几种儿童牙膏体外细胞毒性研究

doi:10.13218/j.cnki.csdc.2015.05.010

Abstract

Abstract: In vitro cultivated human oral mucosal fibroblasts were used to determine the relative growth rate (RGR) and cytotoxicity grade of extract of several kinds of common children toothpaste and swallow-able children toothpaste via MTT method,and compared with that of adult toothpaste.It reflected the influence of the toothpaste to oral mucosa.Results showed that,the cytotoxicity of swallow-able children toothpaste and common children toothpaste is relatively lower than that of adult toothpaste.There are significant difference between the adult toothpaste and children toothpastes on cell growth rate (P<0.05).Cytotoxicity of adult toothpaste is relatively higher,and may cause irritation to the oral mucosa of children.

Key words: toothpaste for children, swallow-able toothpaste, oral mucosa cells, cytotoxicity

CLC Number:

TQ658.4+1

ZHU Zhou-hai, LIU Feng-zhi, HUANG Hai-tao, ZHANG Tao, MI Qi-li, GUAN Ying, YAO Jian-hua. In vitro cytotoxicity study on several kinds of toothpaste for children[J].China Surfactant Detergent & Cosmetics, 2015, 45(5): 282-284.

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In vitro cytotoxicity study on several kinds of toothpaste for children

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