Fe3O4纳米粒子的制备及载药释放性能研究

doi:10.3969/j.issn.2097-2806.2024.06.008

摘要/Abstract

摘要：

采用改进的Hummers法获得氧化石墨烯（GO），通过共沉淀法制备了GO与磁性Fe₃O₄纳米粒子结合的GO/Fe₃O₄复合材料，分析了复合材料的晶体结构、微观形貌、磁化性能和载药性能，研究结果表明：GO/Fe₃O₄复合材料具有较高的结晶度，GO掺杂改善了Fe₃O₄颗粒的均匀度，晶粒尺寸为13~15 nm。GO/Fe₃O₄复合材料表现出超顺磁性，饱和磁化强度有轻微降低。利用GO/Fe₃O₄负载阿霉素（DOX）研究了载药释放性能，GO/Fe₃O₄/DOX包合物的DOX包封率均值为62.24%，具有较高的包封率，药物释放具有一定的pH依赖性，在pH=7.4时，GO/Fe₃O₄的累计释放率在75 h达到73.3%，摄入试验测试表明GO/Fe₃O₄载体具有一定的靶向性，在生物医学领域有广阔的应用前景。

关键词: 氧化石墨烯, Fe₃O₄, 磁性材料, 共沉淀法, 阿霉素, 药物载体

Abstract:

Graphene oxide （GO） was obtained by the improved Hummers method. The GO/Fe₃O₄ composite, in which GO was combined with magnetic Fe₃O₄ nanoparticles, was prepared by co-precipitation method. The crystalline structure, microscopic morphology, magnetic properties and drug loading of the composite were analyzed. The results showed that: The GO/Fe₃O₄ composite had high crystallinity; GO doping improved the uniformity of Fe₃O₄ particles, and the grain size of GO/Fe₃O₄ composite was 13-15 nm. The GO/Fe₃O₄ composite exhibited superparamagnetic properties with a slight decrease in saturation magnetization. The drug-release properties were studied by using GO/Fe₃O₄ composite to load doxorubicin （DOX）. The average encapsulation efficiency of GO/Fe₃O₄/DOX inclusion complex was 62.24%, which was quite high. The drug release showed pH dependence. When the pH was 7.4, the cumulative release rate reached 73.3% in 75 h. The cellular uptake test showed that the GO/Fe₃O₄ carrier had certain targeting properties and could be used as a good new drug carrier.

Key words: graphene oxide, Fe₃O₄, magnetic material, co-precipitation method, doxorubicin, drug carrier

中图分类号:

O611

高蓉, 石森林. Fe₃O₄纳米粒子的制备及载药释放性能研究[J]. 日用化学工业（中英文）, 2024, 54(6): 677-682.

Rong Gao, Senlin Shi. Preparation of Fe₃O₄ nanoparticles and its drug-loading and drug-release properties[J]. China Surfactant Detergent & Cosmetics, 2024, 54(6): 677-682.

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包合物中DOX的量/mg	包封率/%	平均值/%
0.284 2	52.64	62.24±3.87
0.258 3	73.11
0.264 3	57.15
0.374 7	62.98
0.337 2	65.31

Fe₃O₄纳米粒子的制备及载药释放性能研究

Preparation of Fe₃O₄ nanoparticles and its drug-loading and drug-release properties

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