地骨皮化学成分及其生物学功效研究进展

doi:10.3969/j.issn.1001-1803.2021.05.013

摘要/Abstract

摘要：

地骨皮为茄科植物枸杞的干燥根皮,是一类应用历史悠久的药食同源中药材,具有很高的生物学功效和药用价值。地骨皮含有多种生物碱类、有机酸及其酯类、苷类、甾醇类、香豆素类、蒽醌类、黄酮类等有效成分,药理活性丰富,同时也具有治疗皮肤损伤和美容护肤的功效。本研究重点讨论了地骨皮的来源与分布、有效化学成分、药理活性及作用机制、美容护肤作用及研究现状等,并对地骨皮作为天然功效原料在美容护肤和化妆品行业中的应用前景进行了展望。

关键词: 地骨皮, 化学成分, 药理作用, 美容护肤

Abstract:

Cortex Lycii, the dried root bark of Lycium barbarum L. and Lycium chinense Mill. which belongs to Lycium, is a kind of traditional Chinese medicine with a long history of medicine and food and has high biological efficacy and medicinal value. It contains a variety of ingredients, including alkaloids, organic acids, glycosides, sterols, coumarins, anthraquinones, flavonoids, etc. Not only has a wealth of pharmacological activity, but also has the treatment of skin damage and beauty skin care effect. This article aimed at reviewing the recent literatures on its origin and distribution, the effective chemical constituents, pharmacological activity and mechanism, skin care effect and research status of Cortex Lycii so as to look forward to the application prospect of Cortex Lycii as a natural functional raw material in skin care and cosmetics industry.

Key words: Cortex Lycii, chemical constituent, pharmacological activity, skin care

中图分类号:

TQ658

徐鹤然,赵乐,张晓娜,化璟琳,王敏,赵华. 地骨皮化学成分及其生物学功效研究进展[J]. 日用化学工业, 2021, 51(5): 450-456.

XU He-ran,ZHAO Le,ZHANG Xiao-na,HUA Jing-lin,WANG Min,ZHAO Hua. Research progress on the chemical constituents and biological effects of Cortex Lycii[J]. China Surfactant Detergent & Cosmetics, 2021, 51(5): 450-456.

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序号	化学式	成分名称	参考文献
1	C₂₁H₃₂O₁₀	dihydrophaseic acid 3′-O-β-D-glucopyranoside （二氢红花菜豆酸3'-O-β-D-吡喃葡萄糖苷）	[6]
2	C₁₈H₂₆O₁₀	phenethyl alcohol xylopyranosyl-（1→6）-glucopyranoside （苯乙醇吡喃木糖基-（1→6）-吡喃葡萄糖苷）	[6]
3	C₁₉H₂₈O₁₀	2-phenylethyl-α-Larabinopyranosyl-（1→6）-β-D-glucopyranoside （2-苯乙基-α-L-吡喃阿拉伯糖基-（1→6）-β-D-吡喃葡萄糖苷）	[6]
4	C₁₃H₁₈O₈	Tachioside （它乔糖苷）	[6]
5	C₁₅H₂₀O₁₀	glucosyringic acid （丁香酸葡萄糖苷）	[6]
6	C₁₆H₁₈O₉	isoscoploletin-β-D-glucoside （异东莨菪苷）	[6]
7	C₁₆H₁₈O₉	Scoploletin （东莨菪苷）	[5,6]
8	C₁₈H₂₆O₁₂	digupigan A （地骨皮苷甲）	[6]
9	C₂₈H₃₈O₁₃	（+）-lyoniresinol-3α-O-β-D-glucopyranoside [（+）-南烛木树脂酚-3α-O-β-D-吡喃葡萄糖苷]	[6]
10	C₂₈H₃₈O₁₃	（-）-lyoniresinol-3α-O-β-D-glucopyranoside [（-）-南烛木树脂酚-3α-O-β-D-吡喃葡萄糖苷]	[6]

序号	化学式	成分名称	参考文献
1	C₁₈H₂₁NO₄	dihydro-feruloyltyramine	[3]
2	C₁₇H₁₈NO₂	N-trans-cinnamoyltyramine （N-反式桂皮酸酰对羟基苯乙胺）	[3]
3	C₁₇H₁₇NO₄	N-trans-coumaroyloctopamine	[3]
4	C₁₈H₁₉NO₄	N-cis-feruloyltyramine （N-顺式-对羟基苯乙基阿魏酰胺）	[3]
5	C₁₈H₁₉NO₄	N-trans-feruloyltyramine （反式-N-阿魏酰酪胺）	[3]
6	C₁₇H₁₇NO₄	N-trans-caffeoyltyramine （反式-N-对羟基苯乙基咖啡酰胺）	[3]
7	C₁₈H₂₁NO₄	N-（4-Hydroxyphenethyl）-4-hydroxybenzeneacrylamide （反式-N-对羟基香豆酰酪胺）	[3]
8	C₁₇H₁₉NO₄	dihydro-N-caffeoyltyramine （二氢咖啡酰酪胺）	[3,19]
9	C₂₈H₄₂N₄O₆	kukoamine A （地骨皮甲素）	[19]
10	C₂₈H₄₂N₄O₆	kukoamine B （地骨皮乙素）	[19]
11	C₁₃H₁₈N₂O₃	cis-N-caffeoyl putrescine （顺式咖啡酰丁二胺）	[19]
12	C₁₃H₁₈N₂O₃	trans-N-caffeoyl putrescine （反式咖啡酰丁二胺）	[19]
13	C₁₄H₂₀N₂O₃	N-isoferuloyl putrescine （异阿魏酰丁二胺）	[19]
14	C₁₈H₁₉NO₅	trans-N-faruloyloctopamine （反式阿魏酰章胺）	[19]
15	C₁₇H₁₇NO₄	trans-N-caffeoyltyramine （反式咖啡酰酪胺）	[19]
16	C₁₇H₁₇NO₄	cis-N-caffeoyltyramine （顺式咖啡酰酪胺）	[19]
17	C₁₇H₁₇NO₃	N-coumaroyl tyramine （香豆酰酪胺）	[19]