药用层孔菌发酵液控油及收缩毛孔机理及功效研究

doi:10.3969/j.issn.2097-2806.2024.05.010

Abstract

Abstract:

The fermentation broth of Fomes officinalis was obtained by two-way fermentation of Fomes officinalis and Lactococcus lactis, and the contents of active components in the fermentation broth and aqueous extract were detected. The effects of Fomes officinalis fermentation broth on oil control and pore contraction were studied from the aspects of molecule, cell, animal and human body. The fermentation of Fomes officinalis has higher content of active components, can reduce the production of ABTS free radicals, inhibit the expression of inflammatory factors TNF-α and IL-6, regulate the activity of 5α reductase, reduce skin oil secretion, promote the expression of type Ⅰ collagen （COL-Ⅰ）, inhibit the expression of metalloproteinase-1 （MMP-1）, have the tendency of shrinking pores. It has the potential to become a cosmetic raw material with the effect of oil control and pore refining.

Key words: Fomes officinalis, raw material of cosmetics, fermentation technology, oil control effect, shrinking pores

CLC Number:

TQ658

Yang Song, Yongbo Lv, Hankun Ren, Jiaolong Peng. Study on the mechanism and efficacy of controlling oil and shrinking pores in fermentation broth of Fomes officinalis[J].China Surfactant Detergent & Cosmetics, 2024, 54(5): 566-573.

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References 17

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添加试剂	受试样品	阳性物	50%乙醇	ABTS溶液
样品组	+	-	-	+
阳性对照组	-	+	-	+
阴性对照组	-	-	+	+
空白对照组	+	-	+	-

物质名称	加入量/μL	终浓度/（μmol/L）
5α-还原酶液	10	—
T	5	25
NADPH	10	100
待测药物	5
PBS	220

	总多糖含量/（mg/mL）	总甾醇含量/（mg/g）	总氨基酸含量/（mg/mL）
药用层孔菌发酵液	11.4	0.94	2.561
药用层孔菌水提液	1.49	0.32	0.251

Study on the mechanism and efficacy of controlling oil and shrinking pores in fermentation broth of Fomes officinalis

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