Abstract:

Nanotechnology has practical and potential application value in various fields. Recently, the nanoemulsion, a spontaneous emulsification delivery system has attracted increasing attention, which is composed of oil phase, surfactant, cosurfactant and water phase. An Elaeagnus mollis Diels seed oil nanoemulsion was constructed by self-nanoemulsifying method and its characterization and antioxidant activity were evaluated. The appearance, particle size, particle size distribution and pH value of the nanoemulsion were all showed that the nanoemulsion was qualified. The stability determination of nanoemulsion was tested under different conditions respectively, and the change in particle size was not obvious, and no delamination, turbidity and precipitation occurred, which suggested that the nanoemulsion possessed a good stability. DPPH radical scavenging experiment and hydroxyl radical scavenging experiment were conducted to verify the antioxidant activity of the nanoemulsion. The scavenging ability of Elaeagnus mollis Diels seed oil nanoemulsion and Elaeagnus mollis Diels seed oil to DPPH free radical was increased with the concentration increasing, and the scavenging ability of the nanoemulsion was better than that of the oil. At the same time, the scavenging ability of the nanoemulsion to hydroxyl radicals was significantly stronger than that of Elaeagnus mollis Diels seed oil. Nanoemulsion has smaller particle size, larger specific surface area, which is beneficial to the improvement of drug solubility, stability and antioxidant activity. Nanoemulsion is a promising delivery system, which can provide experimental basis for the application of Elaeagnus mollis Diels seed oil.

Key words: Elaeagnus mollis Diels seed oil, nanoemulsion, antioxidant activity