Abstract:

In recent years, the research on hair loss has become more and more intensive. In this work, acetyl tetrapeptide-11 was applied in mice to study its effect on hair loss. After depilation treatment on the back of eight C57BL/6 female mice, the experimental group was continually smeared with aqueous solutions of acetyl tetrapeptide-11 with different mass concentrations （10, 20 and 30 μg/mL） for 18 days, while the control group was smeared with normal saline. The hair growth on the back of mice was observed, and HE staining was used for histological analysis. The efficacy on human volunteers was also preliminarily evaluated. The results on mice showed that a certain mass concentration of acetyl tetrapeptide-11 could prevent hair loss and avoid the miniaturization of hair follicles and maintain epidermis firmness. The results on human volunteers showed that, the test samples had prevention effect on hair loss for all volunteers, and 85% of the volunteers gave feedback to denser hair. This study could provide a new solution and theoretical basis for hair loss prevention.

Key words: acetyl tetrapeptide-11, ⅩⅤⅡ collagen, hair loss, follicle stem cell