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China Surfactant Detergent & Cosmetics ›› 2016, Vol. 46 ›› Issue (8): 473-478.doi: 10.13218/j.cnki.csdc.2016.08.010

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Adverse Outcome Pathways Guide and toxicity test applications

QU Xiao-ting1,CHENG Shu-jun2,QIN Yao3,KE Yi-hui2   

  1. 1.Humane Society International,Washington D.C. 20037,America;
    2.Guangdong Inspection and Quarantine Technology Center, Guangzhou,Guangdong 510623,China;
    3.Guangzhou Chn-Alt Biotech.Ltd.,Guangzhou,Guangdong 510623,China
  • Online:2016-08-22 Published:2019-04-18

Abstract: The arising and development of Adverse Outcome Pathways (AOP) under the advocation of toxicity test vision and strategy in the 21st century as well as the pressure of regulation system changes and development of modern science and technology were reviewed.The concept and guide of AOP;the basic composition,structural conditions and information sharing of AOP as well as network and assessment of AOP were emphatically introduced.The development and application situation in two toxicity endpoints,the skin sensitization test and fish early-growth stage test were discussed as the practice instances of different AOP development strategy that is top-down approach and middle-out approach.Finally,it was concluded that the AOP relies on the development of modern science and technology as the driving force,toxicity prediction modernization as the basis,regulation mode change as the target.AOP guideline also provides an opportunity for the development of alternatives to animal testing method and testing technology innovation.

Key words: Adverse Outcome Pathways, alternative method, toxicity testing, guide, chemicals

CLC Number: 

  • R114