油酸在氢氧化胆碱水溶液中的自组装及十二烷基硫酸钠对其囊泡化pH窗口的影响

doi:10.3969/j.issn.2097-2806.2023.09.004

Abstract

Abstract:

Fatty acid vesicles have closed bilayer structure and can encapsulate active molecules. Taking oleic acid （OA） as model fatty acid, the phase regions including micelles, vesicles, emulsion and oil-water separation were designated using pH titration curve and visual observation method. The pH window of OA/hydroxide choline （ChOH） vesicles was determined to be 7.5-9.1. The size and morphology of OA/ChOH vesicles were characterized using dynamic light scattering, phase contrast microscopy and transmission electron microscopy, showing size polydispersity. An anionic surfactant, sodium dodecyl sulfate （SDS）, was added to OA/ChOH system, aiming to shift and expand the pH window of OA/ChOH vesicles to a range from being acidic to slightly alkaline, depending on the molar ratio （x） of SDS. At x=0.1, the pH window could be shifted to lower pH which matched the pH range of body fluid. With increasing x, the pH window was significantly broadened towards acidity, even reaching a very low pH of 1.3. The hydrogen bonding between SDS and OA molecules played a key role in the vesicle formation in the lower pH range, which had replaced the hydrogen bonding between acid-soap dimers of fatty acids. The composite vesicles as capsules had higher encapsulation efficiency, drug-loading capacity, and sustained drug release properties. This research work could provide a theoretical guidance for potential application in drug delivery and cosmetics.

Key words: oleic acid, choline hydroxide, sodium dodecyl sulfate, fatty acid vesicle, pH window

CLC Number:

TQ423

Liang Xin, Xu Huifang, Lu Song, Li Yuanyuan, Wang Sijia, Xie Caixia. Self-assembly of oleic acid in aqueous solution of choline hydroxide and effects of sodium dodecyl sulfate on the pH window thereof for vesicle formation[J].China Surfactant Detergent & Cosmetics, 2023, 53(9): 1018-1028.

Figures/Tables 12

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References 35

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x	pH Window
x	Range	Width
0	7.5~9.1	1.6
0.05	7.4~9.0	1.6
0.1	6.9~8.6	1.7
0.2	6.6~8.2	1.6
0.3	6.1~8.3 1.1~1.7	2.2 0.6
0.4	1.5~7.9	6.4
0.5	1.3~8.2	6.9

Self-assembly of oleic acid in aqueous solution of choline hydroxide and effects of sodium dodecyl sulfate on the pH window thereof for vesicle formation

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