P/O/LC/W多重乳状液的制备及性能研究

doi:10.3969/j.issn.1001-1803.2023.02.001

Abstract

Abstract:

A type of polyol-in-oil-in-liquid crystal-in-water （P/O/LC/W） multiple emulsion was prepared by two-step method with liquid crystal emulsifier and traditional emulsifier. The samples were characterized by microscopy. The effects of different liquid crystal emulsifiers, emulsification temperature and homogenization rate on the microstructure of P/O/LC/W multiple emulsion were studied. The steps of preparation process were as follows: The emulsification temperature was 60-75 ℃; the homogenization rate of polyol in oil was 7 000-8 400 r/min and homogenization time was ~6 min; the homogenization rate of polyol in oil in liquid crystal in water was 4 400-6 000 r/min and homogenization time was ~7 min. The emulsion was put at room temperature for 28 days, and multiple structures and liquid crystal structures could still be observed, and the liquid crystal became brighter. The components of the formula were glycerol （polyol phase）, squalane （oil phase）, P135 （hydrophobic emulsifier）, and IST-LC001 （liquid crystal emulsifier）. The ideal emulsion structure could thus be obtained. The formula was used to encapsulate active substances. Resveratrol was used as the target molecule for sustained-release experiment. The results of dialysis experiments in vitro showed that the P/O/LC/W multiple emulsion had a remarkable slow-release performance. The release ratio of target molecule was up to 83% after 10 h. When shikonin was used as the target molecule, it was proved that the P/O/LC/W multiple emulsion could mask the color of the target molecule. Compared with traditional emulsion, the color of P/O/LC/W multiple emulsion was lighter. Rheological measurement showed that the viscosity of the emulsion decreased with the increase of shear stress, indicative of positive thixotropy. Within the investigated range, the storage modulus of the emulsion was always higher than that of loss modulus, exhibiting elastic properties. The internal structure of the emulsion was stable and the emulsion could bring good skin feel to skin care products. The experimental results showed that, the P/O/LC/W multiple emulsion could not only solve the problems in application of insoluble functional ingredients in formulations, but also effectively deliver these active substances and achieve slow-release. The emulsion could also mask the color of introduced ingredients and improve the skin feel of products. The P/O/LC/W multiple emulsion has wide application value in the fields of medicine, food, cosmetics, etc.

Key words: multiple emulsion, lamellar liquid crystal emulsion, polyol, slow release

CLC Number:

O648.23

Lv Yawen,Wang Jingwen,Ye Zhicheng,Shang Yazhuo,Liu Honglai. Preparation of P/O/LC/W multiple emulsion[J].China Surfactant Detergent & Cosmetics, 2023, 53(2): 121-132.

Figures/Tables 18

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References 26

[1]	Rajinder P. Viscosity models for multiple emulsions[J]. Food Hydrocolloids, 2006, 22 (3):428-438. doi: 10.1016/j.foodhyd.2006.12.012
[2]	Rajinder P. Rheology of simple and multiple emulsions[J]. Current Opinion in Colloid & Interface Science, 2010, 16 (1):41-60. doi: 10.1016/j.cocis.2010.10.001
[3]	Garti N. Progress in stabilization and transport phenomena of double emulsions in food applications[J]. LWT - Food Science and Technology, 1997, 30 (3):222-235. doi: 10.1006/fstl.1996.0176
[4]	Luo Shaoiang, Zhang Chen, Hu Liuyun, et al. Stability and rheology of three types of W/O/W multiple emulsions emulsified with lecithin[J]. Journal of Dispersion Science and Technology, 2017, 38 (11):1530-1535. doi: 10.1080/01932691.2016.1259074
[5]	Luo Shaoiang, Zhang Chen, Wen Jing, et al. Progress in research work with respect to multiple structures applied in encapsulation technology[J]. China Surfactant Detergent & Cosmetics, 2016, 46 (12):723-728.
[6]	Zhu Dan, Wu Shenwei, Zhang Weijie, et al. Preparation of polyols in oil in water multiple emulsions containing Vitamin C[J]. Chemical World, 2019, 60 (4):227-235.
[7]	Wen Xiaofang, Liu Dehai, Zhang Weijie, et al. The research of a natural liquid crystal emulsification in lotion[J]. Guangdong Chemical Industry, 2015, 42 (16):67-69, 4.
[8]	Wang Ye, Li Jiusheng, Shang Yazhuo, et al. Study on the development of wax emulsion with liquid crystal structure and its moisturizing and frictional interactions with skin[J]. Colloids and Surfaces B: Biointerfaces, 2018, 171: 335-342. doi: S0927-7765(18)30487-9 pmid: 30055474
[9]	Savi S D, Savi M M, Vesi S A, et al. Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation[J]. International Journal of Pharmaceutics, 2006, 320 (1/2):86-95. doi: 10.1016/j.ijpharm.2006.04.019
[10]	Fang Yun, Shen Xiaoqin, Lu Jie, et al. Influence of co-emulsifier on stability and liquid crystal status of cosmetic emulsion[J]. China Surfactant Detergent & Cosmetics, 2002 (1):8-11.
[11]	L S Calixto, P M B G Maia Campos. Physical-Mechanical characterization of cosmetic formulations and correlation between instrumental measurements and sensorial properties[J]. International Journal of Cosmetic Science, 2017, 39 (5):527-534. doi: 10.1111/ics.12406 pmid: 28555924
[12]	Liu Y, Friberg S E. Role of liquid crystal in the emulsification of a gel emulsion with high internal phase fraction[J]. Journal of Colloid & Interface Science, 2009, 340 (2):261-268.
[13]	Yuan Wenjia. Understanding of the formation of ordered liquid crystal structure from the perspective of thermodynamics[J]. Guangdong Chemical Industry, 2021, 48 (8):149-151.
[14]	Jia Bing, Zhang Qianjie, Zhang Zheng, et al. Preparation of liquid crystal emulsion and its application performance study[J]. Journal of Dispersion Science and Technology, 2018, 39 (1):100-105. doi: 10.1080/01932691.2017.1297721
[15]	Zhou Meng. Development and application of high efficiency compound liquid crystal emulsifier[D]. Shanghai: East China University of Science and Technology, 2018.
[16]	Yuan Minjia, Wang Fei, Zhang Lihua, et al. Influence of formulation ingredients and physicochemical environment on formation of liquid crystal in alkyl polyglucoside system[J]. China Surfactant Detergent & Cosmetics, 2016, 46 (2):84-88.
[17]	Li Chunlei. Study and preparation of lamellar liquid crystal type skin care emulsions[D]. Shanghai: East China University of Science and Technology, 2014.
[18]	Zhou Meng, Shu Peng, Feng Bei, et al. Properties of lecithin liquid crystal emulsio[J]. Chinese Journal of Applied Chemistry, 2018, 35 (10):1227-1233.
[19]	Yu Mingying, Wang Jing, Yang Cheng, et al. Advances in the applications of Pickering emulsion in cosmetics[J]. China Surfactant Detergent & Cosmetics, 2019, 49 (6):398-402.
[20]	Zhang Liaoyuan. Study on interface characteristics and influencing factors of P/O/W multiple emulsion[D]. Shanghai: Shanghai University of Applied Technology, 2020.
[21]	P Negi, M Aggarwal, G Sharma, et al. Niosome-based hydrogel of resveratrol for topical applications: An effective therapy for pain related disorder(s)[J]. Biomedicine & Pharmacotherapy, 2017, 88: 480-487. doi: 10.1016/j.biopha.2017.01.083
[22]	Yang Jiahui, Liang Rong, Yang Cheng. Cosmetic emulsions and new technologies of emulsification(Ⅲ): Stability of multiple emulsions and their application in cosmetics[J]. China Surfactant Detergent & Cosmetics, 2021, 51 (6):477-484, 495.
[23]	Jia Bing, Zhang Wanping, Chen Minghua. Research progress in liquid crystal structure and the application in cosmetics[J]. Detergent & Cosmetics, 2015, 38 (12):21-26.
[24]	Jia Hongjiao, Li Fangfang, Miao Yulian, et al. Application and research progress of rheology in the field of cosmetics[J]. China Surfactant Detergent & Cosmetics, 2014, 44 (8):467-471.
[25]	Zhou Zhaoqing, Li Yanan, Yin Yuxuan, et al. Influence of hydrophilic polymers on sensory and rheological properties of cosmetic emulsions[J]. Chemical World, 2017, 58 (4):228-234.
[26]	Yuan Fagui, Zhang Jinyu. Effects of sodium carboxymethyl cellulose with different degrees of substitution on the properties of toothpaste[J]. Oral Care Industry, 2020, 30 (3):14-17.

Group	Name	Amount/% （mass fraction）
Polyol	glycerol	3.00
Oil	squalane	9.96
	P135	1.00
	EG	0.04
	liquid crystal emulsifier	4.00
Water	ultrapure water	Add to 100.00

Emulsifying temperature	P/O emulsion preparation stage			P/O/LC/W emulsion preparation stage
Emulsifying temperature	Homogenization rate	Homogenization time		Homogenization rate	Homogenization time
75 ℃	8 400 r/min	6 min		6 000 r/min	7 min

Group	Name	Amount/% （mass fraction）
Oil	Squalane	10.00
Water	Tween 80	4.00
	Carbomer U21	0.15
	10% aqueous solution	0.30
	ultrapure water	Add to 100.00

Preparation of P/O/LC/W multiple emulsion

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