Abstract:

Motherwort （Leonurus japonicas Houtt.） is a good gynecological medicine, which has the function of promoting circulation of blood, nourishing blood and activating circulation to remove blood stasis. It is widely used in clinical practice and commonly used to treat gynecological diseases, while the beauty application of motherwort has gradually attracted attention in recent year. This article built an in silico technology platform to present a systematic review of the literature concerning motherwort over the past two decades through bibliometrics to explore current research hotspots and predict the future development trends, and combine with network pharmacology to predict the efficacy and material basis of motherwort for skin beauty. The results show that terpenoids and alkali, the main active ingredient of motherwort, can effectively open blood vessles and expand blood passages to improve the facial skin blood micro-circulation and strengthen the skin's metabolism through NADPH, PDPK1, MAOB, VEGF2, SIRT2. In addition, they can regulate hormone metabolism to maintain the skin barrier, regulate the secretion of inflammatory factors to ease skin inflammation and involve in the regulation of cell-cycle to prevents oxidative stress-mediated skin aging by ER-α,ER-β, AKRAC3, CA2, HSP90AA1, MAPK14, CDK2 and other targets. Our research suggests that motherwort has the effect of delaying skin aging and nourishing skin. This study provides the theoretical basis for the material basis and efficacy mechanism of motherwort as a cosmetic plant efficacy raw material, and proves the uniqueness of motherwort as a cosmetic efficacy raw material, and has good development prospects.

Key words: Leonurus japonicus, cosmetics, skin health, in silico, bibliometrics, network pharmacology