Abstract:

The lipidomics method was used to systematically analyze the difference in lipid composition of black and white hair between early white hair and physiological white hair females, and the relationship between lipid composition and age of female white hair follicle. The aim of the study was to prevent female white hair in different age stages, and to provide new ideas of the research and development of lipid added hair product. UPLC-QTOF-MS combined with OPLS-DA （orthogonal partial least squares discriminant analysis） model was used to analyze the difference of hair follicle lipids in different samples. There were significant differences in the contents of glycerol diester （DG） and phosphatidylserine （PS） between black hair （Y-B） and white hair （Y-W）. The content of PS in Y-W was higher than that in Y-B, while that in DG was on the contrary. In physiological white hair, the difference of PS between black hair （O-B） and white hair （O-W） was the most significant, followed by triglyceride （TG）, and the content of O-W was higher than that of O-B. In physiological white hair （O-W） and early white hair （Y-W）, the difference of PS content was the most significant, and the content of O-W was higher than that of Y-W. The results showed that the content of PS in white hair was higher than that in black hair, and the content of physiological white hair was higher than that in early white hair. It was speculated that the increase of PS may be related to the occurrence of white hair; DG had a greater impact on early gray hair, while TG had a greater impact on physiological white hair, which had certain reference significance for the research and development of targeted lipid-added hair products.

Key words: female, polymeric lipid, early white hair, physiological white hair, ultra high performance liquid chromatography-tandem time-of-flight mass spectrometry, hair product