杜仲预防UVB致人成纤维细胞光老化的作用及基因水平的机制探讨

doi:10.13218/j.cnki.csdc.2016.01.007

Abstract

Abstract: Based upon test with irradiation of UVB on human skin fibroblast cells (HSFs) cultivated in vitro,the action of ethyl acetate extract from ethanol extract of Eucommia ulmoides (hereinafter refers to as the Eucommia ulmoides extract) for prevention of photo-aging damage of HSFs was explored;and its possible action mechanism was searched by utilizing cDNA microarray.Experimental results showed that the Eucommia ulmoides extract can reduce the effect of UVB on the HSBs and displays rather good action for preventing photo-aging damage.Further,the cDNA microarray test results demonstrated that possibly,such prevention action may correlates with the enhancement of antioxidation capacity of the HSFs,the DNA repairing system,and the capacity for suppression of apoptosis.Meanwhile,it may have the action for promoting cell proliferation and preventing the growth of melanoma.

Key words: additives of cosmetics, Eucommia ulmoides, photo-aging, UVB, cDNA microarray

CLC Number:

TQ658

CHEN Mo,ZHAO Ya,SUN Yi. Action of Eucommia ulmoides extract for prevention of photo-aging damage of human skin fibroblast cells induced by UVB and exploration of its mechanism at genetic level[J].China Surfactant Detergent & Cosmetics, 2016, 46(1): 35-38.

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Action of Eucommia ulmoides extract for prevention of photo-aging damage of human skin fibroblast cells induced by UVB and exploration of its mechanism at genetic level

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