一款舒缓凝胶的临床功效评测研究

doi:10.3969/j.issn.1001-1803.2021.04.008

Abstract

Abstract:

Self-developed soothing gel was tested on the clinical efficacy and its soothing effect was evaluated. At the inception of the study, 30 healthy volunteers at the age of 18-55 were selected. Their skin barriers had been destroyed by means of repeatedly tearing the adhesive tapes and the skin models was built by the stimulation of histamine solution. Then the medial forearm photos and skin erythema index （EI values） after using the soothing gel for 15, 40, 60 and 90 minutes were collected. The redness, swelling, stinging and itching could be evaluated by expert evaluation and self-evaluation. The results show that the soothing gel can effectively improve the redness and swelling of skin after stimulation. It also relieves itching and pain, and its effect is significantly better than that of skin self-repair. This indicates that soothing repair gel has a certain effect on soothing irritation.

Key words: soothing, clinical efficacy, gel

CLC Number:

TQ658

SUN Jin-yuan,CHEN Yi-qi,ZHAO Hua. Study on the clinical efficacy of a soothing gel[J].China Surfactant Detergent & Cosmetics, 2021, 51(4): 312-318.

Figures/Tables 10

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References 7

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相	成分	w/%
A相	乙醇	5
	羟苯基丙酰胺苯甲酸	0.1
	4-叔丁基环己醇	0.5
	红没药醇	0.12
	姜根提取物	0.05
	薄荷脑	0.1
B相	水	92.63
B相	聚丙烯酸酯交联聚合物-6	0.8
C相	苯氧乙醇	0.6
C相	乙基己基甘油	0.1

评估方式	评估要求	评分制	评估项
专家评估	由视感评价师对前臂内侧皮肤泛红、红肿的程度及整体状态进行分级打分	0分-无 1分-轻 2分-中 3分-重	泛红、红肿
自我评估	由受试者对自身皮肤状态进行自我评估	0分-无 1分-轻 2分-中 3分-重	泛红、红肿、刺痛、瘙痒、灼热感

组别	t/min	数据
		退红		消肿
		差值	组间差异	差值	组间差异
空白组	3	0	a	0	a
	8	0	a	0	a
	15	0	b	0	b
	40	0	c	0	c
	60	0	c	0	c
	90	0	c	0	c
阴性对照组	3	-0.01±0.09	a	-0.03±0.08	a
	8	-0.05±0.09	a	-0.1±0.08	a
	15	-0.15±0.09	b	-0.16±0.09	a
	40	-0.51±0.14^**	b	-0.66±0.13^***	b
	60	-0.88±0.15^***	b	-0.93±0.14^***	b
	90	-1.21±0.17^***	b	-1.26±0.14^***	b
实验组	3	-0.16±0.09	a	-0.08±0.11	a
	8	-0.19±0.09^*	a	-0.05±0.12	a
	15	-0.39±0.1^**	a	-0.31±0.15^*	a
	40	-0.98±0.15^***	a	-0.88±0.16^***	a
	60	-1.36±0.15^***	a	-1.25±0.15^***	a
	90	-1.73±0.14^***	a	-1.58±0.15^***	a

组别	t/min	数据
		退红		消肿
		差值	组间差异	差值	组间差异
空白组	3	0	b	0	a
空白组	8	0	c	0	b
空白组	15	0	c	0	b
	40	0	c	0	c
	60	0	c	0	c
	90	0	c	0	c
阴性对照组	3	-0.27±0.14	b	-0.06±0.13	a
	8	-0.30±0.12^*	b	-0.16±0.13	b
	15	-0.30±0.12^*	b	-0.33±0.14^*	b
	40	-0.57±0.12^***	b	-0.73±0.14^***	b
	60	-0.73±0.15^***	b	-0.86±0.13^***	b
	90	-1.17±0.17^***	b	-0.96±0.14^***	b
实验组	3	-0.40±0.13^**	a	-0.33±0.15^*	a
	8	-0.60±0.13^***	a	-0.43±0.16^*	a
	15	-0.77±0.11^***	a	-0.73±0.17^***	a
	40	-1.10±0.14^***	a	-1.27±0.17^***	a
	60	-1.40±0.12^***	a	-1.43±0.16^***	a
	90	-1.74±0.15^***	a	-1.47±0.16^***	a

组别	t/min	数据
		瘙痒		刺痛		灼热感
		差值	组间差异	差值	组间差异	差值	组间差异
空白组	3	0.07±0.05	b	-0.03±0.03	c	0	b
	8	0.04±0.03	b	-0.03±0.03	c	0	b
	15	0.04±0.03	c	0.03±0.03	c	0	b
空白组	40	0	c	0.03±0.03	c	0	c
	60	0	c	0.03±0.03	c	0	c
	90	0	c	0.03±0.03	c	0	c
阴性对照组	3	-0.44±0.19^***	a	-0.44±0.10^***	b	-0.23±0.09	a
	8	-0.64±0.18^*	a	-0.64±0.10^***	b	-0.30±0.09^*	a
	15	-0.80±0.18^**	b	-0.90±0.15^***	b	0^***	a
	40	-0.94±0.19^***	b	-0.87±0.15^***	b	-0.30±0.19^***	b
	60	-0.97±0.18^***	b	-0.97±0.15^***	b	-0.30±0.09^***	b
	90	-1.04±0.18^***	b	-0.97±0.15^***	b	-0.30±0.19^***	b
实验组	3	-0.83±0.20^***	a	-1.04±0.18^***	a	-0.40±0.13^***	a
	8	-1.03±0.19^***	a	-1.17±0.17^***	a	-0.47±0.13^**	a
	15	-1.26±0.19^***	a	-1.40±0.20^***	a	0^***	a
	40	-1.30±0.18^***	a	-1.34±0.18^***	a	-1.47±0.13^***	a
	60	-1.30±0.20^***	a	-1.47±0.20^***	a	-0.47±0.13^***	a
	90	-1.40±0.20^***	a	-1.47±0.20^***	a	-0.47±0.13^***	a

Study on the clinical efficacy of a soothing gel

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