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2020年, 第50卷, 第12期　刊出日期：2020-12-22 上一期    下一期

基础研究

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共轭亚油酸水相聚合制备荧光纳米点的性质研究 Investigation on fluorescence characteristics of nanodots prepared by aqueous polymerization of conjugated linoleic acid 曹崇梅,樊晔,方云,夏咏梅 2020 (12):  815-820.  doi: 10.3969/j.issn.1001-1803.2020.12.001 摘要 ( 324 )   HTML ( 79 )   PDF(1447KB) ( 295 )   以一种天然不饱和脂肪酸共轭亚油酸（CLA）为碳源,引发其共轭双键聚合制得平均粒径为16 nm且具有蓝绿光发射的荧光纳米点（FNDs）。与其他生物质碳源制备碳点（CDs）的报道相比,该法以生物质小分子的常温水相聚合反应控制FNDs形成,低温节能,安全性高。由于该法以共轭双键的加成聚合反应为主,因此反应可控性和产物粒径可控性强。实验结果显示该FNDs最佳激发波长为320 nm;随FNDs内部聚合度增大该FNDs由激发依赖性转变为部分激发依赖性;随碳源浓度增大出现自吸收性。该研究对利用天然油脂原料制备纳米材料有理论和实用意义,而碳源绿色化、产物生物相容性及水相聚合反应环境友好性使该FNDs具有在药物和日用化学品中应用的前景。 Bluish-green light-emitting fluorescence nanodots （FNDs） were prepared by aqueous polymerization in virtue of conjugated double bonds of conjugated linoleic acid （CLA）, indicative of an average particle size of 16 nm. The formation of the FNDs was conducted by polymerizing biomass small molecules in water at relatively low temperature, which was energy saving and safe compared with the reports of carbon dots （CDs） from other biomass carbon sources. This method was mainly based on the addition polymerization of the conjugated double bonds, indicative of good controllability for both reaction and particle size. The experimental results showed that, the FNDs had the optimal excitation wavelength of 320 nm; the excitation dependence would shift to partial excitation dependence when the degree of polymerization was increased; self-absorption had appeared as the concentration of carbon source was increased. Therefore, the study had theoretical and practical significance for the preparation of nanomaterials from natural fats and oils. The FNDs showed the potential of application in drugs and daily chemicals due to the green carbon source, the biocompatible product and the eco-friendly aqueous polymerization. 数据和表 | 参考文献 | 相关文章 | 计量指标

科技讲座

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两亲聚合物设计合成及其增效体系研究（XII）——提高采收率 Study on the design and synthesis of amphiphilic polymers and their synergistic systems （XII） Enhanced oil recovery 康万利,贾茹雪,杨红斌,朱彤宇,李哲,Bauyrzhan Sarsenbekuly 2020 (12):  821-828.  doi: 10.3969/j.issn.1001-1803.2020.12.002 摘要 ( 255 )   HTML ( 7 )   PDF(1258KB) ( 366 )   两亲聚合物以其良好的增黏能力和乳化性能,在油田提高采收率领域逐步开展应用。本文首先从提高波及系数和洗油效率两方面总结了两亲聚合物的提高采收率机理,其次从油藏条件和两亲聚合物注入参数两方面分析了两亲聚合物提高采收率效果的影响因素,最后探讨了三大类两亲聚合物增效体系的提高采收率潜力。研究成果可为矿场两亲聚合物提高采收率效果评价预测以及矿场方案设计提供指导。 Amphiphilic polymers, with their excellent thickening and emulsifying properties, have been gradually applied in the field of enhanced oil recovery. The mechanism of enhanced oil recovery by amphiphilic polymers was summarized from the aspects of enhancing sweep efficiency and displacement efficiency. The recovery efficiency of amphiphilic polymers under different injection modes was investigated, including injection slug size and injection timing. Finally, the potential of enhanced oil recovery for the three types of synergistic systems was discussed. The research results could provide guidance for the evaluation and prediction of the recovery efficiency of amphiphilic polymers in the oilfield. 数据和表 | 参考文献 | 相关文章 | 计量指标

开发与应用

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烷基二苯醚双磺酸钠的性能研究 Study of the performance of sodium alkyl diphenyl ether disulfonates 曹圣悌,焦提留,霍月青,刘晓臣,牛金平 2020 (12):  829-832.  doi: 10.3969/j.issn.1001-1803.2020.12.003 摘要 ( 422 )   HTML ( 14 )   PDF(1657KB) ( 308 )   测定了双辛烷基二苯醚双磺酸钠（C8-DADS）和单十六烷基二苯醚双磺酸钠（C16-MADS）的耐酸性、耐碱性、热稳定性、平衡表面张力、与阳离子表面活性剂十二烷基三甲基氯化铵（DTAC）复配体系稳定性及界面张力。结果表明：C16-MADS的耐酸性、耐碱性、高温稳定性优于C8-DADS;C16-MADS临界胶束浓度（cmc）低于C8-DADS,C16-MADS cmc处的表面张力高于C8-DADS;C16-MADS/DTAC复配体系稳定性优于C8-DADS/DTAC;C8-DADS/DTAC复配体系质量比为8:2时平衡界面张力最低,可达到10-3mN/m数量级。 The acid resistance, alkali resistance, thermal stability and surface tension of sodium dioctyl diphenyl ether disulfonate （C8-DADS） and sodium monohexadecyl diphenyl ether disulfonate （C16-MADS） were studied. The solution stability and interfacial tension of the system of C8-DADS （or C16-MADS） mixed with dodecyltrimethylammonium chloride （DTAC） were investigated. The results were as follows: the H2SO4 resistance, NaOH resistance and thermal stability of C16-MADS were better than that of C8-DADS; the critical micelle concentration （cmc） of C16-MADS was lower than that of C8-DADS, and the surface tension at cmc of C8-DADS was lower than that of C16-MADS; the solution stability of C16-MADS/DTAC was higher than that of C8-DADS/DTAC; the interfacial tension of the system with m（C8-DADS）:m（DTAC） of 8:2 was very low and could reach the order of 10-3mN/m. 数据和表 | 参考文献 | 相关文章 | 计量指标

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双酚A酚胺树脂嵌段聚醚的合成及破乳性能研究 Study on the synthesis and demulsification of phenol-amine resin block polyether based on bisphenol A 曾浩见,常振,冀文雄,铁磊磊,李翔 2020 (12):  833-841.  doi: 10.3969/j.issn.1001-1803.2020.12.004 摘要 ( 386 )   HTML ( 9 )   PDF(1606KB) ( 807 )   以双酚A和多乙烯多胺为原料,制备了酚胺树脂BPA。以BPA为起始剂,固定PO/EO质量比为3:1,合成了8种不同BPA/PO质量比的二嵌段聚醚破乳剂。结果表明,当BPA/PO质量比为1:99时,二嵌段聚醚破乳剂的脱水速率和脱水量均最大。当固定BPA/PO质量比为1:99时,合成了不同PO/EO质量比的二嵌段聚醚破乳剂,以及不同嵌段方式的多嵌段聚醚破乳剂。采用瓶试法,在50 ℃,破乳剂质量浓度为50 mg/L条件下,对上述原油破乳剂的破乳性能进行了评价。结果表明,当PO/EO质量比等于1.5:1时,BPA99系列破乳剂的破乳性能最好。随着EO含量的增加,破乳剂分子的亲水性逐渐增加,在油水两相会有合适的分配系数,这有利于水滴的聚并和油/水界面膜强度的降低。动态界面张力曲线说明上述破乳剂分子具有较强的扩散能力。随着EO含量的增加,破乳剂分子的界面活性逐渐增强,置换界面活性物质的能力更强。对于不同嵌段顺序的聚醚破乳剂,BPA-PO-EO结构的BPA9915和BPA9910具有较好的破乳性能,而具有BPA-EO-PO结构的BPA9915R和BPA9910R的破乳性能最差。与二嵌段破乳剂BPA9915和BPA9910相比,三嵌段和四嵌段破乳剂分子的脱水速率明显低,最终的脱水率也更低。四嵌段聚醚尾端的EO含量越高,破乳性能越好。与现场在用破乳剂TS-P100A和DM-4002相比,BPA9915的破乳性能更好。 Phenol-amine resin （BPA） was synthesized from bisphenol A and polyethylene polyamine. At the PO/EO mass ratio of 3:1, eight kinds of bi-block polyethers with different BPA/PO mass ratios were synthesized. The results showed that the drainage rate and drainage volume for the bi-block polyether with the BPA/PO mass ratio of 1:99 were higher than others. Then, at the BPA/PO mass ratio of 1:99, bi-block polyethers with different PO/EO mass ratios and multi-block polyethers with different PO/EO orders were synthesized. The properties of these oil demulsifiers were evaluated using bottle-testing method at 50 ℃ with the demulsifier mass concentration of 50 mg/L. The results showed that the demulsifying properties of BPA99 demulsifiers reached a maximum at the PO/EO mass ratio of 1.5:1. With the increase of EO content, the hydrophilicity of the demulsifier increased gradually, and thus these molecules would have an appropriate partition coefficient between the oil and aqueous phases. This would benefit the coalescence of water droplets and the decrease of strength of oil-water interfacial film. Dynamic interfacial tension curves indicated that these demulsifiers exhibited rapid interfacial diffusion. With the increase of EO content, the interfacial activity and the ability of interfacial displacement of the demulsifier increased gradually. For the multi-block polyethers with different PO/EO orders, the demulsifying properties of BPA9915 and BPA9910 with the structure of BPA-PO-EO were higher than others. The demulsifiers with the structure of BPA-EO-PO had harmful demulsifying properties. Compared with the bi-block polyethers （BPA9915 and BPA9910）, the tri-block polyethers and tetra-block polyethers showed a low drainage volume and a slow drainage rate. When the EO content in the terminal block was increased （the total number of EO units was fixed）, the demulsifying properties of the tetra-block polyether became excellent. Compared with TS-P100A and DM-4002 used in the oilfield, BPA9915 showed better demulsifying properties. 数据和表 | 参考文献 | 相关文章 | 计量指标

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基于十四烷基二乙烯三胺的CO2响应性Pickering乳液的稳定性能研究 A study on the stability of CO2-triggered Pickering emulsion based on tetradecyldiethylenetriamine 冯晓君,张鹏,李蕊蕊,赖璐 2020 (12):  842-847.  doi: 10.3969/j.issn.1001-1803.2020.12.005 摘要 ( 317 )   HTML ( 10 )   PDF(2169KB) ( 248 )   以正癸烷为油相,纳米SiO2和十四烷基二乙烯三胺（C14DETA）为乳化剂,制备了CO2响应性O/W型Pickering乳状液。交替通入CO2和N2,该乳状液在25 ℃下实现了“开（稳定）”和“关（不稳定）”之间的多次转换。通入CO2时,C14DETA质子化成C14DETA-CO2,通过静电作用吸附至带负电的SiO2颗粒表面,产生原位疏水作用,使其转变为表面活性颗粒,从而稳定乳状液;通入N2时,C14DETA-CO2去质子化为C14DETA,原位疏水作用解除,导致乳状液完全破乳。通过研究确定乳化的较佳条件：油水体积比为1:1,纳米SiO2的质量分数为0.05%,C14DETA-CO2浓度为2×10-3 mol/L。与C14DETA稳定的乳状液对比,Pickering乳状液中表面活性剂使用量更少,稳定性更强。 The CO2-triggered O/W Pickering emulsion was prepared with SiO2 nanoparticles and tetradecyldiethylenetriamine （C14DETA） as emulsifiers and n-decane as oil phase. At 25 ℃, the emulsion could be smartly switched “on （stable）” and “off （unstable）” by bubbling CO2 and N2 alternately. C14DETA was protonated into C14DETA-CO2 by bubbling CO2, and then adsorbed to the surface of negatively charged SiO2 particles through electrostatic interaction, resulting in in-situ hydrophobic effect and transforming SiO2 particles into surface-active particles and thus stabilizing the emulsion. However, C14DETA-CO2 was deprotonated into C14DETA by bubbling N2, which induced the elimination of in-situ hydrophobic effect, thus leading to complete demulsification of the emulsion. The emulsifying conditions were optimized: the volume ratio of oil/water was 1:1; the mass fraction of SiO2 particles was 0.05% and the concentration of C14DETA-CO2 was 2×10-3 mol/L. The Pickering emulsion needed less surfactant and had stronger stability than the emulsion with C14DETA as the surfactant. 数据和表 | 参考文献 | 相关文章 | 计量指标

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复方紫草凝胶外用制剂的抗炎与抑菌作用研究 Study on the anti-inflammatory and antibacterial effects of compound radix arnebiae gel topical preparation 贾颖,王佳敏,王世晖,刘凯丽,杨大伟,王艳 2020 (12):  848-853.  doi: 10.3969/j.issn.1001-1803.2020.12.006 摘要 ( 692 )   HTML ( 13 )   PDF(1085KB) ( 530 )   采用三元相图法筛选复方紫草凝胶外用制剂（CRAGTP）处方;使用3种急性炎症模型：二甲苯致小鼠耳肿胀、二甲苯和醋酸增加毛细血管通透性研究CRAGTP的抗炎作用;K-B纸片扩散法研究了CRAGTP对金黄色葡萄球菌（Staphylococcus aureus, SA）、大肠杆菌（Escherichia coli, E.coli）、铜绿假单胞菌（Pseudomonas areuginas, PA）的体外抑菌作用。结果显示,CRAGTP处方为复方紫草提取物0.5%、油相26.0%、表面活性剂40.2%、助表面活性剂（甘油）3.3%、水30.0%,外观澄清透明,pH=6.49,粒径为22.64 nm。CRAGTP能抑制二甲苯致急性炎症（P<0.01）、醋酸致急性炎症（P<0.05）;CRAGTP对SA和E.coli有抑制作用,对PA几乎没有抑制作用。CRAGTP抗炎作用良好,有一定的抑菌作用。 The optimal formulation of compound radix arnebiae gel topical preparation （CRAGTP） was screened by ternary phase diagram. Three acute inflammation models （xylene-induced ear swelling, xylene-induced abdominal skin capillary permeability increase, and acetic acid-induced abdominal cavity capillary permeability increase） were used to study the anti-inflammatory effects of CRAGTP. Disc diffusion test （K-B method） was used to study the inhibitory effect of CRAGTP on Staphylococcus aureus （SA）, Escherichia coli （E.coli） and Pseudomonas areuginas （PA） in vitro. Preliminary results show that the optimal composition of CRAGTP formulation is 0.5% of compound radix arnebiae extract, 26.0% of oil phase mixture, 40.2% of surfactants, 3.3% of glycerin and 30.0% of water. The formulated gel is clear and transparent, with pH of 6.49 and particle size of 22.64 nm. CRAGTP shows great ability to inhibit the xylene-induced ear swelling （P<0.01）, xylene-induced increasing of abdominal skin capillary permeability （P<0.01）, and acetic acid-induced increasing of abdominal cavity capillary permeability （P<0.05）. It has an inhibitory effect on SA and E.coli, but has little inhibitory effect on PA. CRAGTP has a good anti-inflammatory effect and a certain antibacterial activity. 数据和表 | 参考文献 | 相关文章 | 计量指标

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基于图像分析的化妆品紧致功效评价方法研究 Evaluation of cosmetics firming efficacy based on image analysis 杨泽茹,韦月仙,范展华,刘琦,王敏,赵华 2020 (12):  854-860.  doi: 10.3969/j.issn.1001-1803.2020.12.007 摘要 ( 745 )   HTML ( 21 )   PDF(1124KB) ( 647 )   基于抗衰老功效评价,以图像分析法为依据,参考医学面部评价方法,通过采集使用功效化妆品前后受试者面部图像,应用计算机软件分析受试者面部特征点数据改变规律,寻找研究面部皮肤紧致提升的数据化方法。经验证下半面宽度、鼻唇角、眼部角度A及眼部角度B有统计学意义（P<0.05）,应用于抗衰老护肤品紧致及提升面部的功效评价,可通过测算角度改变程度来评价产品功效强弱,补充和完善现有护肤品功效评价方法,使评价体系更加丰富立体。 Based on the evaluation of anti-aging efficacy, on the basis of image analysis method and referring to medical facial evaluation methods, by collecting the subjects’ facial images before and after using the functional cosmetics, and using computer software to analyze the changing rules of subjects’ facial feature point data, a data-based method for the study of facial skin firmness was found. It is proved that the lower half width, nasal-lip angle, eye angle A and eye angle B are statistically significant （P<0.05） , which can be used to evaluate the efficacy of anti-aging skin care products to firm and lift the face. The efficacy of the product can be evaluated by measuring the degree of change in the angle, supplement and improve the existing efficacy evaluation methods of skin care products, and make the evaluation system richer and more stereoscopic. The existing skin care efficacy evaluation methods can be supplemented and improved to make the evaluation system more abundant and stereoscopic. 数据和表 | 参考文献 | 相关文章 | 计量指标

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部分市售抑菌牙膏对7种常见口腔致病菌的体外抑制评价 Evaluation of in vitro inhibition of some commercial antibacterial toothpastes against 7 common oral pathogenic bacteria 邱希斌,宋帆,许任伟,林诗涵,林钊,黄姝玲,许亚煊 2020 (12):  861-866.  doi: 10.3969/j.issn.1001-1803.2020.12.008 摘要 ( 393 )   HTML ( 13 )   PDF(941KB) ( 451 )   为调查市售标称具有抑菌效果或抗菌作用牙膏的效果,研究引入杯碟法对常见口腔致病细菌进行抑菌效果实验,主要选用嗜酸乳杆菌（Lactobacillus acidophilus,LA）、粪肠球菌（Enterococcus faecalis,EF）、金黄色葡萄球菌（Staphylococcus aureus,SA）、牙龈卟啉单胞菌（Porphyromonas gingivalis,PG）、白色念珠菌（S. mutans,SM）、变形链球菌（Streptococcus mutans clarke,SMC）、铜绿假单胞菌（Pseudomonas aeruginosa,PA）。结果显示,16种供试牙膏针对7种常见口腔致病菌均出现不同程度的抑菌圈;同步开展了供试牙膏的MIC、MBC实验,并简要分析了实验方法的优势与所选市售标称抑菌牙膏的现实状况,对牙膏宣传功效的规范与标称用语的使用提供了一定的建议。 In order to investigate the efficacy of commercial toothpastes with bacteriostatic effect or antibacterial effect, the cylinder plate method was introduced to test the bacteriostatic effect on common oral pathogenic bacteria. Lactobacillus acidophilus （LA）, Enterococcus faecalis （EF）, Staphylococcus aureus （SA）, Porphyromonas gingivalis （PG）, S. mutans （SM）,Streptococcus mutans clarke （SMC）, and Pseudomonas aeruginosa （PA） were mainly selected. The results show that 16 kinds of toothpastes tested have different degrees of inhibition zones against 7 common oral pathogenic bacteria. MIC and MBC experiments of the tested toothpastes were carried out simultaneously, and the advantages of the experimental methods and the actual status of the selected commercial antibacterial toothpastes were briefly analyzed. Some suggestions are provided for the specification of the efficacy claims and nominal terms of toothpaste promotion. 数据和表 | 参考文献 | 相关文章 | 计量指标

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当归提取物对毛发生长作用的体外与体内研究 Study on the effects of Angelica sinensis on hair growth in vitro and in vivo 高合意,雷登凤,程树军,陈志杰,刘仁龙 2020 (12):  867-874.  doi: 10.3969/j.issn.1001-1803.2020.12.009 摘要 ( 970 )   HTML ( 17 )   PDF(1507KB) ( 717 )   研究当归提取物在防脱育发功效中的作用。制备当归水提取物,采用Ⅱ型5α-还原酶抑制模型、C57BL/6小鼠动物实验模型和人群试用方法,分别进行酶抑制率、动物皮肤形态组织学观察和临床观察。结果表明0.5 g/mL的当归提取物可明显抑制Ⅱ型5α-还原酶的活性;动物实验结果表明,当归提取物对C57BL/6小鼠毛发生长有明显促进作用,刺激小鼠毛囊从休止期进入生长期;人体功效试验结果表明,使用当归提取物制备的头皮护理精华液7周后,80%志愿者的脱发症状得到改善。综合体外和体内研究结果表明：当归提取物具有促进小鼠毛发生长、改善脱发人群脱发症状的功效。 The effects of the extract of Angelica sinensis on anti-hair loss and hair growth were studied. The efficacy of the extract of Angelica sinensis was evaluated by using different methods such as the model of 5α-reductase inhibition, animal test and human efficacy test. The results showed that this material could inhibit the activity of 5α-reductase in vitro with a dose of 0.5 g/mL. Animal test showed that it could obviously promote hair growth of C57BL/6 mice, and it could induce the hair follicle to enter from telogen into anagen. Human efficacy test showed that the hair loss symptoms could be reduced after using the scalp care essence containing the extract of Angelica sinensis for 7 weeks. In conclusion, the extract of Angelica sinensis could stimulate the hair growth of C57BL/6 mice, and it could help the patients with hair loss symptoms. 数据和表 | 参考文献 | 相关文章 | 计量指标

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两种评价牙膏预防外源性色素沉积功效方法的比较 Comparison of two methods for evaluating the toothpastes on the efficacy of prevention of extrinsic staining 谢宇,李慧怡,周悦,叶蓉姿,谢嘉颖,谭建华 2020 (12):  875-878.  doi: 10.3969/j.issn.1001-1803.2020.12.010 摘要 ( 372 )   HTML ( 9 )   PDF(925KB) ( 565 )   分别采用紫外吸收光谱法和色差法评价了5款市售牙膏预防外源性色素沉积功效,并结合牙膏中植酸钠、三聚磷酸钠、焦磷酸钠3种功效成分的总含量对比分析了两种功效评价方法的差异。结果显示,紫外吸收光谱法与色差法所得5款牙膏预防外源性色素沉积功效高低结论相近,且与牙膏中植酸钠、三聚磷酸钠、焦磷酸钠的总含量高低呈正相关。同时,该研究尝试采用相关性分析和组内相关系数检验对两种评价方法的结果间等价性进行了初步分析。结果显示,两种评价方法的结果间存在中度正相关关系,R2=0.725;组内相关系数ICC值为0.852 （P<0.05）,提示两种方法测量结果从统计学角度可认为有等价性。 The efficacy of prevention of extrinsic staining were evaluated for 5 commercial toothpastes by two methods, i.e., UV-Vis absorption spectrometry and colorimetric method. Combined with the quantities of sodium phytate, sodium tripolyphosphate and sodium pyrophosphate in each toothpaste, the differences between the results of the two methods were compared. The results showed that, similar rankings among the 5 toothpastes are obtained for the two methods in evaluating the efficacy of prevention of extrinsic staining; in addition, the total quantity of the three active ingredients （i.e., sodium phytate, sodium tripolyphosphate and sodium pyrophosphate） is positively correlated with the efficacy of prevention of extrinsic staining. Furthermore, pearson correlation coefficient and intra-class correlation coefficients （ICC） were used to analyze the preliminary results obtained from the two methods. In conclusion, moderate positive correlation was found between the two results, i.e., R2=0.725; moreover, ICC=0.852 （P<0.05）, indicating that the results of UV-Vis absorption spectrometry and colorimetric method were statistically consistent. 数据和表 | 参考文献 | 相关文章 | 计量指标

专论与综述

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新旧化妆品监督管理条例对化妆品注册备案管理的对比研究 Comparative study of the new and old “Regulations on Supervision and Administration of Cosmetics” on the administration of cosmetics registration and notification 袁欢,唐霖,陈超,张凤兰,王钢力 2020 (12):  879-884.  doi: 10.3969/j.issn.1001-1803.2020.12.011 摘要 ( 725 )   HTML ( 47 )   PDF(882KB) ( 467 )   通过将《化妆品监督管理条例》中的条款内容与原《化妆品卫生监督条例》内容进行对比,研究分析了《化妆品监督管理条例》对化妆品、化妆品新原料注册备案管理调整的思路及举措,为相关监管及从业人员提供参考。 By comparing the provisions in the “Regulations on Supervision and Administration of Cosmetics” with the contents in the original “Regulations on Hygiene Supervision of Cosmetics”, this paper studied and analyzed the thoughts and measures of the “Regulations on Supervision and Administration of Cosmetics” on the adjustment of the registration and notification management of cosmetics and new ingredients. It provides reference for the regulators and cosmetics practitioners. 参考文献 | 相关文章 | 计量指标

分析与检测

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UHPLC-MS/MS法测定网络销售婴幼儿湿疹类产品中43种糖皮质激素类药物 Determination of 43 glucocorticoids in infant eczema products by UHPLC-MS/MS 董亚蕾,刘钊,王海燕,孙磊 2020 (12):  885-891.  doi: 10.3969/j.issn.1001-1803.2020.12.012 摘要 ( 525 )   HTML ( 41 )   PDF(1219KB) ( 546 )   建立了快速、准确测定网络销售婴幼儿湿疹类产品中43种糖皮质激素类药物的超高效液相色谱-串联三重四级杆质谱（UHPLC-MS/MS）检测方法。对样品前处理条件、色谱和质谱条件进行了优化,最终样品以乙腈超声提取,提取液稀释后直接进样,采用UHPLC-MS/MS在多重反应监测（MRM）模式下进行定性筛查。对筛查结果疑似阳性的样品,根据保留时间和特征离子对的相对丰度比定性,并采用定量离子对进行外标法定量。采用该方法对网络销售的41批湿疹相关“妆”字号产品和“消”字号产品进行检测,其中有6批产品中检出糖皮质激素,两类产品的检出率分别为5.9%和57.1%。该方法操作简便、准确可靠,可用于实际样品检测的需要,为化妆品安全监管提供技术支撑。 A fast and accurate method for the determination of 43 kinds of glucocorticoids in infant eczema products by UHPLC-MS/MS was established. The samples were extracted with acetonitrile ultrasonically. The supernatant was diluted and injected directly. After optimizing the sample pretreatment and chromatography conditions, as well as mass spectrometry parameters, UHPLC-MS /MS analysis method was performed for qualitative screening in MRM mode. The samples with suspected positive screening results were further confirmed. Qualitative analysis was conducted according to retention time and relative abundance ratio of characteristic ion pairs. Quantitative ion pairs were used for quantitative measurement by external standard method. This method was used for detecting 41 batches of eczema-related cosmetic products and disinfection products sold online. Glucocorticoids were detected in 6 batches of products, and the detection rates of the two types of products were 5.9% and 57.1%, respectively. The method is simple, accurate and reliable, which can be used for the actual sample detection and provide technical support for cosmetic safety supervision. 数据和表 | 参考文献 | 相关文章 | 计量指标

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头发表面静电的测试 Test for static electricity on hair surface 王志华, 姚晨之 2020 (12):  892-895.  doi: 10.3969/j.issn.1001-1803.2020.12.013 摘要 ( 1195 )   HTML ( 35 )   PDF(1127KB) ( 464 )   通过模拟日常生活中梳理头发的动作,对标准发束表面静电压大小进行测定,确立了头发表面静电压大小的表达指标。实验结果显示,梳子离开头发瞬间所产生的最大静电压可以用来表征该发束的静电压大小。头发表面静电压大小与环境湿度、摩擦强度、自身受损程度密切相关。该方法能直接对发束表面静电压大小进行定量测试,操作简便、快速、重现性高,可用于抗静电产品的快速检测。 By simulating the action of combing hair in daily life and measuring the static voltage on the surface of the standard hair tress, the expression index of the static voltage on the surface of the hair was established. The experimental results show that the maximum static voltage generated when the comb leaves the hair can be used to characterize the static voltage of the hair tress. The static voltage on the hair surface is closely related to the environmental humidity, friction strength, and the damage degree of hair fibers. This method can directly quantify the static voltage on the surface of the hair tress, and is easy to operate, fast, and highly reproducible. It can be used for rapid detection of antistatic products. 数据和表 | 参考文献 | 相关文章 | 计量指标

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荧光检测法快速测定化妆品中违禁成分酸性黄36 Rapid fluorescence detection of prohibited cosmetic ingredient metanil yellow 刘岱拯,柳亚峰,谢珍茗 2020 (12):  896-900.  doi: 10.3969/j.issn.1001-1803.2020.12.014 摘要 ( 377 )   HTML ( 6 )   PDF(1490KB) ( 597 )   建立了基于次氯酸氧化偶氮断裂的荧光检测法对化妆品中违禁成分酸性黄36的快速测定。该方法利用次氯酸作为荧光转移引发剂,引发酸性黄36的荧光发射信号转变来实现快速检测。通过探究反应溶剂、pH、反应时间等影响因素优化检测体系。结果表明,酸性黄36在pH=7的乙腈PBS溶液（体积比9:1）,270 nm激发波长下,345 nm处出现强荧光发射。随着次氯酸的加入,荧光发射猝灭,并于395 nm处出现强烈的荧光发射。室温下反应所需时间小于40 min。检测线性为0.2~32 μg/mL,相关系数r2=0.993 9。最低检测限为0.2 μg/mL,该方法具有良好的特异性,在真实样品中的平均回收率在90.5%~112.6%,RSD低于4.54%。 A fluorescence method based on hypochlorous acid azo cleavage was established for the rapid determination of metanil yellow which was a prohibited ingredient in cosmetics. Hypochlorous acid was used as a fluorescence transfer initiator to trigger the conversion of the fluorescence emission signal of metanil yellow to achieve the rapid detection. By exploring the factors such as solvent, pH and reaction time, the optimal detection system was obtained. The results showed that metanil yellow showed a strong fluorescence emission at 345 nm with an excitation wavelength of 270 nm in acetonitrile-PBS buffer （V/V=9:1） solution at pH of 7. With the addition of hypochlorous acid, the fluorescence emission was quenched and a strong fluorescence emission appeared at 395 nm. The reaction time at room temperature was less than 40 min. The linear range of detection was 0.2-32 μg/mL, and the correlation coefficient was r2=0.993 9. The limit of detection was 0.2 μg/mL, and the method had good specificity. The average recovery in real samples was 90.5%-112.6% with the RSD less than 4.54%. 数据和表 | 参考文献 | 相关文章 | 计量指标