一款紧致化妆品的功效评价方法研究

doi:10.3969/j.issn.2097-2806.2024.01.010

Abstract

Abstract:

By evaluating the efficacy of a cosmetics with palmitoyl pentapeptide-4 as the main functional ingredient, the study establishes a clinical evaluation method system for firming efficacy. Thirty-one female subjects aged 20-50 were screened, and the skin indexes including the objective test data, image methods and subject self-assessment methods were evaluated after using the product for 0 week, 4 weeks and 8 weeks, respectively. The parameters of skin elasticity and skin dermal density in the cheeks and canthus of the subjects, as well as the TPEF images and the SHG images, were captured, and comparative analyses were carried out. The results show significant changes in skin elasticity, dermal density （P<0.001） and DEJI （P<0.01） after 8 weeks, which are consistent with the results of the subjects’ self-ratings, indicating a correlation between the methods. This research can provide technical supports for the establishment of a cosmetic firming efficacy evaluation method system.

Key words: elasticity, firmness, two-photon imaging technology, ultrasound, evaluation of cosmetic efficacy, elastin fibres, collagen fibres

CLC Number:

TQ658

Yueying Ma, Qi Liu, Meng Jia, Junjie Wang, Wei Wang, Hua Zhao. A study on the method of evaluating the efficacy of a firming cosmetic[J].China Surfactant Detergent & Cosmetics, 2024, 54(1): 73-79.

Figures/Tables 14

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References 22

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相	组分名称	w/%
A相	去离子水	To 100
	丁二醇	3
	甘油	5
	黄原胶	0.1
	AVC	0.5
	透明质酸	0.05
	泛醇	0.5
B相	异十六烷	3
	异硬脂酸异丙酯	2
	聚二甲基硅氧烷	3
	牛油果树果脂	1.5
	A165（甘油硬脂酸酯和PEG-100硬脂酸脂）	2
	生育酚乙酸酯	0.2
	鲸蜡硬脂醇	2
C相	棕榈酰五肽-4	2
	戊二醇	4
	香精	0.05

标准	标准细则
纳入标准	年龄在20~50岁之间的女性;
纳入标准	测试期间不进行影响结果的活动
排除标准	妊娠或哺乳期妇女，或近期有备孕计划;
	免疫缺陷或自身免疫性疾病患者或胰岛素依赖性糖尿病患者，或体质高度敏感者;
	对化妆品有过敏或高度敏感风险者;
	近半年内做过抗衰类光电项目;
	近一周使用抗组胺药或近一个月内使用免疫抑制剂;
	近1个月内参加过化妆品人体临床试验;
	患有过敏性皮炎、脂溢性皮炎、湿疹和酒渣鼻等皮肤病的志愿者;
	每天暴露在阳光下3~6 h;
	其他临床评估认为不适合参加试验者;
	非志愿参加或不能按试验要求完成规定内容者

测试指标	时间对比	人数/例	统计方法	显著性	P值
眼角DEJI	第0周与第4周	31	配对样本T检验	n.s	0.447
眼角DEJI	第0周与第8周	31	配对样本T检验	**	0.001

A study on the method of evaluating the efficacy of a firming cosmetic

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