Abstract:

Photoaging or premature aging of skin is caused by a variety of factors, including hormone imbalance and exposure to ultraviolet radiation. Both ultraviolet light and polycyclic aromatic hydrocarbons in haze can cause skin aging and inflammation. Peach resin is a gum substance secreted from the bark of Rosaceae Prunus persica （L.） Batsch or Prunus davidiana （Carr.） Franch, which is beneficial to health. It also has the advantages of being natural and non-toxic, large in yield, and low in price. Peach gum is a kind of polysaccharide, which has the characteristics of swelling in water and slow release. At present, peach gum has been widely used in food and health care, but the basic research is still relatively weak. Peach gum is a natural cosmetic raw material with great potential for development and application. In this study, a Prunus persica （Peach） resin extract （PG） was prepared and its anti-aging effect was detected by several methods. The results suggested that, based on the model of fibroblast cell aging, PG could promote cell proliferation, Collagen Ⅰ expression and inhibit the activity of beta-GAL in a dosage-dependent manner in the mass fraction range of 0.3% to 10%. In the cell damage model induced by UVA and BaP, PG at the mass fraction between 0.1% to 10% could inhibit the expression of inflammatory factors Prostaglandin E₂ and Matrix metallopeptidase 1. The results of clinical study showed that 5% and 10% PG had significantly increased skin tightening effect. In human clinical evaluation, PG at the mass fraction range of 2% to 10% could significantly increase skin moisture content, reduce transepidermal water loss, improve skin firmness, and reduce wrinkles. As a natural material with anti-aging effect, PG can be used in skin anti-wrinkle products.

Key words: Prunus persica （peach） resin extract, moisturizing, anti-aging, anti-wrinkle