Abstract: Pseudo solution of hesperetin micelle was prepared,and influence of hyaluronic acid on its stability and percutaneous osmosis activity was investigated using Zeta potential and percutaneous osmosis rate as the respective indices.Experimental results showed that hyaluronic acid can significantly enhance the stability and percutaneous osmosis activity of hesperetin micelle pseudo solution.When the mass fraction of hyaluronic acid achieves 0.5%,the micelle pseudo solution becomes transparent,stable and without unpleasant odor.Under room temperature condition,its average pH value is 5.4±0.1 and average Zeta potential is -32.62 mV.The steady osmosis rate constant J_s of hesperetin through cavy skin achieves 7.475 8 μg/(cm²·h),which is 1.5 multiples as compared with that of the control group.The micelle pseudo solution shows good stability in cold resistance test and heat resistance test.

Key words: skin care cosmetic additives, hesperetin, micelle, hyaluronic acid, stability, percutaneous osmosis activity