神经酰胺ⅢB纳米脂质体的制备及功效评价

doi:10.13218/j.cnki.csdc.2016.09.006

Abstract

Abstract: Ceramide ⅢB nanoliposome was prepared by high pressure homogenization technique.Properties of the product were measured as particle size,71.7 nm;PDI,0.214;Zeta potential,-23.3 mV;rate of drug loading,2.3%;rate of encapsulation,95.9%.The in vitro skin permeation and retention tests were performed with Franz diffusion cell method.Results showed that the cumulative permeation and skin retention in 24 h was 709.23 and 75.07 μg/cm²,respectively.The skin retention of ceramide ⅢB nanoliposome cream product in 24 h was 6 times higher than that of conventional ceramide ⅢB cream product with the same mass fraction.The experiment was continued for 40 d on mouse skin and the results demonstrated that ceramide ⅢB nanoliposome exhibits a significant epidermal hydration capacity and total ceramides mass concentration as comparing with that of the control test group.

Key words: additives of cosmetics, ceramide ⅢB, nanoliposomeefficacy evaluation

CLC Number:

TQ658

LI Xia,TIAN Ren-de,XU Qi,GUO Feng-feng,LIU Wei. Preparation and efficacy evaluation of ceramide ⅢB nanoliposome[J].China Surfactant Detergent & Cosmetics, 2016, 46(9): 514-518.

References

[1] MOJUMDAR E H,GOORIS G S,BARLOW D J,et al.Skin lipids:Localization of ceramide and fatty acid in the unit cell of the long perio-dicity phase [J].Biophysical Journal,2015,108(11):2670-2679.
[2] SONDARI D,HARYONO A,HARMAMI S B,et al.Influence of palmitoyl pentapeptide and Ceramide ⅢB on the droplet size of nanoemulsion [C].Conference on Southeast Asian International Advances in Micro/Nanotechnology,Proc of SPIE,2010,Vol.7743 77430D-1-7.
[3] 郑琪瑶,王士斌,刘源岗.含有神经酰胺脂质体的研究进展[J].日用化学工业,2011,41(1):50-54.
[4] YILMAZ E,BORCHER H H.Design of a phytosphingosine-containing,positively-charged nanoemulsion as a colloidal carrier system for dermal application of ceramides [J].European Journal of Pharmaceutics and Biopharmaceutics,2005(60):91-98.
[5] 柯学,王长江,严菲.滤膜法测定多西紫杉醇脂质体的包封率[J].中国现代应用药学,2008,25(4):314-316.
[6] 全国香料香精化妆品标准化技术委员会.润肤膏霜:QB/T 1857-2013 [S].北京:中国标准出版社,2013.
[7] DRAGICEVIC-CURIC N,GRAEFE S,GITTER B,et al.Surface charged temoporfin-loaded flexible vesicles:in vitro skin penetration studies and stability [J].International Journal of Pharmaceutics,2010,384(1):100-108.
[8] 全国香料香精化妆品标准化技术委员会.化妆品保湿功效评价指南:QB/T 4256-2011 [S].北京:中国标准出版社,2011.
[9] 李芳梅.当归饮子对寻常型银屑病皮肤屏障功能影响的研究[D].长沙:湖南中医药大学,2014.
[10] 翁晓芳,高红军,林统文,等.皮肤屏障功能研究及其在化妆品中的应用[J].广东化工,2015,42(4):61-63.
[11] CHAMLIN S L,FRIEDEN I J,FOWLER A,et al.Ceramide-dominant,barrier repair lipids improve childhood atopic dermatitis [J].Arch Dermatol,2001,137(8):1110-1112.

Preparation and efficacy evaluation of ceramide ⅢB nanoliposome

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 6

Metrics

Comments

Recommended 10

[1]	Song Guanjie,Wu Wenhai,Zhang Huirong,Wu Yuehang,Yi Fan,Li Li. Preparation and evaluation of ceramide ⅢB phospholipid complex [J]. China Surfactant Detergent & Cosmetics, 2023, 53(2): 149-156.
[2]	GUO Xiao-dan,SONG Jing-jiu,ZHU Jun. Synthesis and anti-oxidant activity of feruloylamino acid ethyl ester [J]. China Surfactant Detergent & Cosmetics, 2020, 50(9): 624-628.
[3]	HE Gai-ying,CHEN Di,SHEN Li. The effect of Chinese herbal anti-acne formula on pathogenic bacteria and exocrine enzyme of acne vulgaris [J]. China Surfactant Detergent & Cosmetics, 2018, 48(7): 403-407.
[4]	LIANG Rong,WU Li-na,YANG Cheng,QIAN Xin,CAO Guang-qun. Application of co-enzyme Q10-loaded nanostructured lipid carriers in cosmetics [J]. China Surfactant Detergent & Cosmetics, 2016, 46(9): 524-529.
[5]	CHEN Mo,ZHAO Ya,SUN Yi. Action of Eucommia ulmoides extract for prevention of photo-aging damage of human skin fibroblast cells induced by UVB and exploration of its mechanism at genetic level [J]. China Surfactant Detergent & Cosmetics, 2016, 46(1): 35-38.
[6]	KONG Ling-shan, YU Ling, HU Guo-sheng, CUI Shu-mei, WANG Yi-li. Molecular weight,hygroscopicity and moisturizing performance of polysaccharide from Rhizoma Bletillae [J]. China Surfactant Detergent & Cosmetics, 2015, 45(2): 94-98.