聚甘油酯类乳化剂疏水基对液晶形成的影响及其促进机制研究

doi:10.3969/j.issn.2097-2806.2025.12.007

Abstract

Abstract:

In this paper, by investigating the binary phase behavior, surface tension, saturated adsorption capacity and critical packing parameters of polyglycerol ester emulsifiers with different numbers of hydrophobic chains, the influence of hydrophobic groups on the formation of layered liquid crystals of polyglycerol ester emulsifiers was studied. At the same time, the promotion mechanism of critical packing parameters was studied by compounding fatty alcohols in different proportions. The results show that polyglycerol ester emulsifier molecules spontaneously form layered liquid crystal structure, and with the enhancement of hydrophobic interaction, emulsifier molecules are enriched at the gas-liquid interface, CPP increases, the appearance of liquid crystal regions gradually expands to low concentration and high temperature regions, forming crystalline phases in a wider concentration region. The hydrophilic head groups of C18 alcohol and emulsifier molecules form a closer regular arrangement through hydrogen bonding, and the hydrophobic tail chain interact through hydrophobic interaction, which reduces the minimum cross-sectional area A₀ of emulsifier molecules and more effectively improves the mixed micelle system. When the concentration is higher than 8%, the critical stacking parameter CPP increases. The hydrophobic interaction between emulsifier-C18 alcohol molecules is enhanced, the number and regularity of liquid crystal structures are significantly increased, which is conducive to the formation of liquid crystal structures.

Key words: polyglycerol ester emulsifier, self-assembly, liquid crystals, critical packing parameter

CLC Number:

TQ423

Qianjie Zhang, Zhenzhi Zhao, Shanshan Wang, Jie Gu, Zhi Lv, Wanping Zhang. Effect of hydrophobic groups of polyglycerol ester emulsifiers on liquid crystal formation and its promotion mechanism[J].China Surfactant Detergent & Cosmetics, 2025, 55(12): 1552-1559.

Figures/Tables 11

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References 27

[1]	冯尚华, 王红霞, 张高勇, 等. 表面活性剂溶致液晶的流变学性质[J]. 化学进展, 2004, 16 (5) : 687-695.
[2]	张毅, 陈微, 韩艳琪, 等. 层状液晶乳化技术包载天然活性物质用于功能化妆品的研究进展[J]. 药学学报, 2024: 1-24.
[3]	周康夫, 晏佳怡, 尚亚卓. 新型乳化体系及其在化妆品中的应用(I)——液晶乳化体系[J]. 日用化学工业(中英文), 2023, 53 (9) : 1008-1017.
[4]	Zhang Wanping, Liu Lingyan. Study on the formation and properties of liquid crystal emulsion in cosmetic[J]. Journal of Cosmetics, Dermatological Sciences and Applications, 2013, 3 (2) : 139-144. doi: 10.4236/jcdsa.2013.32022
[5]	蔡国强, 陈莹莹, 潘卫, 等. 聚甘油酯类乳化剂PolyAquol-2W形成液晶结构的研究[J]. 香料香精化妆品, 2023 (5) : 25-29, 126.
[6]	Ghosh S, Ray A, Pramanik N. Self-assembly of surfactants: An overview on general aspects of amphiphiles[J]. Biophysical Chemistry, 2020, 265: 106429. doi: 10.1016/j.bpc.2020.106429
[7]	Sharma V K, Mitra S, Mukhopadhyay R. Dynamic landscape in self-assembled surfactant aggregates[J]. Langmuir, 2019, 35 (44) : 14151-14172. doi: 10.1021/acs.langmuir.8b03596 pmid: 30730752
[8]	Antonietti M, Förster S. Vesicles and liposomes: A self-assembly principle beyond lipids[J]. Advanced Materials, 2003, 15 (16) : 1323-1333. doi: 10.1002/adma.v15:16
[9]	John Mitchell D, W Ninham Barry. Micelles, vesicles and microemulsions[J]. Journal of the Chemical Society, Faraday Transactions 2: Molecular and Chemical Physics, 1981, 77 (4) : 601-629. doi: 10.1039/f29817700601
[10]	Guo Chenyu, Wang Jun, Cao Fengliang, et al. Lyotropic liquid crystal systems in drug delivery[J]. Drug Discovery Today, 2010, 15(23/24): 1032-1040. doi: 10.1016/j.drudis.2010.09.006
[11]	Kobierski J, Wnętrzak A, Chachaj-Brekiesz A, et al. Predicting the packing parameter for lipids in monolayers with the use of molecular dynamics[J]. Colloids and Surfaces B: Biointerfaces, 2022, 211: 112298. doi: 10.1016/j.colsurfb.2021.112298
[12]	Wu Na, Ye Zhicheng, Zhou Kangfu, et al. Construction and properties of O/W liquid crystal nanoemulsion[J]. Langmuir, 2024, 40 (14) : 7723-7732. doi: 10.1021/acs.langmuir.4c00424
[13]	Teeranachaideekul V, Soontaranon S, Sukhasem S, et al. Influence of the emulsifier on nanostructure and clinical application of liquid crystalline emulsions[J]. Scientific Reports, 2023, 13 (1) : 4185. doi: 10.1038/s41598-023-31329-w pmid: 36918671
[14]	Hu Jiajie, Ni Zhuoyao, Zhu Hanglin, et al. A novel drug delivery system: Drug crystallization encapsulated liquid crystal emulsion[J]. International Journal of Pharmaceutics, 2021, 607: 121007. doi: 10.1016/j.ijpharm.2021.121007
[15]	刘慧民, 马骁原, 赵永红. 液晶乳液制备的影响因素及其在化妆品中的应用[J]. 日用化学工业(中英文), 2022, 52 (7) : 762-769.
[16]	Zhao Hongxia, Yang Yong, Shu Xin, et al. Micelle conformation of sodium alkyl sulfate surfactants with different hydrophobic chain length: A molecular dynamics study[J]. Computational Materials Science, 2023, 229: 112452. doi: 10.1016/j.commatsci.2023.112452
[17]	贾兵. 液晶结构乳状液形成的规律性研究[D]. 上海: 上海应用技术大学, 2018.
[18]	Ahmadi D, Mahmoudi N, Heenan R K, et al. The Influence of co-surfactants on lamellar liquid crystal structures formed in creams[J]. Pharmaceutics, 2020, 12 (9) : 864. doi: 10.3390/pharmaceutics12090864
[19]	Su Chunxia, De Meulenaer B, Van Der Meeren P. Analytics and applications of polyglycerol polyricinoleate (PGPR): Current research progress[J]. Comprehensive Reviews in Food Science and Food Safety, 2023, 22 (6) : 4282-4301. doi: 10.1111/crf3.v22.6
[20]	Vereroudakis E, Vlassopoulos D. Tunable dynamic properties of hydrogen-bonded supramolecular assemblies in solution[J]. Progress in Polymer Science, 2021, 112: 101321. doi: 10.1016/j.progpolymsci.2020.101321
[21]	Kshevetskiy M S, Shchekin A K. The aggregation work and shape of molecular aggregates upon the transition from spherical to globular and cylindrical micelles[J]. Colloid Journal, 2005, 67 (3) : 324-336. doi: 10.1007/s10595-005-0100-x
[22]	Yada S, Yoshioka Y, Ohno M, et al. Adsorption and aggregation properties of homogeneous polyoxyethylene alkyl ether-and ester-type nonionic surfactants with multi-branched double chains[J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 648: 129247. doi: 10.1016/j.colsurfa.2022.129247
[23]	Chandler D. Interfaces and the driving force of hydrophobic assembly[J]. Nature, 2005, 437 (7059) : 640-647. doi: 10.1038/nature04162
[24]	Vereroudakis E, Vlassopoulos D. Tunable dynamic properties of hydrogen-bonded supramolecular assemblies in solution[J]. Progress in Polymer Science, 2021, 112: 101321. doi: 10.1016/j.progpolymsci.2020.101321
[25]	Song Zhaohua, Xin Xia, Shen Jinglin, et al. Manipulation of lyotropic liquid crystal behavior of ionic liquid-type imidazolium surfactant by amino acids[J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2017, 518: 7-14. doi: 10.1016/j.colsurfa.2017.01.004
[26]	Yue Xiu, Fan Xiaoyun, Li Qiantang, et al. Aggregation behaviors of alkyl ether carboxylate surfactants in water[J]. Journal of Molecular Liquids, 2017, 227: 161-167. doi: 10.1016/j.molliq.2016.12.010
[27]	Feng Bei, Shang Yazhao, Li Chengliang, et al. Study on the influence of oils on the formation of liquid crystal structure of hydrogenated lecithin system[J]. Liquid Crystals, 2024: 1-14.

	助/乳比	cmc/（mol/L）	γ_cmc/（mN/m）	Γ_∞/（mol/m²）	CPP
聚甘油-10硬脂酸酯	单体系	1.00×10^-5	38.65±1.67	1.03×10^-6	0.131
聚甘油-10硬脂酸酯	1∶1	8.00×10^-5	33.20±1.33	2.30×10^-6	0.293
聚甘油-10二硬脂酸酯	单体系	2.10×10^-5	42.13±1.53	1.48×10^-6	0.189
聚甘油-10三硬脂酸酯	单体系	2.15×10^-5	35.11±1.29	2.09×10^-6	0.267

Effect of hydrophobic groups of polyglycerol ester emulsifiers on liquid crystal formation and its promotion mechanism

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