 冯静, 刘静霞, 徐健, 陈相孩, 谢小保. 表皮葡萄球菌应用于化妆品的研究进展[J]. 日用化学工业（中英文）, 2025, 55(1): 89-97.

Xia Wen, Jing Feng, Jingxia Liu, Jian Xu, Xianghai Chen, Xiaobao Xie. Research progress of Staphylococcus epidermidis applied in cosmetics[J]. China Surfactant Detergent & Cosmetics, 2025, 55(1): 89-97.

图/表 2

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