一种基于胆固醇衍生物的两亲分子的合成及其聚集行为

doi:10.13218/j.cnki.csdc.2016.05.001

Abstract

Abstract: A new kind of surfactant composed of amphiphilic molecules,potassium salt of N-cholesterol formyl glycylglycine (Chol-GG-K) employing cholesterol as the hydrophobic moiety and glycylglycine as the hydrophilic group,was synthesized and characterized.The aggregation behavior of the product in water was investigated by transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM).Results indicated that poly dispersive vesicles formed in Chol-GG-K aqueous solution.Besides the van der Waals interaction of cholesterol that forms strong hydrophobic effect and aggregation capacity,the hydrogen bonding of the hydrophilic group is also a driving force for the aggregation.

Key words: amphiphilic molecules, cholesterol, aggregation behavior, vesicle, van der Waals interaction

CLC Number:

TQ423

HAO Shan-shan,ZHAO Li,XU Bao-cai. Synthesis of cholesterol derivative based amphiphilic molecules and their aggregation behavior[J].China Surfactant Detergent & Cosmetics, 2016, 46(5): 243-246.

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Synthesis of cholesterol derivative based amphiphilic molecules and their aggregation behavior

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