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日用化学工业（中英文）

日用化学工业 ›› 2014, Vol. 44 ›› Issue (1): 54-56.doi: 10.13218/j.cnki.csdc.2014.01.013

• 分析与检测 • 上一篇    

高效液相色谱法检测防脱、育发类化妆品中的非那雄胺

刘亚雄1, 吴达萍1, 孙婷婷2   

  1. 1.广东省食品药品检验所 化妆品室,广东 广州 510180;
    2.广东省食品药品职业技术学院 药学院,广东 广州 510520
  • 收稿日期:2013-08-13 发布日期:2019-04-09
  • 作者简介:刘亚雄(1977-),男,博士,E-mail:yaxiongliu@foxmail.com。

Determination of finasteride in anti-calvous hair cosmetics by high performance liquid chromatography

LIU Ya-xiong1, WU Da-ping1, SUN Ting-ting2   

  1. 1.Department of Cosmetics,Guangdong Institute for Food and Drug Control,Guangzhou,Guangdong 510180,China;
    2.School of Pharmacy,Guangdong Food and Drug Vocational College,Guangzhou,Guangdong 510520,China
  • Received:2013-08-13 Published:2019-04-09

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摘要： 采用高效液相色谱法测定防脱、育发类化妆品中的非那雄胺,色谱条件为Zorbax Extend C18柱(250 mm×4.6 mm,5 μm),流动相为乙腈/10 mmol·L-1磷酸二氢钾梯度洗脱体系,流速为1.0 mL·min-1,检测波长为220 nm,柱温为30 ℃。实验结果表明,在此条件下非那雄胺在0.8～20 mg·L-1与相应的峰面积具有良好的线性关系(R2=0.999 0),回收率为90.3%～102.0%。

关键词: 发用化妆品, 非那雄胺, 高效液相色谱法

Abstract: A reversed-phase high performance liquid chromatography for the determination of finasteride in anti-calvous hair cosmetics was established.The sample was analyzed on a Agilent Zorbax Extend C18 column (250 mm×4.6 mm,5 μm) with detecting wavelength of 220 nm at 30 ℃,and eluted by mobile phase composed of acetonitrile (CH3CN) and KH2PO4 (10 mmol·L-1) with a gradient model,at a flow rate 1.0 mL min-1.Results showed that as the mass concentration of finasteride is in the range of 0.8-20 mg·L-1,the relationship between the mass concentration and the corresponding peak area shows good linearity (R2=0.999 0).The recoveries of finasteride achieve 90.3%-102.0%.

Key words: sterile hair cosmetics, finasteride, high performance liquid chromatography

中图分类号: 

  • TQ658