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日用化学工业 ›› 2017, Vol. 47 ›› Issue (10): 573-577.doi: 10.13218/j.cnki.csdc.2017.10.008

• 开发与应用 • 上一篇    下一篇

不同剂型四氢姜黄素皮肤渗透性的研究

叶凤, 肖伟莉, 文国锦, 杨兴东, 王雪梅   

  1. 安徽大学 化学化工学院,安徽 合肥 230601
  • 收稿日期:2017-07-23 发布日期:2019-03-21
  • 通讯作者: 王雪梅,副教授,硕士生导师,E-mail:wangxm929@139.com。
  • 作者简介:叶 凤(1993-),女,安徽安庆人,硕士研究生,E-mail:18755108975@163.com。
  • 基金资助:
    安徽省绿色高分子材料重点实验室资助项目(kf2012006)

Study on the cutaneous permeation of tetrahydrocurcumin in various formulations

YE Feng, XIAO Wei-li, WEN Guo-jin, YANG Xing-dong, WANG Xue-mei   

  1. College of Chemistry and Chemical Engineering,Anhui University,Hefei,Anhui 230601,China
  • Received:2017-07-23 Published:2019-03-21

摘要: 通过体外经皮实验研究四氢姜黄素(THC)的渗透性,采用高效液相色谱法测定其在50%乙醇水溶液、乳液、固体脂质纳米粒3种剂型中以及分别加入氮酮后的累积透过率与滞留率。结果表明,累积透过率和滞留率均随着渗透时间的延长而增加;THC在50%乙醇水溶液中渗透性最强,在乳液中最弱;氮酮对50%乙醇水溶液中THC的促渗作用最明显,对乳液中THC的促渗作用最不明显;与未加氮酮相比,相同的渗透时间内,累积透过率均有所增加,滞留率没有明显变化。

关键词: 化妆品功效成分, 四氢姜黄素, 高效液相色谱法, 累积透过率, 滞留率

Abstract: The permeability of tetrahydrocurcumin (THC) was studied through experiments in vitro percutaneous.The cumulative permeation rates (CPRs) and retention rates (RRs) in 50% aqueous ethanol,emulsion,solid lipid nanoparticles,and in which before and after adding azone were all determined by high performance liquid chromatography (HPLC).Results show that the CPRs and RRs of THC increase with permeation time.Its permeability is the strongest in 50% aqueous ethanol,and the weakest in emulsion.After adding azone,the enhancing permeation effect is the most remarkable in 50% aqueous ethanol and the least remarkable in emulsion.Comparing with no azone at the same permeation time,the CPRs in all formulations are improved significantly,and the RRs show no significant change.

Key words: cosmetic ingredient, tetrahydrocurcumin, HPLC, cumulative permeation rate, retention rate

中图分类号: 

  • TQ658