神经调节在敏感肌肤中的作用

doi:10.3969/j.issn.2097-2806.2026.03.013

摘要/Abstract

摘要：

神经调节在皮肤健康和疾病中的作用正日益受到重视，其与皮肤敏感性、屏障功能、衰老和色素沉着等方面有着密切的关系。本文综述旨在探讨神经调节在敏感肌肤中的关键作用，从神经血管反应性、感官特征以及情绪护肤三个方面分析神经调节如何影响敏感肌肤，并对未来研究提出了建议。

关键词: 敏感肌, 神经介质, 情绪护肤, 神经血管反应性, 感觉受体

Abstract:

The role of neuromodulation in skin health and disease is increasingly recognized, as it is closely related to skin sensitivity, barrier function, aging, and pigmentation. This review aims to explore the critical role of neuromodulation in sensitive skin, analyzing its impact from three perspectives: neurovascular reactivity, sensory characteristics, and emotional skincare. Additionally, it proposes recommendations for future research directions.

Key words: sensitive skin, neurotransmitters, emotional skincare, neurovascular reactivity, sensory receptors

中图分类号:

TQ658

戚东萍,申凤同,张俊良,刘思聪,吴越. 神经调节在敏感肌肤中的作用[J]. 日用化学工业（中英文）, 2026, 56(3): 376-385.

Dongping Qi,Fengtong Shen,Junliang Zhang,Sicong Liu,Yue Wu. The role of neuromodulation in sensitive skin[J]. China Surfactant Detergent & Cosmetics, 2026, 56(3): 376-385.

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参考文献 59

[1]	吕中茜, 郭义. 反观中医临床提出“皮肤是人的第三大脑”[J]. 江西中医药, 2016, 47 (7) : 11-13.
[2]	Granstein R D, Luger T A. Neuroimmunology of the skin[M]. Springer Berlin Heidelberg, 2009.
[3]	龚石, 刘巧. 神经介质与皮肤美容关系的研究进展[J]. 中国美容医学, 2011, 20 (5) : 861-862.
[4]	Bove D, Lupoli A, Caccavale S, et al. Dermatological and immunological conditions due to nerve lesions[J]. Functional Neurology, 2013, 28 (2) : 83.
[5]	Roosterman D, Goerge T, Schneider S W, et al. Neuronal control of skin function: the skin as a neuroimmunoendocrine organ[J]. Physiological Reviews, 2006, 86 (4) : 1309-1379.
[6]	Rizzi V, Gubitosa J, Fini P, et al. Neurocosmetics in skincare-the fascinating world of skin-brain connection: a review to explore ingredients, commercial products for skin aging, and cosmetic regulation[J]. Cosmetics, 2021, 8 (3) : 66.
[7]	Schmidt R, Schmelz M, Forster C, et al. Novel classes of responsive and unresponsive C nociceptors in human skin[J]. Journal of Neuroscience, 1995, 15 (1) : 333-341.
[8]	Ständer S, Schneider S W, Weishaupt C, et al. Putative neuronal mechanisms of sensitive skin[J]. Experimental Dermatology, 2009, 18 (5) : 417-423.
[9]	Misery L. Sensitive skin[J]. Expert Review of Dermatology, 2013, 8(6) : 631-637.
[10]	Farage M A, Maibach H I. Sensitive skin: closing in on a physiological cause[J]. Contact Dermatitis, 2010, 62 (3) : 137-149.
[11]	Tóth B I, Oláh A, Szöllősi A G, et al. TRP channels in the skin[J]. British Journal of Pharmacology, 2014, 171 (10) : 2568-2581.
[12]	Zhang M, Ma Y, Ye X, et al. TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases[J]. Signal Transduction and Targeted Therapy, 2023, 8 (1) : 261.
[13]	Huet F, Misery L. Sensitive skin is a neuropathic disorder[J]. Experimental Dermatology, 2019, 28 (12) : 1470-1473.
[14]	Kumagai M, Nagano M, Suzuki H, et al. Effects of stress memory by fear conditioning on nerve-mast cell circuit in skin[J]. The Journal of Dermatology, 2011, 38 (6) : 553-561.
[15]	Yam M F, Loh Y C, Tan C S, et al. General pathways of pain sensation and the major neurotransmitters involved in pain regulation[J]. International Journal of Molecular Sciences, 2018, 19 (8) : 2164.
[16]	Buhé V, Vié K, Guéré C, et al. Pathophysiological study of sensitive skin[J]. Acta Dermato-venereologica, 2016, 96 (3) : 314-318.
[17]	Huet F, Dion A, Batardière A, et al. Sensitive skin can be small fibre neuropathy: results from a case-control quantitative sensory testing study[J]. British Journal of Dermatology, 2018, 179 (5) : 1157-1162.
[18]	Huggenberger R, Detmar M. The cutaneous vascular system in chronic skin inflammation[J]. Journal of Investigative Dermatology Symposium Proceedings, 2011, 15 (1) : 24-32.
[19]	Jiang W, Zhang H, Xu Y, et al. Cutaneous vessel features of sensitive skin and its underlying functions[J]. Skin Research and Technology, 2020, 26 (3) : 431-437.
[20]	Ойвин И А. 血管通透性的生理学和病理学问题[J]. 周钟鸣, 译. 青岛医学院学报, 1962 (2) : 25.
[21]	Ono S, Egawa G, Kabashima K. Regulation of blood vascular permeability in the skin[J]. Inflammation and Regeneration, 2017, 37: 1-8.
[22]	Koller A, Huang A. Impaired nitric oxide-mediated flow-induced dilation in arterioles of spontaneously hypertensive rats[J]. Circulation Research, 1994, 74 (3) : 416-421.
[23]	Breard M, Sari M A, Frapart Y, et al. The endogenous neurotransmitter, serotonin, modifies neuronal nitric oxide synthase activities[J]. Free Radical Research, 2007, 41 (4) : 413-423.
[24]	Murohara T, Horowitz J R, Silver M, et al. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin[J]. Circulation, 1998, 97 (1) : 99-107.
[25]	Schwenger N, Dux M, Col R, et al. Interaction of calcitonin gene-related peptide, nitric oxide and histamine release in neurogenic blood flow and afferent activation in the rat cranial dura mater[J]. Cephalalgia, 2007, 27 (6) : 481-491.
[26]	Chi Y, Liu X, Chai J. A narrative review of changes in microvascular permeability after burn[J]. Annals of Translational Medicine, 2021, 9 (8).
[27]	Mehta D, Malik A B. Signaling mechanisms regulating endothelial permeability[J]. Physiological Reviews, 2006, 86 (1) : 279-367.
[28]	Bull H A, Hothersall J, Chowdhury N, et al. Neuropeptides induce release of nitric oxide from human dermal microvascular endothelial cells[J]. Journal of Investigative Dermatology, 1996, 106 (4) : 655-660.
[29]	Wilkins B W, Chung L H, Tublitz N J, et al. Mechanisms of vasoactive intestinal peptide-mediated vasodilation in human skin[J]. Journal of Applied Physiology, 2004, 97 (4) : 1291-1298.
[30]	Mehta D, Granstein R D. Immunoregulatory effects of neuropeptides on endothelial cells: relevance to dermatological disorders[J]. Dermatology, 2019, 235 (3) : 175-186.
[31]	Reich A, Orda A, Wiśnicka B, et al. Plasma concentration of selected neuropeptides in patients suffering from psoriasis[J]. Experimental Dermatology, 2007, 16 (5) : 421-428.
[32]	李卫平. 咪唑斯汀治疗慢性荨麻疹219例临床观察[J]. 临床和实验医学杂志, 2010, 9 (19) : 1500.
[33]	Mendes D A G B, da Silva H C D, da Silveira P A, et al. In vivo participation of nitric oxide in hyperproliferative epidermal phenomena in mice[J]. European Journal of Pharmacology, 2012, 687 (1-3) : 1-8.
[34]	Van Aanhold C C L, Bus P, Zandbergen M, et al. The vascular endothelial growth factor inhibitor soluble FLT-1 ameliorates atopic dermatitis in APOC1 transgenic mice[J]. The Journal of Investigative Dermatology, 2020, 140 (2) : 491-494.
[35]	Kim M, Kim K E, Jung H Y, et al. Recombinant erythroid differentiation regulator 1 inhibits both inflammation and angiogenesis in a mouse model of rosacea[J]. Experimental Dermatology, 2015, 24 (9) : 680-685.
[36]	Zhang Y, Matsuo H, Morita E. Increased production of vascular endothelial growth factor in the lesions of atopic dermatitis[J]. Archives of Dermatological Research, 2006, 297: 425-429.
[37]	Xie B, Li X Y. Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1[J]. The Journal of Dermatology, 2019, 46 (3) : 177-185.
[38]	Nykolaichuk K Y, Torous I M. Comparative characteristics of pathogenic features in rosacea and psoriasis (literature review)[J]. Art of Medicine, 2024: 129-132.
[39]	Brain S D, Tippins J R, Morris H R, et al. Potent vasodilator activity of calcitonin gene-related peptide in human skin[J]. Journal of Investigative Dermatology, 1986, 87 (4) : 533-536.
[40]	杨雁, 唐宗湘. 痒觉信号通路与相关受体研究进展[J]. 生物化学与生物物理进展, 2013, 40 (3) : 209-215.
[41]	Tsagareli M G, Follansbee T, Iodi Carstens M, et al. Targeting transient receptor potential (TRP) channels, mas-related g-protein-coupled receptors (Mrgprs), and protease-activated Receptors (PARs) to relieve itch[J]. Pharmaceuticals, 2023, 16 (12) : 1707.
[42]	Liu T, Ji R R. New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?[J]. Pflügers Archiv-European Journal of Physiology, 2013, 465: 1671-1685.
[43]	Basbaum A I, Bautista D M, Scherrer G, et al. Cellular and molecular mechanisms of pain[J]. Cell, 2009, 139 (2) : 267-284.
[44]	Dubin A E, Patapoutian A. Nociceptors: the sensors of the pain pathway[J]. The Journal of Clinical Investigation, 2010, 120 (11) : 3760-3772.
[45]	Soattin L, Fiore M, Gavazzo P, et al. The biophysics of Piezo1 and Piezo2 mechanosensitive channels[J]. Biophysical Chemistry, 2016, 208: 26-33.
[46]	魏娟, 陈旻, 庞颖, 等. 情绪护肤的生理学基础综述[J]. 日用化学品科学, 2024, 47 (6).
[47]	Rosalia Di Gesu. 英敏特2024年美容与个人护理趋势:神形俱美[R]. Mintel Group Ltd., 2024.
[48]	Misery L. Skin, immunity and the nervous system[J]. British Journal of Dermatology, 1997, 137 (6) : 843-850.
[49]	Misery L. Les nerfsàfleur de peau[J]. International Journal of Cosmetic Science, 2002, 24 (2) : 111-116.
[50]	Lugović-Mihić L, Mihatović D, Šitum M. Psychoneuroimmunology and skin diseases[J]. Rad Hrvatske Akademije Znanosti i Umjetnosti. Medicinske Znanosti, 2019 (46-47) : 25-36.
[51]	Slominski A. A nervous breakdown in the skin: stress and the epidermal barrier[J]. The Journal of Clinical Investigation, 2007, 117 (11) : 3166-3169.
[52]	Slominski A T, Slominski R M, Raman C, et al. Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides[J]. American Journal of Physiology-Cell Physiology, 2022, 323 (6) : 1757-1776.
[53]	Wölbing F, Fischer J, Köberle M, et al. About the role and underlying mechanisms of cofactors in anaphylaxis[J]. Allergy, 2013, 68 (9) : 1085-1092.
[54]	Dfarhud D, Malmir M, Khanahmadi M. Happiness & health: the biological factors-systematic review article[J]. Iranian Journal of Public Health, 2014, 43 (11) : 1468.
[55]	Martins A M, Ascenso A, Ribeiro H M, et al. The brain-skin connection and the pathogenesis of psoriasis: a review with a focus on the serotonergic system[J]. Cells, 2020, 9 (4) : 796.
[56]	Vaughn A R, Davis M J, Sivamani R K, et al. A concise review of the conflicting roles of dopamine-1 versus dopamine-2 receptors in wound healing[J]. Molecules, 2017, 23 (1) : 50.
[57]	Ono K, Viet C T, Ye Y, et al. Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling[J]. Scientific Reports, 2017, 7 (1) : 9181.
[58]	Labarrade F, Perrin A, Ferreira Y, et al. Modulation of Piezo1 influences human skin architecture and oxytocin expression[J]. International Journal of Cosmetic Science, 2023, 45 (5) : 604-611.
[59]	Uvnäs-Moberg K, Handlin L. Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation[J]. Frontiers in Psychology, 2015, 5: 116675.

刺激类型	温度/机制	激活受体
热刺激	>42 ℃	TRPV1
	>53 ℃	TRPV2
	25~33 ℃	TRPV3/TRPV4
冷刺激	<15 ℃	TRPM8（<10~15 ℃）、TRPA1（<17 ℃）
机械刺激	牵张、压缩、剪切力等	TRPV4、ASIC、Piezo1/Piezo2
化学刺激	1）微生物；2）炎症介质：前列腺（PGE2、PGI2）、神经营养因（NGF）、神经肽（SP、CGRP）；3）非炎症介质：GABA、阿片肽、大麻素	TRP家族（如TRPV1、TRPA1）、TOLL受体