防晒类化妆品中二氧化钛纳米颗粒的筛查方法研究

doi:10.3969/j.issn.2097-2806.2025.04.004

Abstract

Abstract:

A method was developed for the determination of particle size and distribution of titanium dioxide nanoparticles in sunscreen using single particle-inductively coupled plasma-mass spectrometry （spICP-MS）. The titanium dioxide nanoparticles were characterized by high resolution transmission electron microscopy （HRTEM） and energy dispersive spectroscopy （EDS）. 0.1% Triton X-100 was employed as an extractant for ultrasound-assisted extraction of titanium dioxide nanoparticles in cosmetics. The data were acquired in pulse signal mode, and the particle size and distribution were determined through calculation. The experimental results demonstrate that the lower limit of particle size detection is influenced not only by the background signal of the isotope to be detected but also by the cosmetic matrix. Different background thresholds significantly affect both the lower limit of particle size detection and the number of identified particles, thereby directly impacting compliance and safety considerations for cosmetics. This method enables rapid screening of titanium dioxide nanoparticles in sunscreen cosmetics while simultaneously determining and characterizing their particle size and distribution, providing a framework for discussing compliance and safety investigations regarding nanoparticle-containing cosmetics.

Key words: single particle inductively coupled plasma mass spectrometry （spICP-MS）, titanium dioxide nanoparticle （TiO₂-NP）, threshold criterion, sunscreen

CLC Number:

O657.63

Shuo Li, Jing Dai, Qingwu Li, Li Li. Research on screening methods for TiO₂ nanoparticles in sunscreen cosmetics[J].China Surfactant Detergent & Cosmetics, 2025, 55(4): 430-436.

Figures/Tables 8

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阈值	检测限/nm	平均值/nm	中位值/nm	颗粒浓度（颗粒个数×10⁹/g）
3σ	63	71	67	3.6
4σ	70	80	75	1.3
5σ	76	90	82	0.56
7σ	85	106	100	0.22

Research on screening methods for TiO₂ nanoparticles in sunscreen cosmetics

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Research on screening methods for TiO2 nanoparticles in sunscreen cosmetics

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Research on screening methods for TiO₂ nanoparticles in sunscreen cosmetics