Abstract:

Based on a SLS-induced 3D epidermal skin injury model （EpiKutis^®）, the effect of stearyl glycyrrhetinate （SG） at 10 μg/mL, 500 μg/mL, 1 mg/mL, and 2 mg/mL was studied comparing with the control group. The tissue morphology is improved at the four mass concentrations and the secretion of IL-1α, TNF-α and PGE2 are significantly decreased. The final results show that the inhibition rates of IL-1α are 26.31%, 30.23%, 36.30%, and 52.55%, respectively. The inhibition rates of TNF-α are 11.50%, 22.47%, 25.71%, and 46.73%, respectively. The inhibition rates of PGE2 are 28.31%, 31.51%, 45.32%, and 57.28%, respectively. It is believed that SG achieves a soothing effect by improving tissue morphology and inhibiting the secretion of IL-1α, TNF-α and PGE2. And the down-regulation effect of SG on IL-1α is significantly better than the 15.20% inhibition rate of 100 μg/mL dexamethasone under the conditions of four experimental concentrations. In the test, SG shows excellent anti-inflammatory and soothing function.

Key words: stearyl glycyrrhizinate, in vitro efficacy evaluation, anti-allergic, soothing, inflammatory factors