EGCG柔性脂质体的制备及其透皮性能研究

doi:10.3969/j.issn.1001-1803.2021.05.003

Abstract

Abstract:

EGCG flexible liposomes were prepared by modifying the EGCG liposomes with edge activators. The effects of the type and dosage of edge activators on the particle size, encapsulation rate and yield of EGCG flexible liposomes were investigated. The results showed that when Tween 80 was used as the edge activator and the dosage was 50% （the mass ratio to lecithin）, the particle size, encapsulation rate and yield were better, which were （77.8±1.40） nm, 85.18%±1.22% and 96.77%±1.47%, respectively. The transdermal experiment showed that the EGCG flexible liposomes exhibited better transdermal effect than the liposomes. The transdermal content of EGCG flexible liposomes was 21.13 μg/cm² after 24 h, which was significantly higher than EGCG liposomes. It was consistent with the results of fluorescence labeling experiment. Storage stability experiments showed that, compared with EGCG liposomes, the EGCG flexible liposomes were more stable, and the retention rate was up to 88.24% after being stored in the dark at 4 ℃ for 60 days.

Key words: EGCG, flexible liposome, skin penetration, stability

CLC Number:

TQ658

CHEN Feng-feng,CAO Zhen-da,LIANG Rong. Study on the preparation and transdermal performance of EGCG flexible liposome[J].China Surfactant Detergent & Cosmetics, 2021, 51(5): 390-395.

Figures/Tables 7

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Study on the preparation and transdermal performance of EGCG flexible liposome

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