疏水改性透明质酸的制备及性能

doi:10.3969/j.issn.1001-1803.2020.11.007

Abstract

Abstract:

Cholesterol （CHO） was grafted onto the molecular structure of hyaluronic acid （HA） through a chemical reaction to obtain a modified product HACHO. ¹H NMR and FT-IR were used to characterize the structure of the modified product. Transmission electron microscope （TEM）, fluorescence spectrum and rheometer were used to study the critical aggregation concentration, self-assembly behavior and rheological behavior of HACHO in water. The cell viability of the modified product HACHO was evaluated by the MTT assay. On this basis, HACHO was used to prepare bi-gel emulsion, and the stability of the emulsion was investigated. The results showed that, HACHO had interfacial activity and good biocompatibility, and could form a network structure in aqueous phase to stabilize the bi-gel emulsion. Therefore, HACHO showed a broad application prospect in the field of cosmetics.

Key words: hyaluronic acid, cholesterol, hydrophobic modification, rheological behavior, bi-gel emulsion

CLC Number:

TQ658

SHI Meng-lin,LIU Li-jia,SHANG Ya-zhuo,LIU Hong-lai. Preparation and properties of hydrophobically modified hyaluronic acid[J].China Surfactant Detergent & Cosmetics, 2020, 50(11): 776-782.

Figures/Tables 7

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References 21

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Preparation and properties of hydrophobically modified hyaluronic acid

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