阿魏酸皮肤生理作用及其化妆品包载技术研究进展

doi:10.3969/j.issn.2097-2806.2023.09.011

摘要/Abstract

摘要：

阿魏酸具有美白、抗衰、防晒等良好的皮肤生理作用，可作为一种功效原料应用到化妆品中。目前阿魏酸在医药、食品和农业等领域中应用广泛，在化妆品领域还处在研究发展阶段。本文主要从阿魏酸的皮肤生理作用出发，阐述了阿魏酸美白、抗衰、抗氧化等生理活性及其良好的应用前景。但由于阿魏酸在水中的溶解度差，性质不稳定，在化妆品中的应用受到了限制，为此很多研究者用多种方法来改善阿魏酸的应用性。其中，包载技术是将阿魏酸包裹起来添加到化妆品中，不仅能够提高阿魏酸的溶解度，还提高了它在化妆品配方中的配伍性。本文总结归纳了几种常用的包载技术，包括磷脂复合物、纳米乳、环糊精包合物、水凝胶、分子笼等，为阿魏酸在化妆品中的研发和应用提供重要参考。

关键词: 阿魏酸, 皮肤生理作用, 化妆品应用, 包载技术

Abstract:

Ferulic acid has good skin physiology effects such as whitening, anti-aging and sun protection, and can be used as a raw material in cosmetics. At present, ferulic acid is widely used in medicine and food, and it is still in the research and development stage in cosmetics. This review mainly elaborated the physiological activities of ferulic acid such as whitening, anti-aging, sunscreen and its application in cosmetics. Due to the poor solubility in water and the unstable properties of ferulic acid, its application in cosmetics is limited. For this reason, many efforts have been made to improve the applicability of ferulic acid. Among them, the encapsulation technology is to wrap ferulic acid and then apply it to cosmetics, which can not only improve the solubility of ferulic acid, but also increase the compatibility of ferulic acid in cosmetic formulations. This paper summarizes several commonly used encapsulation technologies, including phospholipid complexes, nanoemulsion, cyclodextrin inclusion complexes, hydrogels, molecular cages, etc., which provide significant references for the development and application of ferulic acid in cosmetics.

Key words: ferulic acid, skin physiological function, cosmetic application, encapsulation technology

中图分类号:

TQ658

熊洁, 杨丹, 孟宏, 何一凡, 裴晓静. 阿魏酸皮肤生理作用及其化妆品包载技术研究进展[J]. 日用化学工业（中英文）, 2023, 53(9): 1073-1079.

Xiong Jie, Yang Dan, Meng Hong, He Yifan, Pei Xiaojing. Research progress in skin physiological effects and its cosmetic encapsulation technology of ferulic acid[J]. China Surfactant Detergent & Cosmetics, 2023, 53(9): 1073-1079.

图/表 3

参考文献 45

[1]	Zhang Xin, Gao Zengping. Research progress of ferulic acid[J]. Modern Chinese Medicine, 2020, 22 (1) : 138-147.
[2]	Zhou Cairong, Shi Xiaohua, Wang Haifeng, et al. Solubility of trans-ferulic acid in solvent[J]. Journal of Chemical Engineering, 2007, 58 (11) : 2705-2709.
[3]	Cho J, Kim H, Kim Y. The study on depigmentation effects of salt, acetum, sesami semen nigrum[J]. The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, 2003, 16 (2) : 79-95.
[4]	Gilchrest B A, Eller M S. DNA photodamage stimulates melanogenesis and other photoprotective responses[C]// Journal of Investigative Dermatology Symposium Proceedings. Elsevier, 1999, 4 (1) : 35-40.
[5]	Ren Qianqian, Wu Hua, Jin Jianming. Cosmetic raw materials (Ⅳ): Research and development of plant whitening materials that inhibit melanin synthesis signal pathway[J]. China Surfactant Detergent & Cosmetics, 2021, 51 (7): 8.
[6]	Park H J, Cho J H, Hong S H, et al. Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells[J]. Journal of Natural Medicines, 2018.
[7]	Bezerra G S N, Pereira M A V, Ostrosky E A, et al. Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR[J]. Journal of Thermal Analysis & Calorimetry, 2017, 127 (2) : 1683-1691.
[8]	Aguilar-Hernández I, Afseth N K, López-Luke T, et al. Surface enhanced Raman spectroscopy of phenolic antioxidants: A systematic evaluation of ferulic acid, p-coumaric acid, caffeic acid and sinapic acid[J]. Vibrational Spectroscopy, 2017, 89: 113-122. doi: 10.1016/j.vibspec.2017.02.002
[9]	Huang Huayong, Shen Haixing, Zhen Jinhong. Synthesis of ferulic acid and its analogues and their free radical scavenging activities[J]. Chinese Journal of New Drugs, 2006 (6) : 454-458.
[10]	Wang A S, Dreesen O. Biomarkers of Cellular Senescence and Skin Aging[J]. Frontiers in Genetics, 2018, 9: 247. doi: 10.3389/fgene.2018.00247 pmid: 30190724
[11]	Xv Xiaoqing, Cheng Hui, Yang Sen. New progress in endogenous skin aging research[J]. China Journal of Leprosy and Skin Diseases, 2022, 38 (5) : 334-337.
[12]	Ravanat J L, Douki T, Cadet J. Direct and indirect effects of UV radiation on DNA and its components[J]. Journal of Photochemistry and Photobiology B: Biology, 2001, 63 (1-3) : 88-102. doi: 10.1016/S1011-1344(01)00206-8
[13]	Staianz K D. Ferulic acid inhibits UVA-induced photoaging in human skin fibroblasts through telomere pathway[D]. Suzhou: Suzhou University, 2016.
[14]	Pluemsamran T, Onkoksoong T, Panich U. Caffeic acid and ferulic acid inhibit UVA-induced matrix metalloproteinase-1 through regulation of antioxidant defense system in keratinocyte HaCaT cells[J]. Photochemistry and Photobiology, 2012, 88 (4) : 961-968. doi: 10.1111/j.1751-1097.2012.01118.x pmid: 22360712
[15]	Ambothi K, Nagarajan R P. Ferulic acid prevents ultraviolet-B radiation induced oxidative DNA damage in human dermal fibroblasts[J]. International Journal of Nutrition, Pharmacology, Neurological Diseases, 2014, 4 (4) : 203-213. doi: 10.4103/2231-0738.139400
[16]	Jin H H, Bbeum K K, Seunghee B, et al. Pretreatment of ferulic acid protects human dermal fibroblasts against ultraviolet A irradiation[J]. Annals of Dermatology, 2016, 28 (6) : 740-748. doi: 10.5021/ad.2016.28.6.740 pmid: 27904274
[17]	Du Kesi, Li Zeqiao, Zhang Baojiang, et al. Appearance changes and formation factors of skin aging[J]. China Surfactant Detergent & Cosmetics, 2022, 52 (2) : 199-206.
[18]	Sompong W, Cheng H, Adisakwattana S. Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells[J]. Journal of Physiology and Biochemistry, 2016, 73 (1) : 1-11. doi: 10.1007/s13105-016-0536-y
[19]	Sinicropi M S, Caruso A, Conforti F, et al. Synthesis, inhibition of NO production and antiproliferative activities of some indole derivatives[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24 (5) : 1148-1153. doi: 10.1080/14756360802693890 pmid: 19555184
[20]	Huang Y S, Ho S C. Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel[J]. Food Chemistry, 2010, 119 (3) : 868-873. doi: 10.1016/j.foodchem.2009.09.092
[21]	Wu J L, Shen M M, Yang S X, et al. Inhibitory effect of ferulic acid on neuroinflammation in LPS-activated microglia[J]. Chinese Pharmacological Bulletin, 2015, 31 (1) : 97-102.
[22]	Huang Congshu. Preliminary study on the effect of ferulic acid on radiation-induced skin injury[D]. Guangzhou: Guangdong Pharmaceutical University, 2021.
[23]	Guo Huiyi, Zhou Xinxin, Jiang Dan. In vitro drug sensitivity test of four kinds of Chinese herbal medicines and their compounds against Malassezia[J]. Chinese Journal of Mycology, 2013, 8 (4) : 210-213.
[24]	Wang Gang, Zhang Xiuhua, Yang Jinxia, et al. Protective effect of ferulic acid on human keratinocytes[J]. Medical Guide, 2011, 30 (8): 3.
[25]	Krutmann, Jean. Ultraviolet A radiation-induced biological effects in human skin: relevance for photoaging and photodermatosis[J]. Journal of Dermatological Science, 2000, 23: 22-26. doi: 10.1016/S0923-1811(99)00061-4
[26]	Nishigori C, Hattori Y, Arima Y, et al. Photoaging and oxidative stress[J]. Experimental Dermatology, 2003, 12 Suppl 2 (2) : 18-21.
[27]	D’Almeida P D, Daud S F, Areias D O C, et al. Ferulic acid photoprotective properties in association with UV filters: multifunctional sunscreen with improved SPF and UVA-PF[J]. Journal of Photochemistry & Photobiology B Biology, 2018, 185: 46-49.
[28]	Vasantha V A, Biying A O, Zhao W G, et al. Tunable, hybrid 1D ZnO nanostructures obtained by using bio‐renewable ferulic acid as support and its applications[J]. Chemistry Select, 2018.
[29]	Lin F H, Lin J Y, Gupta R D, et al. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin[J]. Journal of Investigative Dermatology, 2005, 125 (4): 826. doi: 10.1111/j.0022-202X.2005.23768.x
[30]	Wang Q J, Gao X, Gong H, et al. Chemical stability and degradation mechanisms of ferulic acid (F.A) within various cosmetic formulations[J]. Journal of Cosmetic Science, 2011, 62 (5) : 483-503.
[31]	Ding M Y, Ma S W, Liu D L. Stability of ferulic acid and its existing form in Ligusticum chuanxiong and Angelica sinensis[J]. Chinese Traditional and Herbal Drugs, 2004, 35: 28-30.
[32]	Bezerra G S N, Pereira M A V, Ostrosky E A, et al. Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR[J]. Journal of Thermal Analysis & Calorimetry, 2017, 127 (2) : 1683-1691.
[33]	Talware N S, Dias R J, Gupta V R. Recent approaches in the development of Phytolipid complexes as novel drug delivery[J]. Current Drug Delivery, 2018, 15 (6) : 755-764. doi: 10.2174/1567201815666180209114103 pmid: 29424315
[34]	Liang Na, Shi Kai, Wang Yongsheng, et al. Preparation and physical properties of ferulic acid-phospholipid complex[J]. Journal of Shenyang Pharmaceutical University, 2008, 25 (3) : 163-168.
[35]	Nastiti C M R R, Ponto T, Abd E, et al. Topical nano and microemulsions for skin delivery[J]. Pharmaceutics, 2017, 9 (4): 37. doi: 10.3390/pharmaceutics9040037
[36]	Gupta K M, Das S, Chow P S, et al. Encapsulation of ferulic acid in lipid nanoparticles as antioxidant for skin: mechanistic understanding through experiment and molecular simulation[J]. ACS Applied Nano Materials, 2020, 3 (6) : 5351-5361. doi: 10.1021/acsanm.0c00717
[37]	Jiang Xingcan, Li Bing, Zhang Jiyu. Progress in preparation and characterization of cyclodextrin inclusion supramolecular system[J]. Advances in Animal Medicine, 2021, 42 (3) : 96-101.
[38]	Gao Ruiying, Mu Dan, Fu Zhong, et al. Preparation and characterization of ferulic acid/α-cyclodextrin inclusion complex[J]. China Surfactant Detergent & Cosmetics, 2010, 40 (2): 4.
[39]	Mori T, Tsuchiya R, Doi M, et al. Solubilization of ultraviolet absorbers by cyclodextrin and their potential application in cosmetics[J]. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2019, 93 (1-2) 91-96. doi: 10.1007/s10847-018-0846-5
[40]	Qi L, Zhang C, Wang B, et al. Progress in hydrogels for skin wound repair[J]. Macromolecular Bioscience, 2022: 2100475.
[41]	Chen Lei. Effect and mechanism of ferulic acid thermosensitive gel on spinal cord injury[D]. Huangzhou: Zhejiang University of Traditional Chinese Medicine, 2016.
[42]	Tao Ling, He Liangfei, Guang Yongmei, et al. Preparation and percutaneous permeability of triptolide ferulic acid ethosome gel[J]. China Journal of Traditional Chinese Medicine, 2018, 43 (6): 6.
[43]	Grimaudo M A, Amato G, Carbone C, et al. Micelle-nanogel platform for ferulic acid ocular delivery[J]. International Journal of Pharmaceutics, 2020, 576: 118986. doi: 10.1016/j.ijpharm.2019.118986
[44]	Zhang Y, Dong Y, Li X, et al. Proanthocyanidin encapsulated in ferritin enhances its cellular absorption and antioxidant activity[J]. Journal of Agricultural and Food Chemistry, 2019, 67 (41) : 11498-11507. doi: 10.1021/acs.jafc.9b03903 pmid: 31544455
[45]	Zheng Zhongbo, Cong Yuanhua, Feng Chunbo. Solubilization of ferulic acid and its stability in oil products[J]. Flavour Fragrance Cosmetics, 2021 (4): 4.