海藻糖脂在清洁体系中的泡沫和温和性研究

doi:10.3969/j.issn.2097-2806.2025.09.009

摘要/Abstract

摘要：

本研究旨在评估海藻糖脂在清洁产品中的泡沫性能与温和性，并与传统的非离子表面活性剂烷基糖苷（APG）进行对比。通过对比单一表面活性剂和表面活性剂组合的不同体系，结果表明，海藻糖脂在降低表面张力、提高泡沫性能和改善温和性方面具有明显优势。特别是在表面活性剂组合物中加入海藻糖脂后，不仅表面张力得到有效降低，泡沫性能和皮肤温和性均有显著提升。此外，海藻糖脂相比APG展现了更好的皮肤温和性和较低的细胞毒性。结合体外和人体试验数据，本研究进一步验证了海藻糖脂在清洁产品中的应用潜力，证明其作为替代传统表面活性剂的可行性，尤其在提高产品温和性的同时保证了泡沫性能。

关键词: 海藻糖脂, 泡沫, 温和性, 温和性比色指数, zeta电位, 人体斑贴试验

Abstract:

The paper investigates the foaming and mildness properties of trehalolipids surfactant in rinse-off formulations, comparing it with the traditional nonionic surfactant alkyl-polyglycolide （APG）. Both single surfactant and their surfactant complexes are evaluated. And the results show that trehalolipids have significant advantages in reducing surface tension, improving foam performance, and enhancing mildness. For mildness evaluation, multiple methods are employed in the study, including in vitro cell toxicity, inflammatory markers, colorimetric index of mildness CIM, and in vivo method of human skin patch test. The results show that the addition of trehalolipids increases IC50 and reduces the release of inflammatory markers of the binary surfactant system. However, the incorporation of trehalolipids has some negative effects on the skin’s lipid barrier function. Skin patch test results indicate that the addition of trehalolipids improves the mildness of surfactant system, particularly in sulfate-free system. Overall, trehalolipids, as nonionic surfactants, presents great potential to replace traditional surfactants in rinse off formulations with enhanced mildness and foam performance.

Key words: trehalolipids, foam, mildness, colorimetric index of mildness CIM, zeta potential, skin patch test

中图分类号:

TQ423

陈梅, 吴瑶瑶, 夏丹丹, 常晓维, 苏桂珍, 柳晨. 海藻糖脂在清洁体系中的泡沫和温和性研究[J]. 日用化学工业（中英文）, 2025, 55(9): 1153-1162.

Mei Chen, Yaoyao Wu, Dandan Xia, Xiaowei Chang, Guizhen Su, Chen Liu. Foam and mildness study of trehalolipid surfactant in rinse off formulations[J]. China Surfactant Detergent & Cosmetics, 2025, 55(9): 1153-1162.

图/表 12

参考文献 33

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System	Composition	mass ratio	No.
SLES system	SLES∶CAPB	9∶9	S1
	SLES∶CAPB∶DG	6∶6∶6	S2
	SLES∶CAPB∶THL	6∶6∶6	S3
SMCT system	SMCT∶CAPB	9∶9	S4
	SMCT∶CAPB∶DG	6∶6∶6	S5
	SMCT∶CAPB∶THL	6∶6∶6	S6

Samples	Irritation Score （IS）
Samples	0.5 h	24 h	48 h	Total Score	Total Irritation Score （TIS）
S1	7^*	0	0	7^*	0.21^*
S2	6^*	0	0	6^*	0.18^*
S3	6^*	0	0	6^*	0.18^*
S4	5^*	2	0	7^*	0.21^*
S5	8^*	0	0	8^*	0.24^*
S6	5^*	0	0	5^*	0.15^*
Water	0	0	0	0	0