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日用化学工业（中英文）

日用化学工业 ›› 2017, Vol. 47 ›› Issue (7): 418-420.doi: 10.13218/j.cnki.csdc.2017.07.013

• 分析与检测 • 上一篇    

高效液相色谱法同时测定化妆品中5种防腐剂

张卓娜, 林少彬, 杨艳伟   

  1. 中国疾病预防控制中心 环境与健康相关产品安全所,北京 100021
  • 收稿日期:2017-01-24 发布日期:2019-03-20
  • 通讯作者: 杨艳伟,主任技师,电话:(010)50930161,E-mail:yangyw6020@sina.com。
  • 作者简介:张卓娜(1986-),女,山东人,助理研究员,硕士,电话:(010)50930170,E-mail:zhuona86@sina.com。

Simultaneous determination of five kinds of preservative in cosmetics by high performance liquid chromatography

ZHANG Zhuo-na, LIN Shao-bin, YANG Yan-wei   

  1. Institute of Environmental Health and Related Product Safety,Chinese Center for Disease Control and Prevention,Beijing 100021,China
  • Received:2017-01-24 Published:2019-03-20

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摘要： 建立了同时测定化妆品中5种防腐剂的高效液相色谱分析方法。采用C18色谱柱(250 mm×4.6 mm,5 μm)分离,以甲醇-水为流动相,流速为1.0 mL/min,检测波长为230 nm,柱温25 ℃。结果表明,5种防腐剂的线性范围为0~200 mg/L,方法的线性关系良好,5种防腐剂氯苯甘醚、邻苯基苯酚、氯二甲酚、苄氯酚和三氯生的检出限分别为0.10,0.10,0.15,0.25和0.30 mg/L。样品的平均加标回收率为97.6%~115%,相对标准偏差为0.30%~1.65% (n=6)。

关键词: 化妆品添加剂, 防腐剂, 高效液相色谱法

Abstract: A high performance liquid chromatography method was established for determination of five kinds of preservative in cosmetics.A C18 column (250 mm×4.6 mm,5 μm) was used as stationary phase,and methanol aqueous solution was used as mobile phase with a flow rate of 1.0 mL/min.The detection wavelength was set at 230 nm and the column temperature was 25 ℃.The linearity range of the five kinds of preservative is 0-200 mg/L,and the method shows a good linear relationship.The detection limits for chlorphenesin,biphenyl-2-ol,chloroxylenol,chlorophene and triclosan achieve 0.10,0.10,0.15,0.25 and 0.30 mg/L respectively.The spiked recovery rate varies from 97.6% to 115%.The relative standard deviation achieves 0.30%-1.65% (n=6).

Key words: additive of cosmetics, preservative, high performance liquid chromatography

中图分类号: 

  • TQ658