EGCG类脂质体及其冷冻解冻凝胶的制备与表征

doi:10.3969/j.issn.1001-1803.2019.06.003

Abstract

Abstract:

EGCG-loaded niosomes（EN）were prepared by ethanol injection method using Tween 60 and cholesterol as encapsulation materials. The effects of hydration methods and hydration media on the particle size, PDI, entrapment efficiency and loading capacity of EN were studied. The results showed that, when deionized water was used as hydration medium, the EN prepared at 12 000 r/min for 1 min had small particle size of 61.4 nm and a PDI of 0.189±0.020. High entrapment efficiency and loading capacity were achieved as 79.4% and 7.97%, respectively. The PVA/HA/EN cryogels were prepared by embedding EN into PVA/HA cryogels by freeze-thaw method. SEM characterization showed that the presence of EN in PVA/HA cryogels resulted in a porous structure, and EN was not damaged and kept the original particle size. Through the study on the release rate of PVA/HA/EN cryogels, it was found that PVA/HA/EN cryogels had better sustained release effects than the PVA/HA/ES cryogels which directly loaded with EGCG, when the EGCG concentration was the same.

Key words: EGCG-loaded niosomes, cryogel, preparation, release

CLC Number:

TQ423.2

SUN Xiang,LIANG Rong,YANG Cheng. Preparation and characterization of the EGCG-loaded niosome and its cryogel[J].China Surfactant Detergent & Cosmetics, 2019, 49(6): 363-368.

Figures/Tables 7

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References 19

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Preparation and characterization of the EGCG-loaded niosome and its cryogel

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