聚氧化乙烯/海藻酸钠/羟丙基-癸烷基壳聚糖网络凝胶的制备及其对三七总皂苷的体外释放性能研究

doi:10.13218/j.cnki.csdc.2018.04.005

Abstract

Abstract: Amphiphilic hydroxypropyl-decyl chitosan was prepared by modification of chitosan.The drug-loading network gel of polyethylene oxide/sodium alginate/hydroxypropyl-decyl chitosan (PEO/SA/HP-DCCS) were prepared via chemical cross-linking method.The structure of the gel was characterized by FT-IR,XRD and SEM.Results show that this gel has good network structure and swelling property toghether with sensitiveness to pH and temperature.The gel has sustained-release effect on panax notoginseng saponins at different pH values.

Key words: hydroxypropyl-decyl chitosan, sodium alginate, polyethylene oxide, gel, panax notoginseng saponins

CLC Number:

O635

TAN Fu-neng. Preparation of network gel of polyethylene oxide/sodium alginate/hydroxypropyl-decyl chitosan and its behavior for in vitro release of panax notoginseng saponins[J].China Surfactant Detergent & Cosmetics, 2018, 48(4): 205-209.

References

[1] Jiang Tingda.Chitin [M].Beijing:Chemical Industry Press,2003:12.
[2] Yao Risheng,Polymers in pharmaceutics [M].Beijing:Chemical Industry Press,2003:16.
[3] Muxika A,Etxabide A,Uranga J,et al.Chitosan as a bioactive polymer:Processing,properties and applications [J].Int.J.Biol.Macromol.,2017,105(2):1358-1368.
[4] Patrulea V,Ostafe V,Borchard G,et al.Chitosan as a starting material for wound healing applications [J].Eur.J.Pharm.Biopharm.,2015,97:417-426.
[5] Choi C Y,Nam J P,Nah J W,et al.Application of chitosan and chitosan derivatives as biomaterials Review article [J].J.Ind.Eng.Chem.,2016,35(25):1-10.
[6] Pedro R O,Carla C S,Miguel G,et al.Syntheses and characterization of amphiphilic quaternary ammonium chitosan derivatives [J].Carbohydrate Polymers,2016,147(20):97-103.
[7] Lin Y H,Liang H F,Chung C K,et al.A non-covalently cross-linked chitosan based hydrogel [J].Biomaterials,2005,26:2105-2113.
[8] Dewan M,Bhowmick B,Sarkar G,et al.Effect of methyl cellulose on gelation behavior and drug release from poloxamer based ophthalmic formulations[J].Int.J.Biol.Macromol.,2015,72:706-710.
[9] Jalalvandi E,Cabral J,Hanton L R,et al.Cyclodextrin-polyhydrazine degradable gels for hydrophobic drug delivery [J].Mater.Sci.Eng.C,2016,69(11):144-153.
[10] Yom-Tov O,Seliktar D,Bianco-Peled H.A modified emulsion gelation technique to improve buoyancy of hydrogel tablets for floating drug delivery systems [J].Mater.Sci.Eng.C,2015,55(1):335-342.
[11] Guo Jintang,Li Xiongyong,Li Ling.Hydrogels and its application in drug controlled release [J].Chemistry Bulletin,2004,67 (3):198-203.
[12] Tian Z H,Pang H H,Du S Y,et al.Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats [J].J.Chromato.B,2017,1040(1):136-143.
[13] Wang P P,Cui J G,Du X Y,et al.Panax notoginseng saponins (PNS) inhibits breast cancer metastasis [J].J.Ethnopharmacology,2014,154(3):663-671.
[14] Wang M M,Xue M,Xu Y G,et al.Panax notoginseng saponin is superior to aspirin in inhibiting platelet adhesion to injured endothelial cells through COX pathway in vitro [J].Thrombosis Research,2016,141:146-152.
[15] Deng Chunli,Luo Jieqi,Sha Xianyi,et al.Pharmacokinetic and pharmacodynamic study of Panax notoginseng saponins na-sal gel spray [J].Chinese Journal of Clinical Pharmacy,2014,23(5):276-282.
[16] Tan Funeng,Sui Weiping.Preparation and surface properties of O-hydroxypropyl-N-laurel acyl chitosan [J].China Surfactant Detergent ＆ Cosmetics,2015,45(5):252-256.
[17] Zheng Shishi,Wang Zengshou.Preparation and in vitro drug release of carboxymethyl chitosan pH-sensitive hydrogels [J].China Pharmacist,2013,16(4):534-536.

Preparation of network gel of polyethylene oxide/sodium alginate/hydroxypropyl-decyl chitosan and its behavior for in vitro release of panax notoginseng saponins

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