党参复方提取物的活性及洗发液制备与质量研究

doi:10.3969/j.issn.1001-1803.2021.05.008

Abstract

Abstract:

A shampoo was prepared in which radix codonopsis extract was the major active ingredient. The content of total flavonoids in radix codonopsis extract was 8.32% as determined by Al（NO₃） ₃ colorimetry. The in vitro antioxidant ability of radix codonopsis extract was studied. The results showed that the abilities to clear DPPH and hydroxyl radicals and the total antioxidant capacity increased with the increase of mass concentration of total flavonoids. The formulation with an amino acid surfactant as the main surfactant was optimized and evaluated according to GB/T 29679–2013 “Hair shampoo, cream shampoo”. The radix codonopsis shampoo was a product with safe ingredients and good antioxidant capacity and stability.

Key words: radix codonopsis composite, Chinese-medicine shampoo, amino acid surfactant, antioxidant

CLC Number:

TQ423

JIA Ying,ZHAO Jing,XIAO You-qin. Study on the activity of radix codonopsis extract and the preparation and quality of a shampoo[J].China Surfactant Detergent & Cosmetics, 2021, 51(5): 421-427.

Figures/Tables 12

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References 9

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项目	质地	外观	易冲洗程度	去油污能力	梳理性	整体蓬松感	耐热性	耐寒性
分值/分	8~10	8~10	8~10	8~10	8~10	8~10	20	20
描述	细腻	清澈明亮	很容易	强	非常顺滑	轻盈蓬松	无分层	无分层
分值/分	5~7	5~7	5~7	5~7	5~7	5~7	0	0
描述	较为细腻	明亮	较为容易	微弱残留	顺滑	较为扁塌	分层	分层
分值/分	<5	<5	<5	<5	<5	<5	分层	分层
描述	粗糙且分散性差	暗淡无光泽	很难	弱	很涩	厚重	分层	分层

	A							RSD/%
	1	2	3	4	5	6	平均值	RSD/%
重复性	0.560	0.566	0.574	0.557	0.569	0.576	0.567	1.33
精密度	0.555	0.554	0.554	0.557	0.554	0.556	0.555	0.23
稳定性	0.566	0.572	0.583	0.591	0.586	0.605	0.584	2.38

	ρ（总黄酮）/（mg·mL^-1）
	0.28	0.37	0.46	0.56	0.65
As	0.338	0.318	0.314	0.297	0.250
	0.337	0.319	0.307	0.297	0.252
	0.336	0.318	0.311	0.299	0.251
平均值	0.337	0.318	0.311	0.298	0.251
Ac	0.471
DPPH自由基清除率/%	28.45	32.48	33.97	36.73	46.71

	ρ（总黄酮）/（mg·mL^-1）
	0.37	0.42	0.46	0.51	0.56
Bs	0.246	0.249	0.256	0.309	0.381
	0.246	0.249	0.255	0.309	0.381
	0.246	0.248	0.256	0.309	0.382
平均值	0.246	0.248	0.256	0.309	0.381
Bb	0.456
Bc	0.170
羟自由基清除率/%	26.57	27.13	29.95	48.60	73.89

	ρ（总黄酮）/（mg·mL^-1）
	0.37	0.42	0.46	0.51	0.56
第1组	0.927	1.023	1.107	1.229	1.296
第2组	0.939	1.037	1.121	1.233	1.32
第3组	0.938	1.037	1.122	1.235	1.322
平均值	0.935	1.032	1.117	1.232	1.313
FRAP值	1.597	1.765	1.910	2.108	2.246

Study on the activity of radix codonopsis extract and the preparation and quality of a shampoo

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	m/g					总分/分
	LS	ALES	CAB	APG	MEA	总分/分
配方1	7	7	2.5	1	2.5	75.10±5.36
配方2	10	5	1.5	1	2.5	76.60±2.50
配方3	12	4	0.5	1	2.5	80.00±3.71
配方4	12	3	1.5	1	2.5	84.70±2.71
配方5	10	2	4.5	1	2.5	75.80±3.77

	m/g					总分/分
	LS	ALES	CAB	APG	MEA	总分/分
配方6	4.73	1.18	0.59	1	2.5	67.20±4.24
配方7	8.63	2.16	0.71	1	2.5	76.80±2.74
配方4	12	3	1.5	1	2.5	84.70±2.71
配方8	15.64	3.91	1.95	1	2.5	76.70±2.50
配方9	19.27	4.82	2.41	1	2.5	74.90±2.08

	m/g		总分/分
	瓜儿胶	季铵盐-10	总分/分
配方10	0	0.9	74.00±2.71
配方11	0.9	0	31.80±2.10
配方4	0.45	0.45	84.70±2.71
配方12	0.6	0.3	78.30±3.47
配方13	0.3	0.6	87.60±2.37

w（提取物）/%	外观	气味	pH	稳定性	黏度/（mPa·s）
0	澄清透明粘液	无异味	6.83	稳定	283
0.5	浅棕色半透明粘液	中药味	6.72	稳定	208
1.0	棕色半透明粘液	中药味	6.64	稳定	334
1.5	深棕色半透明粘液	中药味	6.49	稳定	343
2.0	深棕色半透明粘液	中药味	6.36	稳定	390

相	试剂	种类	w/%	m/g
A相	LS-30	表面活性剂	20.00	12.0
	CAB-35	表面活性剂		1.5
	APG1214	表面活性剂		1.0
	ALES	表面活性剂		3.0
	MEA	表面活性剂		2.5
B相	党参复方提取物（1 g相当于生药4 g）	活性物	80.00	1.0
	瓜儿胶	阳离子调理剂		0.25
	季铵盐-10	阳离子调理剂		0.5
	甘油	增溶剂		5.0
	EDTA-2Na	螯合剂		0.1
	去离子水	去离子水		余量
	NaCl	增稠剂		3.0
C相	防腐剂	防腐剂	/	适量

组别	空烧杯干燥恒重质量/g	烘干前总质量/g	烘干后总质量/g	X₁/%	总固体平均含量/%
第1组	38. 359 8	40. 457 6	38. 746 0	18.42	16.02
第2组	46. 816 5	48. 828 2	47. 115 1	14.84
第3组	47. 869 0	49. 881 6	48. 167 1	14.81

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	m/g		总分/分
	瓜儿胶	季铵盐-10	总分/分
配方13	0.3	0.6	87.60±2.37
配方14	0.2	0.4	80.00±2.31
配方15	0.25	0.5	89.70±2.16
配方16	0.35	0.7	78.00±4.22
配方17	0.4	0.8	77.80±4.44