Fig. 1

Technology flow diagram of the human efficacy evaluation test"

Tab. 1

Instrument measurement index"

Tab. 2

Melanin index （MI）, erythema index （EI）, skin brightness L*, skin color ITA°, and gloss value in the dark circles’ area at each time point of measurement"

Fig. 2

Example of improvement of dark circles （Visia CR images, female, 38 years old）"

Fig. 3

Skin elasticity （a） and dermal thickness （b） at each time point of measurement （Positive change （%） indicates skin improvement; P<0.05 indicates a significant difference compared to week 0）"

Tab. 3

The under-eye wrinkle parameter results"

Fig. 4

Example of improvement of fine wrinkles under eyes （Primos CR standardized grayscale images and color height maps in the skin under the eyes, female, 37 years old; The color height map shows depressions in blue-green and bumps in red-yellow）"

Tab. 4

The crow’s feet parameter results"

Fig. 5

Example of improvement of crow’s feet （Primos CR standardized grayscale images and color height maps in the skin under the eyes, female, 40 years old; The color height map shows depressions in blue-green and bumps in red-yellow）"

Fig. 6

The under-eye bags volume at each time point of measurement （Negative change （%） indicates an improvement in under-eyebags; P<0.05 indicates a significant difference compared to week 0）"

Fig. 7

Example of improvement of the under-eye bags （Primos CR standardized grayscale images, female, 40 years old）"

Fig. 8

Dermatologist evaluation results （All assessment data were significantly different compared to week 0, P<0.05. Rating scale: 0-9 scores, the smaller the score the better the skin）"

Fig. 9

Subject questionnaire results （All assessment data were significantly different compared to week 0, P<0.05. Rating scale: 0-9 scores, the smaller the score the better the skin）"

Tab. 5

Correlation analysis of dermatologist assessments, instrumental tests/subject self-assessment results for dark circles and eye bags"