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China Surfactant Detergent & Cosmetics ›› 2024, Vol. 54 ›› Issue (2): 188-195.doi: 10.3969/j.issn.2097-2806.2024.02.010

• Development and application • Previous Articles     Next Articles

Study on the inhibitory effect of total glycosides of Paeonia veitchii and its main component paeoniflorin on acne-associated inflammation

Weilan Liu1,Li Li1,Chunnian He2,Yinmao Dong1,Xiao Ling3,Miaomiao Guo1,*()   

  1. 1. Beijing Key Laboratory of Plant Research and Development, Beijing Technology and Business University, Beijing 100048, China
    2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    3. Beijing Lan Divine Technology Co. LTD, Beijing 100081, China
  • Received:2023-02-10 Revised:2024-01-30 Online:2024-02-22 Published:2024-02-28
  • Contact: * Tel.: +86-10-68984949, E-mail: guomiaomiao@btbu.edu.cn.

Abstract:

In this study, the anti-inflammatory capacity of total paeoniflorin was evaluated by establishing an inflammatory model of Cropionibacterium acnesC.acnes)-induced THP-1 cells and exploring its main active components for anti-inflammation. The results show that at a concentration of 100 μg/mL, the root extract of Paeonia veitchii significantly inhibits the inflammatory factors IL-1β and IL-8 induced by C.acnesp<0.01). Total glucoside of Paeonia veitchii from the root extract of Paeonia veitchii increases the inhibition rate of inflammatory factor IL-1β by 20% at the same concentration. The contents of albiflorin, paeoniflorin and benzoyl paeoniflorin in the total glucoside of Paeonia veitchii are 0.64%, 26.3% and 1.17%, respectively. Among them, paeoniflorin has the highest content and the most significant inhibition of inflammatory factor IL-1β induced by C.acnes. In addition, paeoniflorin reduces the reactive oxygen species and lactate dehydrogenase induced by C.acnes. In conclusion, the total glucoside extract of Paeonia veitchii and its main active ingredient paeoniflorin have potential therapeutic value in improving the skin inflammation caused by C.acnes.

Key words: acne, total glucoside of Paeonia veitchii, paeoniflorin, anti-inflammatory

CLC Number: 

  • TQ658